DB05803InvestigationalSmall molecule
ISIS 14803 is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits...
- Mechanism
- Curator reviewed
ISIS 14803 blocks the synthesis of disease-causing proteins by preventing translation of viral RNA. In the case of hepatits C virus (HCV), an antisense oligodeoxynucleotide directed against a specific HCV sequence effectively inhibits viral gene expression.
- Primary indication
- Investigated for use/treatment in hepatitis (viral, C).Curator reviewed
- Code names
- ISIS 14803
What you can answer from here — as of April 02, 2025
Which companies are running trials of ISIS 14803, in which indications and phases, and which of those programs are still active?
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