Varespladib methyl

Identification

Name
Varespladib methyl
Accession Number
DB05737
Description

Varespladib methyl has been investigated for the treatment of Acute Coronary Syndrome. Studies showed that Varespladib methyl treatment resulted in significant positive changes on lipoproteins and inflammation.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 394.427
Monoisotopic: 394.152871816
Chemical Formula
C22H22N2O5
Synonyms
  • Varespladib methyl ester
External IDs
  • A-002
  • LY-333013
  • LY333013
  • S-3013

Pharmacology

Indication

Investigated for use/treatment in atherosclerosis and coronary artery disease.

Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action

A–002 is an orally administered‚ potent inhibitor of secretory phospholipase spla2(spla2)‚ including groups IIA‚ V‚ and X. Atherosclerosis is a disease of the arteries that results from inflammation and the build-up of plaque under the lining of the blood vessel. This build-up can cause vascular swelling and eventual rupture. spla2 levels have been shown to be elevated in patients with both stable and unstable coronary artery disease. Higher levels of the enzyme have been shown to predict an increased risk for future cardiovascular events such as heart attacks and stroke.

TargetActionsOrganism
UPhospholipase A2, membrane associatedNot AvailableHumans
UGroup 10 secretory phospholipase A2Not AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

International/Other Brands
Varespladib

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenoxyacetic acid derivatives. These are compounds containing an anisole where the methane group is linked to an acetic acid or a derivative.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Phenoxyacetic acid derivatives
Direct Parent
Phenoxyacetic acid derivatives
Alternative Parents
N-alkylindoles / Indoles / Phenol ethers / Aryl ketones / Alkyl aryl ethers / Substituted pyrroles / Vinylogous amides / Methyl esters / Heteroaromatic compounds / Primary carboxylic acid amides
show 5 more
Substituents
Alkyl aryl ether / Aromatic heteropolycyclic compound / Aryl ketone / Azacycle / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Carboxylic acid ester / Ether / Heteroaromatic compound
show 19 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Chemical Identifiers

UNII
0NB98NBX3D
CAS number
172733-08-3
InChI Key
VJYDOJXJUCJUHL-UHFFFAOYSA-N
InChI
InChI=1S/C22H22N2O5/c1-3-15-20(21(26)22(23)27)19-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(19)29-13-18(25)28-2/h4-11H,3,12-13H2,1-2H3,(H2,23,27)
IUPAC Name
methyl 2-{[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxy}acetate
SMILES
CCC1=C(C(=O)C(N)=O)C2=C(OCC(=O)OC)C=CC=C2N1CC1=CC=CC=C1

References

General References
Not Available
PubChem Compound
9886917
PubChem Substance
347827740
ChemSpider
8062590
ChEMBL
CHEMBL2105659
ZINC
ZINC000001550156
Wikipedia
Varespladib_methyl

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentAcute Coronary Syndromes (ACS)1
2CompletedPreventionCoronary Artery Disease (CAD)3
2CompletedTreatmentAcute Coronary Syndromes (ACS)1
2TerminatedPreventionSickle Cell Disease (SCD) / Vaso-occlusive Crisis1
1CompletedBasic ScienceHealthy Volunteers1
1TerminatedBasic ScienceImpaired kidney function1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00343 mg/mLALOGPS
logP3.34ALOGPS
logP2.92ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)13.81ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area100.62 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity107.66 m3·mol-1ChemAxon
Polarizability41.16 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Phospholipid binding
Specific Function
Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-ph...
Gene Name
PLA2G2A
Uniprot ID
P14555
Uniprot Name
Phospholipase A2, membrane associated
Molecular Weight
16082.525 Da
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Phospholipase activity
Specific Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosph...
Gene Name
PLA2G10
Uniprot ID
O15496
Uniprot Name
Group 10 secretory phospholipase A2
Molecular Weight
18153.04 Da

Drug created on November 18, 2007 11:27 / Updated on June 12, 2020 10:52

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