HGTV43 is an anti-sense treatment designed to produce T cells that are genetically resistant to HIV infection. HGTV43 is one of a number of so-called 'gene transfer vectors' developed by...
- Mechanism
- Curator reviewed
HGTV43 works by 'turning off' the genes which HIV needs to grow and reproduce in human cells. Engineered genes are inserted directly into cells to regulate the function of the genes essential for HIV replication. These genetically modified CD4 cells are then transferred back to the individual. The theory is that these individuals will thus have a pool of fully functioning CD4 cells immune to HIV infection.
- Primary indication
- Investigated for use/treatment in HIV infection.Curator reviewed
- Code names
- HGTV-43
Which companies are running trials of HGTV-43, in which indications and phases, and which of those programs are still active?
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