Identification

Generic Name
Iodamide
DrugBank Accession Number
DB08948
Background

Iodamide is a contrast medium molecule that is no longer marketed in the United States.

Type
Small Molecule
Groups
Withdrawn
Structure
Weight
Average: 627.9402
Monoisotopic: 627.78528711
Chemical Formula
C12H11I3N2O4
Synonyms
  • Ametriiodic acid
  • Ametriiodinic acid
  • Ametriodinic acid
  • Iodamida
  • Iodamide
  • Iodamidum
  • Urombrine
External IDs
  • B 4130
  • B-4130
  • SH 926
  • SH-926

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Iodamide meglumine6X283535A318656-21-8UYIPQECISAQMIU-WZTVWXICSA-N
International/Other Brands
Angiomiron (Schering) / Jodomiron / Renovue / Uromiro / Uromiron (Schering)

Categories

ATC Codes
V08AA03 — Iodamide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as halobenzoic acids. These are benzoic acids carrying a halogen atom on the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzoic acids and derivatives
Direct Parent
Halobenzoic acids
Alternative Parents
2-halobenzoic acids / 4-halobenzoic acids / Benzoic acids / 1-carboxy-2-haloaromatic compounds / Benzoyl derivatives / Iodobenzenes / Aryl iodides / Vinylogous halides / Monocarboxylic acids and derivatives / Carboximidic acids
show 7 more
Substituents
1-carboxy-2-haloaromatic compound / 2-halobenzoic acid / 2-halobenzoic acid or derivatives / 4-halobenzoic acid / 4-halobenzoic acid or derivatives / Aromatic homomonocyclic compound / Aryl halide / Aryl iodide / Benzoic acid / Benzoyl
show 20 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
organoiodine compound, benzoic acids (CHEBI:31703)
Affected organisms
Not Available

Chemical Identifiers

UNII
4RII332O0R
CAS number
440-58-4
InChI Key
VVDGWALACJEJKG-UHFFFAOYSA-N
InChI
InChI=1S/C12H11I3N2O4/c1-4(18)16-3-6-8(13)7(12(20)21)10(15)11(9(6)14)17-5(2)19/h3H2,1-2H3,(H,16,18)(H,17,19)(H,20,21)
IUPAC Name
3-acetamido-5-(acetamidomethyl)-2,4,6-triiodobenzoic acid
SMILES
CC(=O)NCC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I

References

General References
Not Available
KEGG Drug
D01376
PubChem Compound
3723
PubChem Substance
310264914
ChemSpider
3592
RxNav
5928
ChEBI
31703
ChEMBL
CHEMBL1201239
ZINC
ZINC000003830933
Drugs.com
Drugs.com Drug Page
Wikipedia
Iodamide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravesical
Injection, solutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0577 mg/mLALOGPS
logP2.55ALOGPS
logP2.6Chemaxon
logS-4ALOGPS
pKa (Strongest Acidic)2.28Chemaxon
pKa (Strongest Basic)-1.8Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area95.5 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity106.18 m3·mol-1Chemaxon
Polarizability40.78 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at May 27, 2014 17:35 / Updated at February 21, 2021 18:52