NAV

Phleum pratense pollen

Identification

Summary

Phleum pratense pollen is an extract from Phleum pratense pollen used in allergy testing.

Brand Names
Grastek, Oralair 100, Oralair 300, Oralair Children and Adolescents Sample Kit
Generic Name
Phleum pratense pollen
DrugBank Accession Number
DB10394
Background

Phleum pratense pollen allergenic extract is used in allergenic testing.

Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Allergenics
Allergen Extract
Synonyms
  • Allergenic extract, grass, timothy
  • Allergenic extract, timothy grass
  • Allergenic extract,timothy grass pollen
  • Common timothy pollen
  • Grass pollen extract
  • Phleum nodosum pollen
  • Phleum pratense
  • Phleum pratense pollen extract
  • Standardized timothy grass pollen
  • Timothy grass (phleum pretense) pollen standardized
  • Timothy grass pollen
  • Timothy grass pollen extract
  • Timothy grass pollen extracts
  • Timothy pollen
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Pharmacology

Indication

Phleum pratense pollen is an allergen extract included in an allergenic testing product called ORALAIR. It is indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollen38 specific IgE antibodies for any of the five grass species contained in this product. ORALAIR is approved for use in persons 5 through 65 years of age.3

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination for diagnostic processAllergic rhinitis due to pollen••••••••••••
Used in combination for diagnostic processAllergic rhinitis due to pollen••••••••••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AcebutololThe risk of a hypersensitivity reaction to Phleum pratense pollen is increased when it is combined with Acebutolol.
AtenololThe risk of a hypersensitivity reaction to Phleum pratense pollen is increased when it is combined with Atenolol.
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Phleum pratense pollen.
BetaxololThe risk of a hypersensitivity reaction to Phleum pratense pollen is increased when it is combined with Betaxolol.
BisoprololThe risk of a hypersensitivity reaction to Phleum pratense pollen is increased when it is combined with Bisoprolol.
Food Interactions
Not Available

Products

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Active Moieties
NameKindUNIICASInChI Key
Phleum pratense topunknownS7PW24BX20Not AvailableNot applicable
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Allergen Pack Timothy GrassSolution10000 [BAU]/1mLIntradermal; SubcutaneousAlvix Laboratories2015-07-092018-03-08US flag
Allergenic Extract - Standardized Grass Pollen - TimothyLiquid10000 unit / mLIntradermal; SubcutaneousGreer Laboratories2015-03-10Not applicableCanada flag
Allergenic Extract - Standardized Grass Pollen - TimothyLiquid100000 unit / mLIntradermal; SubcutaneousGreer Laboratories2000-10-30Not applicableCanada flag
Allergenic Extract - Standardized Timothy Grass PollenLiquid100000 unit / mLIntradermal; Percutaneous; SubcutaneousAlk Abello, Inc.2009-07-30Not applicableCanada flag
Center-AL - Phleum Pratense PollenInjection, suspension10000 [PNU]/1mLSubcutaneousALK-Abello, Inc.1975-01-15Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
5 Grass MixPhleum pratense pollen (100 [PNU]/1mL) + Agrostis gigantea pollen (100 [PNU]/1mL) + Anthoxanthum odoratum pollen (100 [PNU]/1mL) + Dactylis glomerata pollen (100 [PNU]/1mL) + Poa pratensis pollen (100 [PNU]/1mL)Injection, solutionSubcutaneousALK-Abello, Inc.1975-01-152023-05-24US flag
5 Grass MixPhleum pratense pollen (1000 [PNU]/1mL) + Agrostis gigantea pollen (1000 [PNU]/1mL) + Anthoxanthum odoratum pollen (1000 [PNU]/1mL) + Dactylis glomerata pollen (1000 [PNU]/1mL) + Poa pratensis pollen (1000 [PNU]/1mL)Injection, solutionSubcutaneousALK-Abello, Inc.1975-01-152023-05-25US flag
5 Grass MixPhleum pratense pollen (20000 [PNU]/1mL) + Agrostis gigantea pollen (20000 [PNU]/1mL) + Anthoxanthum odoratum (20000 [PNU]/1mL) + Dactylis glomerata pollen (20000 [PNU]/1mL) + Poa pratensis pollen (20000 [PNU]/1mL)Injection, solutionSubcutaneousALK-Abello, Inc.1975-01-152023-05-25US flag
5 Grass MixPhleum pratense pollen (10000 [PNU]/1mL) + Agrostis gigantea pollen (10000 [PNU]/1mL) + Anthoxanthum odoratum pollen (10000 [PNU]/1mL) + Dactylis glomerata pollen (10000 [PNU]/1mL) + Poa pratensis pollen (10000 [PNU]/1mL)Injection, solutionSubcutaneousALK-Abello, Inc.1975-01-152023-05-25US flag
5 Grass MixPhleum pratense pollen (10000 [PNU]/1mL) + Agrostis gigantea pollen (10000 [PNU]/1mL) + Anthoxanthum odoratum (10000 [PNU]/1mL) + Dactylis glomerata pollen (10000 [PNU]/1mL) + Poa pratensis pollen (10000 [PNU]/1mL)Injection, solutionSubcutaneousALK-Abello, Inc.1975-01-15Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Allergen Pack Timothy GrassPhleum pratense pollen (10000 [BAU]/1mL)SolutionIntradermal; SubcutaneousAlvix Laboratories2015-07-092018-03-08US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
0P46LFE4VC
CAS number
Not Available

