Z-Val-Ala-Asp fluoromethyl ketone

DB07744ExperimentalSmall molecule

Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the... It does not require an esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(O-Me) fluoromethyl ketone.

Chemical structure of Z-Val-Ala-Asp fluoromethyl ketone
Formula / weight
C21H28FN3O7 · 453.467 g/mol (avg)
Also known as
Z-VAD-FMK

Resolves to

Compound
CAS161401-82-7ChEMBLCHEMBL205821PubChem5497171
Structure
InChIKeySUUHZYLYARUNIA-YEWWUXTCSA-NSMILESCC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF
Targets
P29466CASP1

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1+ReferenceStructured and connected to the statements they support
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