ASI402
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- ASI402
- DrugBank Accession Number
- DB06373
- Background
ASI402 is a monoclonal antibody that targets an aberrantly glycosylated antigen Mucin 1. It is being investigated in cancers.
- Type
- Biotech
- Groups
- Investigational
- Biologic Classification
- Protein Based Therapies
Monoclonal antibody (mAb) - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Epitumomab
- IMMUNOGLOBULIN G1, ANTI-(HUMAN EPISIALIN) (HUMAN-MOUSE MONOCLONAL HMFG-1 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL HMFG-1, DIMER
- IMMUNOGLOBULIN G1, ANTI-(HUMAN EPISIALIN) (MOUSE MONOCLONAL HMFG-1 .GAMMA.1-CHAIN), DISULFIDE WITH MOUSE MONOCLONAL HMFG-1, DIMER
- SONTUZUMAB
- External IDs
- AS-1402
- BTH-1704
- BTH1704
- HUHMFG-1
- R-1550
- R1550
Pharmacology
- Indication
Investigated for use/treatment in breast cancer.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
ASI402 is an antibody (humanised HMFG1) that targets and binds to a protein called MUC1. This protein is exposed only on the surface of cancer cells, so the antibody binds specifically to tumours. Evidence suggests that the antibody then recruits components of the immune system called 'natural killer cells' to attack the cancer cells. ASI402 has broad potential because the MUC1 protein that it targets is made by many different types of cancer.
Target Actions Organism UMucin-1 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 3VD89OE565
- CAS number
- 372075-37-1
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data2 Terminated Treatment Breast Carcinoma 1 somestatus stop reason just information to hide 1 Completed Treatment Breast Cancer 1 somestatus stop reason just information to hide 1 Terminated Treatment Pancreatic Cancer 1 somestatus stop reason just information to hide 1, 2 Unknown Status Treatment Breast Cancer 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack
- Specific Function
- P53 binding
- Gene Name
- MUC1
- Uniprot ID
- P15941
- Uniprot Name
- Mucin-1
- Molecular Weight
- 122100.89 Da
Drug created at March 19, 2008 16:27 / Updated at August 01, 2024 14:13