Beclamide (N-benzyl-B-chloropropionamide) is a no longer used drug that possesses anticonvulsant and sedative activity. It was studied in the 1950s for generalised tonic-clonic seizures but was not effective for absence...
- Mechanism
- Curator reviewed · 1 reference
Beclamide has been used for over three decades with little knowledge of how it acts in the CNS. In one study using rats, beclamide was seen to reduce striatal dopamine and serotonin levels and increase the levels of dopamine's major metabolites (and thus dopamine turnover), while reducing the levels of serotonin's major metabolite below detectable levels. A similar effect on neurotransmitter levels was seen in the rat frontal cortices. It is theorized that animal aggression is linked to levels of biogenic monoamines such as dopamine and serotonin, however the exact role is unclear.
- Primary indication
- Has been used in the management of epilepsy and epilepsy related behavioural disorders.Curator reviewed
- Formula / weight
- C10H12ClNO · 197.661 g/mol (avg)
- Also known as
- Benzchlorpropamide · Benzylamide
Resolves to
JPYQFYIEOUVJDU-UHFFFAOYSA-NSMILESClCCC(=O)NCC1=CC=CC=C1What you can answer from here — as of July 03, 2026
Which drugs share a target with Beclamide, and which of those have an active Phase 3 trial?
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