SO-101(Silenor) is a low-dose oral tablet formulation of doxepin hydrochloride that is patent protected for its use in insomnia. Doxepin has been prescribed for more than 40 years for the... Doxepin has been prescribed for more than 40 years for the treatment of depression and anxiety at dosages typically ranging from 75 mg to 300 mg per day.
- Mechanism
- Curator reviewed
The mechanism of action for the sleep-promoting effects of is not definitively known, it differs from the currently available sleep-promoting agents in that the effects are mediated through the histaminergic system. The active ingredient in SO-101, doxepin HCl, is known to be a highly potent histamine antagonist. Histamine blocking has been demonstrated to reduce wakefulness and is thought to promote the initiation and maintenance of sleep.
- Primary indication
- Investigated for use/treatment in insomnia.Curator reviewed
- Code names
- SO-101
Resolves to
What you can answer from here — as of April 02, 2025
Which drugs share a target with SO-101, and which of those have an active Phase 3 trial?
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