Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The... The manufacturer discontinued plicamycin in 2000.
- Mechanism
- Curator reviewed
Plicamycin is presumed to inhibit cellular and enzymic RNA synthesis by forming a complex with DNA. Plicamycin may also lower calcium serum levels by inhibiting the effect of parathyroid hormone upon osteoclasts or by blocking the hypercalcemic action of pharmacologic doses of vitamin D.
- Primary indication
- For the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.Curator reviewed
- Formula / weight
- C52H76O24 · 1085.1454 g/mol (avg)
- Also known as
- Aureolic acid · Mithramycin
- Code names
- A-2371 · ANTIBIOTIC LA-7017 · LA-7017 · NSC-24559 · PA-144
Resolves to
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Which companies are running trials of Plicamycin, in which indications and phases, and which of those programs are still active?
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