This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Hemoglobin is an iron-containing protein found in all red blood cells (RBCs) for proper binding of oxygen and transport throughout the body, included in blood transfusions in severe hemorrhage.

Generic Name
Hemoglobin
DrugBank Accession Number
DB04945
Background

The respiratory protein of the red blood cells. It consists primarily of globin and heme.

Type
Biotech
Groups
Approved, Experimental, Investigational
Biologic Classification
Protein Based Therapies
Blood factors
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Deoxyhemoglobin
  • Haemoglobin
  • Human hemoglobin

Pharmacology

Indication

Investigated for use/treatment in blood (blood forming organ disorders, unspecified) and hemorrhage.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

A heme group is made up of iron (Fe) ion (charged atom) located in a heterocyclic ring, which is also called a porphyrin ring. The site of oxygen binding, the iron ion, binds with the nitrogens located in the center of the porphyrin ring. The iron ion binds with high affinity to the globular protein through the imidazole ring of the F8 residue on histidine which is found below the porphyrin ring. A sixth position can bind reversibly to oxygen, completing the formation of the octahedral group. One oxygen atom binds Fe and the other is found to protrude at an angle. When oxygen is not bound to Fe, a water molecule (weakly bound) fills the site, producing a distorted shape, often described as an octahedron.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

This means that the oxygen binding curve for fetal hemoglobin is left-shifted (i.e., a higher percentage of hemoglobin has oxygen bound to it at lower oxygen tension), in comparison to that of adult hemoglobin

Metabolism

There is a group of genetic disorders, known as the porphyrias that are characterized by errors in metabolic pathways of heme synthesis

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Deschiens SiropLiquid8.3 g / 100 mLOralRodeca Inc., Division Of Technilab Inc.1951-12-311999-09-17Canada flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
VSU9IB86SP
CAS number
9008-02-0

References

General References
Not Available
PubChem Compound
195433
PubChem Substance
772701
ChemSpider
169458
RxNav
1860418
ChEBI
35143
Wikipedia
Hemoglobin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentShock / Systemic Inflammatory Response Syndrome (SIRS)1
2CompletedTreatmentAcute Coronary Syndrome (ACS) / Coronary Occlusions1
2CompletedTreatmentAngina Pectoris / Myocardial Infarction / Unstable Angina Pectoris1
2CompletedTreatmentLactic Acidosis / Shock, Hemorrhagic / Traumatic Shock1
2Unknown StatusTreatmentCoronary Artery Disease (CAD)1
2Unknown StatusTreatmentWounds and Injuries1
2WithdrawnTreatmentLactic Acidosis / Shock, Hemorrhagic / Traumas1
Not AvailableCompletedNot AvailableAnemia Deficiency / Solid Tumors, Adult1
Not AvailableCompletedNot AvailableElective Hepatic Resection1
Not AvailableCompletedNot AvailablePatients' Assessment1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidOral8.3 g / 100 mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Drug created at October 21, 2007 22:23 / Updated at June 12, 2020 16:52