Identification

Name
Manganese
Accession Number
DB06757
Description

Manganese is a transition metal with a molar mass of 54.94g/mol. Manganese is considered critical for human health, and plays important roles in development, metabolism, and the antioxidant system. That said, excessive manganese intake is associated with manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms.

Type
Small Molecule
Groups
Approved, Nutraceutical
Structure
Thumb
Weight
Average: 54.938
Monoisotopic: 54.938049636
Chemical Formula
Mn
Synonyms
Not Available

Pharmacology

Indication

Indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialNot AvailableHumans
UIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialNot AvailableHumans
UTGF-beta-activated kinase 1 and MAP3K7-binding protein 1Not AvailableHumans
UArginase-1Not AvailableHumans
USerotransferrinNot AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Product Ingredients
IngredientUNIICASInChI Key
Manganese chloride6YB4901Y907773-01-5GLFNIEUTAYBVOC-UHFFFAOYSA-L
Manganese chloride tetrahydrateQQE170PANO13446-34-9CNFDGXZLMLFIJV-UHFFFAOYSA-L
Manganese sulfateW00LYS4T2610034-96-5ISPYRSDWRDQNSW-UHFFFAOYSA-L
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ManganeseInjection, solution0.1 mg/1mLIntravenousHospira, Inc.2005-01-31Not applicableUS flag
Manganese SulfateInjection, solution0.1 mg/1mLIntravenousAMERICAN REGENT, INC.1990-09-30Not applicableUS flag
Micro MnSolutionIntravenousSandoz Canada Incorporated1992-12-31Not applicableCanada flag
Micro MnSolutionIntravenousSandoz Canada Incorporated1992-12-312018-08-01Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Bio-plex Tab 0.95mgTabletOralTherapeutic Foods Co.1988-12-312001-07-31Canada flag
Chelated Manganese Tablets - 5mgTabletOralAlbion1996-09-062002-07-12Canada flag
Chelazome Manganese Cap 15mgCapsuleOralTrophic Canada Ltd.1987-12-312008-08-28Canada flag
Hvp Chelated Manganese 30mgTabletOralSwiss Herbal Remedies Ltd.1999-09-162003-09-10Canada flag
ManganeseCapsule30 mgOralSeroyal International Inc.1993-12-312009-07-06Canada flag
Manganese (gluconate) 10 Mg TabletsTabletOralGeneral Nutrition Canada Inc.1997-04-182006-08-03Canada flag
Manganese 30mg - TabTabletOralHealth Wise Nutrition Inc.1997-08-151998-08-25Canada flag
Manganese Caps 10mgCapsuleOralTwin Laboratories Inc.1995-12-311999-11-10Canada flag
Manganese Chelate Tab 15mgTabletOralLes Produits Naturels Suisse Inc.1985-12-311996-09-09Canada flag
Manganese Chelated Tab 50mgTabletOralGahler Enterprises Ltd.1988-12-311999-01-27Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
24 Multivitamins + MineralsManganese (2 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-04-302002-07-31Canada flag
50 Plus Multiple Vitamins & MineralsManganese (5 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)TabletOralGfr Pharma Ltd.2002-10-202004-06-15Canada flag
A.R.T.H. Away FormulaManganese (0.58 mg) + Calcium (24 mg) + Cholecalciferol (45 unit) + Copper (0.232 mg) + Folic acid (0.025 mg) + Pyridoxine hydrochloride (0.5 mg) + Selenium (1.54 mcg) + Zinc (0.63 mg)CapsuleOralAbundance Naturally Ltd1999-02-012006-06-16Canada flag
A/o-26 - CapletManganese (2.5 mg) + Beta carotene (7500 unit) + Calcium (75 mg) + Calcium ascorbate (250 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg)TabletOralEnviro Tech International Canada1996-12-191999-07-26Canada flag
Acti-MN + B1 + C CapletManganese (30.0 mg) + Calcium ascorbate (100 mg) + Thiamine hydrochloride (20 mg)TabletOralActi Form Ltd.1991-12-312005-03-21Canada flag
AddnutrivManganese (55 mcg) + Chromic chloride (10 mcg) + Cupric Chloride (380 mcg) + Ferric chloride (1100 mcg) + Potassium Iodide (130 mcg) + Sodium selenite (79 mcg) + Sodium fluoride (950 mcg) + Sodium molybdate (19 mcg) + Zinc (5000 mcg)SolutionIntravenousFresenius KabiNot applicableNot applicableCanada flag
Adrenergy TabletsManganese (1 mg) + Ascorbic acid (150 mg) + Nicotinamide (80 mg) + Pantothenic acid (60 mg) + Zinc (5 mg)TabletOralMorter HealthsystemNot applicableNot applicableCanada flag
Adult Formula 50+Manganese (2.5 mg) + Ascorbic acid (120 mg) + Beta carotene (3000 unit) + Biotin (30 mcg) + Calcium (220 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Iodine (0.15 mg) + Magnesium (100 mg) + Molybdenum (10 mcg) + Nicotinamide (20 mg) + Calcium pantothenate (20 mg) + Potassium (37.5 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (3.4 mg) + Selenium (10 mcg) + Thiamine hydrochloride (4.5 mg) + Vitamin A palmitate (3000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralWn Pharmaceuticals Ltd.2002-04-252009-09-28Canada flag
