Identification
- Summary
Hexetidine is an topical antiseptic agent used for disinfection and prevention of bacterial, fungal and yeast infections of the oral and vaginal mucosa.
- Generic Name
- Hexetidine
- DrugBank Accession Number
- DB08958
- Background
A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Hexetidine (DB08958)
- Weight
- Average: 339.6021
Monoisotopic: 339.361348455 - Chemical Formula
- C21H45N3
- Synonyms
- Esetidina
- Hexetidina
- Hexétidine
- Hexetidine
- Hexetidinum
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Hexetidine. Dicoumarol The therapeutic efficacy of Dicoumarol can be increased when used in combination with Hexetidine. Fluindione The therapeutic efficacy of Fluindione can be increased when used in combination with Hexetidine. Phenindione The therapeutic efficacy of Phenindione can be increased when used in combination with Hexetidine. Phenprocoumon The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Hexetidine. Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Hexetidine. 
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- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Actigrip Gola (Johnson & Johnson) / Bactidol (Johnson & Johnson) / Belosept (Belupo) / Collu-Hextril (Johnson & Johnson) / Hexoral (Johnson & Johnson) / Hextril (Bristol-Myers Squibb) / Isozid-H (Gebro) / Oraldene (McNeil) / Oraldine (Johnson & Johnson) / Steri/Sol (Johnson & Johnson) / Stomatidin (Bosnalijek) / Stopangin (Ivax) / Vagi-Hex (Drossapharm)
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bactidol Mouthwash Mouthwash Oral JOHNSON & JOHNSON SDN BHD 2020-09-08 Not applicable Malaysia 
Steri/sol Liquid Liquid 0.1 % Buccal Johnson & Johnson 1992-12-31 2013-07-31 Canada 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Isozid - H farblos - alkoholische Lösung zur Hautdesinfektion Hexetidine (1 mg) + Isopropyl alcohol (314 mg) + Propyl alcohol (281 mg) Solution Topical Gebro Pharma Gmb H 1994-02-15 Not applicable Austria 
Isozid - H gefärbt - alkoholische Lösung zur Hautdesinfektion Hexetidine (1 mg) + Isopropyl alcohol (314 mg) + Propyl alcohol (281 mg) Solution Topical Gebro Pharma Gmb H 1994-02-15 Not applicable Austria
Categories
- ATC Codes
- G01AX16 — Hexetidine
- G01AX — Other antiinfectives and antiseptics
- G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
- G — GENITO URINARY SYSTEM AND SEX HORMONES
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as diazinanes. These are organic compounds containing diazinane, a six-membered saturated heterocycle containing four carbon atoms and two nitrogen atoms.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Diazinanes
- Sub Class
- Not Available
- Direct Parent
- Diazinanes
- Alternative Parents
- Azacyclic compounds / Aminals / Organopnictogen compounds / Monoalkylamines / Hydrocarbon derivatives
- Substituents
- 1,3-diazinane / Aliphatic heteromonocyclic compound / Aminal / Amine / Azacycle / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound / Primary aliphatic amine
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 852A84Y8LS
- CAS number
- 141-94-6
- InChI Key
- DTOUUUZOYKYHEP-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3
- IUPAC Name
- 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine
- SMILES
- CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1
References
- Synthesis Reference
U.S. Patent 3,054,797.
- General References
- Afennich F, Slot DE, Hossainian N, Van der Weijden GA: The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review. Int J Dent Hyg. 2011 Aug;9(3):182-90. doi: 10.1111/j.1601-5037.2010.00478.x. Epub 2010 Sep 6. [Article]
- Satzinger G, Herrmann W, Zimmermann F: [Analytical profile of purified hexetidine (author's transl)]. Arzneimittelforschung. 1975;25(12):1849-53. [Article]
- External Links
- KEGG Drug
- D07068
- PubChem Compound
- 3607
- PubChem Substance
- 310264923
- ChemSpider
- 3481
- 5301
- ChEBI
- 94339
- ChEMBL
- CHEMBL144673
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Hexetidine
- MSDS
- Download (338 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Mouthwashes / Oral Biofilm / Periodontitis 1 4 Completed Supportive Care Oral Mucositis 1 4 Unknown Status Basic Science Gingivitis / Oral Biofilm / Periodontitis 1 Not Available Completed Prevention Bacteremia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Mouthwash Oral Spray Oral Solution Buccal; Oral 0.1 g Rinse Oral 200 ml Rinse Oral Solution Topical Solution Buccal; Oropharyngeal 0.1 g Liquid Buccal 0.1 % Insert Vaginal 10 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00594 mg/mL ALOGPS logP 4.98 ALOGPS logP 5.74 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 9.08 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 32.5 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 107.4 m3·mol-1 Chemaxon Polarizability 44.07 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available MS/MS Spectrum - , positive LC-MS/MS splash10-0a4i-2900000000-8471a8c759f783c56515
Drug created at May 28, 2014 20:30 / Updated at June 19, 2021 00:27