Aprinocarsen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Aprinocarsen
DrugBank Accession Number
DB06451
Background

Aprinocarsen is a specific antisense oligonucleotide inhibitor of protein kinase C-alpha.

Type
Biotech
Groups
Investigational
Biologic Classification
Gene Therapies
Antisense oligonucleotides
Synonyms
  • Aprinocarsen
  • PKC-alpha
External IDs
  • ISIS 3521
  • ISIS-3521
  • LY 900003
  • LY-900003
  • LY900003

Pharmacology

Indication

Investigated for use/treatment in lung cancer.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UProtein kinase C alpha typeNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Aprinocarsen sodium1U68ZWZ6OX331257-53-5Not applicable
International/Other Brands
Affintak

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
FMT95051CQ
CAS number
151879-73-1

References

General References
Not Available
RxNav
2634355

Clinical Trials

Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
3CompletedTreatmentLung Cancer1somestatusstop reasonjust information to hide
3CompletedTreatmentNon-Small Cell Lung Carcinoma1somestatusstop reasonjust information to hide
2CompletedTreatmentBreast Cancer1somestatusstop reasonjust information to hide
2CompletedTreatmentLung Cancer / Melanoma1somestatusstop reasonjust information to hide
2CompletedTreatmentLung Neoplasm / Non-Small Cell Lung Carcinoma1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differenti...
Gene Name
PRKCA
Uniprot ID
P17252
Uniprot Name
Protein kinase C alpha type
Molecular Weight
76749.445 Da
References
  1. Lahn M, Sundell K, Kohler G: The role of protein kinase C-alpha in hematologic malignancies. Acta Haematol. 2006;115(1-2):1-8. [Article]
  2. Vansteenkiste J, Canon JL, Riska H, Pirker R, Peterson P, John W, Mali P, Lahn M: Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer. Invest New Drugs. 2005 Jun;23(3):263-9. [Article]

Drug created at March 19, 2008 16:33 / Updated at September 05, 2022 12:50