References

General References
  1. TePas EC, Hoyte EG, McIntire JJ, Umetsu DT: Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals. Ann Allergy Asthma Immunol. 2004 Jan;92(1):25-31. [Article]
  2. Patel P, Salapatek AM: Pollinex Quattro: a novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev Vaccines. 2006 Oct;5(5):617-29. [Article]
  3. FDA Approved Drug Products: ORALAIR 6 (Sweet Vernal, Orchard, Perennial Rye, Timothy, and Kentucky Blue Grass Mixed Pollens Allergen Extract) Tablet for Sublingual Use [Link]
PubChem Substance
347910569
RxNav
851994

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentAllergic Reaction1
4CompletedTreatmentRhinoconjunctivitis, Allergic1
4CompletedTreatmentSeasonal Allergic Rhinitis1
3CompletedTreatmentAllergic Reaction1
3CompletedTreatmentSeasonal Allergic Rhinitis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionSubcutaneous
SolutionIntradermal; Subcutaneous10000 [BAU]/1mL
LiquidIntradermal; Percutaneous; Subcutaneous
LiquidIntradermal; Subcutaneous10000 unit / mL
LiquidIntradermal; Subcutaneous100000 unit / mL
LiquidIntradermal; Percutaneous; Subcutaneous100000 unit / mL
LiquidSubcutaneous
SolutionIntradermal; Subcutaneous
Injection, suspensionSubcutaneous10000 [PNU]/1mL
Injection, suspensionSubcutaneous20000 [PNU]/1mL
Injection, solutionPercutaneous
TabletSublingual2800 [BAU]/1
Tablet, orally disintegratingSublingual2800 unit
TabletOral75000 SQ-T
PowderOral75000 SQ-T
TabletOral
KitSublingual
Kit; tablet, orally disintegratingSublingual
TabletSublingual100 [IR]
TabletSublingual300 [IR]
Tablet, orally disintegratingSublingual
TabletSublingual
LiquidIntradermal100 unit / mL
LiquidIntradermal1000 unit / mL
SolutionPercutaneous; Subcutaneous10000 unit / mL
SolutionPercutaneous; Subcutaneous100000 unit / mL
Injection, solutionIntradermal
Injection, solutionPercutaneous; Subcutaneous
Injection, solutionIntradermal100 [BAU]/1mL
Injection, solutionIntradermal1000 [BAU]/1mL
Injection, solutionPercutaneous; Subcutaneous10000 [BAU]/1mL
InjectionCutaneous; Intradermal; Subcutaneous100000 [BAU]/1mL
Injection, solutionIntradermal; Subcutaneous10000 [BAU]/1mL
Injection, solutionIntradermal; Subcutaneous100000 [BAU]/1mL
Injection, solutionPercutaneous; Subcutaneous100000 [BAU]/1mL
SolutionIntradermal; Percutaneous; Subcutaneous10000 [BAU]/1mL
SolutionIntradermal; Percutaneous; Subcutaneous100000 [BAU]/1mL
SolutionIntradermal; Percutaneous; Subcutaneous
Injection, solutionSubcutaneous10000 [BAU]/1mL
Injection, solutionSubcutaneous100000 [BAU]/1mL
SolutionPercutaneous10000 [BAU]/1mL
SolutionPercutaneous100000 [BAU]/1mL
Injection, solutionIntradermal; Subcutaneous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at December 01, 2015 20:03 / Updated at April 17, 2024 06:33