Advanced 2000 CapsulesManganese (1 mg) + Choline (15 mg) + Chromium (50 mcg) + Inositol (15 mg) + Pantothenic acid (15 mg) + Pyridoxine hydrochloride (4 mg)CapsuleOralBody Gold, A Division Of Pep Products, Inc.2000-01-012002-08-22Canada flag
Advanced B & T FormulaManganese (3.33 mg) + Ascorbic acid (33.3 mg) + Calcium (200 mg) + Chromium (33.33 mcg) + Copper (0.5 mg) + Cyanocobalamin (6.67 mcg) + Folic acid (0.133 mg) + Iron (1.67 mg) + Magnesium (83.3 mg) + Nicotinamide (6.67 mg) + Calcium pantothenate (5 mg) + Phosphorus (100 mg) + Potassium (16.67 mg) + Pyridoxine hydrochloride (6.67 mg) + Riboflavin (2.67 mg) + Selenium (33.33 mcg) + Silicon (0.333 mg) + Sodium molybdate (16.67 mcg) + Thiamine (2.67 mg) + Vanadium (8.33 mg) + Vitamin D (66.67 unit) + Zinc (5 mg)CapsuleOralNutraceutical CorporationNot applicableNot applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Addamel NManganese chloride tetrahydrate (0.027 mg/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2013-05-072017-03-31US flag
CentratexManganese sulfate (1.3 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralCenturion Labs, LLC2009-06-14Not applicableUS flag
Concept OBManganese sulfate (1.3 mg/1) + Ascorbic acid (210 mg/1) + Biotin (300 ug/1) + Cupric sulfate pentahydrate (800 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous fumarate (130 mg/1) + Folic acid (1 mg/1) + Iron (92.4 mg/1) + Magnesium sulfate (6.9 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine mononitrate (5 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUS flag
Ellis TonicManganese sulfate (0.7 mg/15mL) + Cyanocobalamin (2 ug/15mL) + Dexpanthenol (3 mg/15mL) + Magnesium sulfate (0.7 mg/15mL) + Nicotinamide (7 mg/15mL) + Pyridoxine hydrochloride (0.7 mg/15mL) + Riboflavin (0.6 mg/15mL) + Thiamine hydrochloride (0.5 mg/15mL) + Zinc sulfate, unspecified form (5 mg/15mL)LiquidOralBreckenridge Pharmaceutical, Inc.2001-01-012011-11-01US flag
Manganese SulfateManganese sulfate (0.1 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1990-09-30Not applicableUS flag
Megavite RxManganese (5 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromic chloride hexahydrate (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (27 mg/1) + Folic acid (1 mg/1) + Lemon (50 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine Se-75 (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1)Tablet, film coatedOralBreckenridge Pharmaceutical, Inc.2009-06-012010-03-31US flag
Multi Vitamin and Mineral vitaminManganese (1.2 mg/1) + Manganese (0.76 mg/1) + Ascorbic acid (35 mg/1) + D-alpha-Tocopherol acetate (10 mg/1) + Folic acid (0.1 mg/1) + Nicotinamide (7.5 mg/1) + Calcium pantothenate (1.5 mg/1) + Pyridoxine (0.4 mg/1) + Riboflavin (0.3 mg/1) + Thiamine chloride (0.36 mg/1) + Vitamin A (3.5 mg/1) + Zinc oxide (4.3 mg/1)Tablet, chewableOralSaimdang Cosmetics Co., Ltd2010-08-21Not applicableUS flag
Multi Vitamin and Mineral vitaminManganese (1.2 mg/1) + Manganese (0.76 mg/1) + Ascorbic acid (35 mg/1) + D-alpha-Tocopherol acetate (10 mg/1) + Folic acid (0.1 mg/1) + Nicotinamide (7.5 mg/1) + Calcium pantothenate (1.5 mg/1) + Pyridoxine (0.4 mg/1) + Riboflavin (0.3 mg/1) + Thiamine chloride (0.36 mg/1) + Vitamin A (3.5 mg/1) + Zinc oxide (4.3 mg/1)Tablet, chewableOralSaimdang Cosmetics Co., Ltd2010-08-21Not applicableUS flag
Multitrace -4Manganese sulfate (1.54 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-11-29Not applicableUS flag
Multitrace -4Manganese sulfate (1.54 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-07Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous metal compounds
Class
Homogeneous transition metal compounds
Sub Class
Not Available
Direct Parent
Homogeneous transition metal compounds
Alternative Parents
Not Available
Substituents
Homogeneous transition metal
Molecular Framework
Not Available
External Descriptors
monoatomic dication, divalent metal cation, manganese cation (CHEBI:29035) / a cation (MN+2)

Chemical Identifiers

UNII
H6EP7W5457
CAS number
7439-96-5
InChI Key
WAEMQWOKJMHJLA-UHFFFAOYSA-N
InChI
InChI=1S/Mn/q+2
IUPAC Name
manganese(2+) ion
SMILES
[Mn++]

