UC-781

DB05871InvestigationalSmall molecule

UC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a topical microbicide targeted against the AIDS virus.

Mechanism: UC-781 is an HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) that has shown in vitro to be very active specifically against HIV-1. UC-781 exhibits synergy with the NRTI zidovudine in vitro. The combination of UC-781 and another candidate microbicide, cellulose acetate 1,2-benzenedicarboxylate, resulted in effective synergy for inhibition of HIV-1 in vitro and in peripheral blood mononuclear cells
Curator reviewed
Primary indication: Investigated for use/treatment in HIV infection.Curator reviewed
Formula / weight: C₁₇H₁₈ClNO₂S · 335.848 g/mol (avg)
Code names: NSC-675186 · UC-781

Resolves to

Compound

Structure

InChIKeyYZHIXLCGPOTQNB-UHFFFAOYSA-NSMILESCC(C)=CCOC1=C(Cl)C=CC(NC(=S)C2=C(C)OC=C2)=C1

Targets

What you can answer from here — as of August 26, 2024

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

14Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with UC-781, and which of those have an active Phase 3 trial?

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