MLN576

DB06517ExperimentalSmall molecule

XR11576 (MLN576) is a novel monophenazine with a mechanism of action that includes interaction with both topoisomerase (Topo) I and II.

Mechanism: Pharmacologically active on DNA topoisomerase 2-alpha, DNA topoisomerase 1, and DNA topoisomerase 2
Curator reviewed
Primary indication: Investigated for use/treatment in solid tumors.Curator reviewed
Formula / weight: C₂₃H₂₄N₄O₂ · 388.471 g/mol (avg)
Code names: MLN-576 · XR-11576

Resolves to

Compound

Structure

InChIKeyACAXGYADTLFREX-CQSZACIVSA-NSMILESCOC1=C2C=CC3=NC4=CC=CC(C(=O)N[C@H](C)CN(C)C)=C4N=C3C2=CC=C1

Targets

What you can answer from here — as of July 03, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with MLN576, and which of those have an active Phase 3 trial?

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