References

General References
  1. Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. [PubMed:17469137]
Human Metabolome Database
HMDB0001333
KEGG Drug
D04854
KEGG Compound
C19610
PubChem Compound
27854
PubChem Substance
310264880
ChemSpider
25916
RxNav
6623
ChEBI
29035
ChEMBL
CHEMBL2103742
PDBe Ligand
MN
Drugs.com
Drugs.com Drug Page
Wikipedia
Manganese
AHFS Codes
  • 88:29.00* — Minerals
  • 40:12.00 — Replacement Preparations
PDB Entries
117e / 1a0d / 1a0o / 1a16 / 1a3w / 1a3x / 1a5v / 1a6q / 1a76 / 1a9x
show 3637 more
MSDS
Download (61.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentCentral Serous Chorioretinopathy (CSC)1
2RecruitingTreatmentHigh Grade Glioma, Glioblastoma1
1RecruitingTreatmentMalignant Lymphomas / Tumors, Solid1
1, 2CompletedDiagnosticIschaemic Cardiomyopathy2
1, 2CompletedPreventionDeficiency, Vitamin D / Prophylaxis of preeclampsia1
1, 2RecruitingTreatmentAnal Cancer, Squamous Cell Carcinoma / Nuclear radiation emergency1
1, 2RecruitingTreatmentBiliary Tract Cancer (BTC)1
1, 2RecruitingTreatmentMalignant Neoplasm of Pancreas1
1, 2RecruitingTreatmentOvarian Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, coatedOral1188 mg
CapsuleOral
Tablet, film coated8000 IU
Tablet4000 IU
Capsule4000 IU
Tablet, effervescentOral
SolutionIntravenous2 mg
TabletOral4000 IU
LiquidOral
Tablet, delayed releaseOral
PowderOral
SolutionIntravenous
CapsuleOral30 mg
TabletOral
CapsuleOral
Injection, solutionIntravenous0.1 mg/1mL
KitOral
Tablet, film coatedOral
SolutionIntravenous
LiquidIntravenous
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
Solution, concentrateIntravenous53.3 mcg
Tablet, chewableOral
TabletOral
Capsule, gelatin coatedOral
Capsule, liquid filledOral1 mg
Capsule, liquid filledOral562.85 mg
Tablet, extended releaseOral
Capsule, liquid filledOral25 mg
Capsule, liquid filledOral200 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)1246Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 4-72
boiling point (°C)2061Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 4-72
Predicted Properties
PropertyValueSource
logP-0.16ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-6f3891a406ae3fe4f883
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-6f3891a406ae3fe4f883
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-9000000000-6f3891a406ae3fe4f883
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-9000000000-c3110d268939143a5f80
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-9000000000-c3110d268939143a5f80
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-9000000000-c3110d268939143a5f80

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Nad binding
Specific Function
Not Available
Gene Name
IDH3A
Uniprot ID
P50213
Uniprot Name
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Molecular Weight
39591.365 Da
References
  1. Soundar S, O'hagan M, Fomulu KS, Colman RF: Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28;281(30):21073-81. Epub 2006 May 31. [PubMed:16737955]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Nad binding
Specific Function
Not Available
Gene Name
IDH3G
Uniprot ID
P51553
Uniprot Name
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Molecular Weight
42793.97 Da
References
  1. Soundar S, O'hagan M, Fomulu KS, Colman RF: Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28;281(30):21073-81. Epub 2006 May 31. [PubMed:16737955]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Protein serine/threonine phosphatase activity
Specific Function
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Gene Name
TAB1
Uniprot ID
Q15750
Uniprot Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Molecular Weight
54643.655 Da
References
  1. Conner SH, Kular G, Peggie M, Shepherd S, Schuttelkopf AW, Cohen P, Van Aalten DM: TAK1-binding protein 1 is a pseudophosphatase. Biochem J. 2006 Nov 1;399(3):427-34. [PubMed:16879102]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Manganese ion binding
Specific Function
Not Available
Gene Name
ARG1
Uniprot ID
P05089
Uniprot Name
Arginase-1
Molecular Weight
34734.655 Da
References
  1. Zakharian TY, Di Costanzo L, Christianson DW: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I. Org Biomol Chem. 2008 Sep 21;6(18):3240-3. doi: 10.1039/b811797g. Epub 2008 Aug 6. [PubMed:18802628]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transferrin receptor binding
Specific Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from si...
Gene Name
TF
Uniprot ID
P02787
Uniprot Name
Serotransferrin
Molecular Weight
77063.195 Da
References
  1. Golub MS, Han B, Keen CL: Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte cultures. Brain Res. 1996 May 6;719(1-2):72-7. [PubMed:8782865]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Rna binding
Specific Function
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron whe...
Gene Name
ACO1
Uniprot ID
P21399
Uniprot Name
Cytoplasmic aconitate hydratase
Molecular Weight
98398.14 Da
References
  1. Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. [PubMed:17469137]

Drug created on September 14, 2010 10:21 / Updated on September 20, 2020 08:50

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