NS-3728

DB05835ExperimentalSmall molecule

NS3728 is an orally active chloride channel blocker for the treatment of cancer.

Mechanism: NS-3728 (Endovion) blocks a certain subtype of chloride ion channels important for cell division, cell migration and the formation of new blood vessels (angiogenesis).
Curator reviewed
Primary indication: Investigated for use/treatment in anemia (sickle cell) and cancer/tumors (unspecified).Curator reviewed
Formula / weight: C₁₆H₉BrF₆N₆O · 495.183 g/mol (avg)
Also known as: Endovion
Code names: NS-3728

Resolves to

Compound

Structure

InChIKeyOQRAKHDEGGGWQO-UHFFFAOYSA-NSMILESFC(F)(F)C1=CC(=CC(NC(=O)NC2=C(C=CC(Br)=C2)C2=NNN=N2)=C1)C(F)(F)F

Targets

What you can answer from here — as of July 03, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with NS-3728, and which of those have an active Phase 3 trial?

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