MD-0727

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Identification

Generic Name: MD-0727
DrugBank Accession Number: DB05948
Background: MD-0727 is a novel, potent cholesterol absorption inhibitor (CAI) under investigation for the treatment of hypercholesterolemia (high cholesterol.
Type: Small Molecule
Groups: Investigational
Synonyms: Not Available

Pharmacology

Indication: Investigated for use/treatment in hyperlipidemia.

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Pharmacodynamics: Not Available
Mechanism of action: MD-0727 works in a unique manner compared with traditional cholesterol medications known as statins. It reduces the amount of cholesterol absorbed from the digestive tract, whereas statins inhibit the production of cholesterol in the liver.
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

Chemical Identifiers

UNII: Not Available
CAS number: Not Available
InChI Key: Not Available
InChI: Not Available
IUPAC Name: Not Available
SMILES: Not Available

References

General References: Not Available
External Links: Not Available

Clinical Trials

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Phase	Status	Purpose	Conditions	Count	Start Date	Why Stopped	100+ additional columns
Unlock 175K+ rows when you subscribe.View sample data
2	Completed	Treatment	High Cholesterol	1	somestatus	stop reason	just information to hide

Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage Forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State: Solid
Experimental Properties: Not Available
Predicted Properties: Not Available
Predicted ADMET Features: Not Available

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available
Chromatographic Properties: Collision Cross Sections (CCS)
Not Available

Carriers

Details1. Apolipoprotein A-I

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Specific Function: amyloid-beta binding
Gene Name: APOA1
Uniprot ID: P02647
Uniprot Name: Apolipoprotein A-I
Molecular Weight: 30777.58 Da

Drug created at November 18, 2007 18:29 / Updated at June 12, 2020 16:52