Tetomilast

DB05298InvestigationalSmall molecule

Tetomilast has been used in trials studying the treatment of Crohn Disease, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease.

Chemical structure of Tetomilast
Mechanism
Curator reviewed
Primary indication
Investigated for use/treatment in ulcerative colitis.Curator reviewed
Formula / weight
C19H18N2O4S · 370.422 g/mol (avg)
Code names
OPC-6535

Resolves to

Compound
UNIIS6RXB5KF56CAS145739-56-6ChEMBLCHEMBL332750PubChem3025803
Structure
InChIKeyXDBHURGONHZNJF-UHFFFAOYSA-NSMILESCCOC1=C(OCC)C=C(C=C1)C1=NC(=CS1)C1=NC(=CC=C1)C(O)=O
Targets
Q08499PDE4D

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
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6Clinical trialsPhase, status and sponsor resolved per trial
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4+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Tetomilast, and which of those have an active Phase 3 trial?

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