Isatoribine

DB04860ExperimentalSmall molecule

Isatoribine is a selective agonist of TLR7.

Mechanism: Isatoribine is believed to act by a mechanism of action involving interaction with Toll-like receptor 7 (TLR7) and stimulation of the patient's own immune system, but the precise mechanism by which isatoribine reduced viral load is unknown (possible mechanisms include an antiviral effect, modulation of innate immunity, or enhancement of cellular responses).
Curator reviewed
Primary indication: For the treatment of Hepatitis C.Curator reviewed
Formula / weight: C₁₀H₁₂N₄O₆S · 316.29 g/mol (avg)
Code names: ANA-245 · ICN-10146 · NARI-10146

Resolves to

Compound

Structure

InChIKeyTZYVRXZQAWPIAB-FCLHUMLKSA-NSMILESNC1=NC(=O)C2=C(N1)N([C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C(=O)S2

Targets

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Isatoribine, and which of those have an active Phase 3 trial?

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