Pyrvinium is an anthelmintic agent used for the treatment of pinworm infestations. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate.
- Mechanism
- Curator reviewed · 3 references
Pyrvinium is believed to interfere with glucose uptake by pinworms.
Pyrvinium is also thought to inhibit mitochondrial respiration complex 1 and suppress the unfolded protein response. It is also believed to supress the Wnt pathway by activating casein kinase 1α. These properties have led to the investigation of pyrvinium's activity against cancers like intestinal polyposis.
- Primary indication
- Pyrvinium was once used in the treatment of pinworm infestations.Curator reviewed · 1 structured indication
- Formula / weight
- C26H28N3 · 382.53 g/mol (avg)
- First approval
- Canada, 2001
Resolves to
QMHSXPLYMTVAMK-UHFFFAOYSA-NSMILESCN(C)C1=CC2=C(C=C1)[N+](C)=C(\C=C\C1=C(C)N(C(C)=C1)C1=CC=CC=C1)C=C2What you can answer from here — as of September 19, 2026
Which drugs share a target with Pyrvinium, and which of those have an active Phase 3 trial?
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