99mTc-Ciprofloxacin is a new formulation of ciprofloxacin (INFECTON), being investigated as a radioimaging agent for the potential diagnosis of infection, including fever of unknown origin, osteomyelitis, wound infection, abdominal abscess,... INFECTON combines the widely used antibiotic, ciprofloxacin, with Technetium ((99m)Tc), the most commonly used radioisotope in nuclear medical imaging There is currently controversy around the drug's ability to discriminate between sterile inflammation and bacterial versus...
- Mechanism
- Curator reviewed
Ciprofloxacin is a fluoroquinolone antibiotic. The mechanism of action of these fluoroquinolones is not fully understood, but it has been postulated that the interaction of ciprofloxacin with bacterial DNA gyrase (a type II topoisomerase) prevents DNA uncoiling and subsequent DNA synthesis within bacteria. Ciprofloxacin demonstrates a significant antibiotic effect for both gram-negative and gram-positive bacteria in either stationary or growth phases of bacterial replication. However, the addition of the 99mTc atom likely affects the interaction of the ciprofloxacin molecule with the enzyme.
- Primary indication
- Investigated for use/treatment in infectious and parasitic disease (unspecified).Curator reviewed
- Also known as
- 99mTc-ciprofloxacin · Infecton · Technetium (99mTc) ciprofloxacin · Technetium Tc 99m ciprofloxacin
Resolves to
What you can answer from here — as of April 02, 2025
Which drugs share a target with Technetium Tc-99m ciprofloxacin, and which of those have an active Phase 3 trial?
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