Methaqualone

DB04833ApprovedIllicitWithdrawnSmall molecule

Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s... Its use peaked in the early 1970s as a hypnotic, sedative, and muscle relaxant commonly used for insomnia.

Mechanism: Pharmacologically active on GABA(A) Receptor
Curator reviewed
Primary indication: For the treatment of insomnia, and as a sedative and muscle relaxant.Curator reviewed
Formula / weight: C₁₆H₁₄N₂O · 250.2952 g/mol (avg)
Code names: CI-705 · CN 38703 · R-148

Resolves to

Compound

UNII7ZKH8MQW6TCAS72-44-6ChEMBLCHEMBL282052ChEBI6821PubChem6292KEGGD00557

Clinical / RWD

RxNorm6823ATCN05CM01ATCN05CX02

Structure

InChIKeyJEYCTXHKTXCGPB-UHFFFAOYSA-NSMILESCC1=CC=CC=C1N1C(C)=NC2=CC=CC=C2C1=O

What you can answer from here — as of July 19, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

762Drug interactionsStructured to mechanism, not free text

2ATC codesIncluding every combination product, plus 13 drug categories

2+ReferencesStructured and connected to the statements they support

Which companies are running trials of Methaqualone, in which indications and phases, and which of those programs are still active?

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