Carbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone . In the future... In the future this may prevent excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on effectiveness and severity of side effects remains inconclusive.
- Mechanism
- Curator reviewed · 3 references
Carbazochrome interacts with platelet surface α-adrenoreceptors which are Gq-coupled receptors that leads to activation of PLC IP3/DAG pathway and increase in intracellular calcium levels. Elevated calcium ions bind to calmodulin and activates Ca2+/calmodulin-dependent myosin light chain kinase, allowing the myosin crossbridge to bind to the actin filament and polymerisation of globular actin (G-actin) to filamentous actin (F-actin). Subsequent contraction of endothelial cells changes the shape of platelets and promotes the release of factors such as serotonin, ADP, Von Willebrand and platelet activating factor by platelets that induce aggregation and platelet adherence. Carbazochrome is reported to inhibit vascular hyperpermeability by inhibiting agonist-induced phosphoinositides hydrolysis caused by various vasoactive agents such as tryptase, thrombin and bradykinin.
- Primary indication
- Indicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura.Curator reviewed · 4 structured indications
- Formula / weight
- C10H12N4O3 · 236.231 g/mol (avg)
- Also known as
- Adchnon · Adedolon · Adrenostan
- Code names
- EINECS 200-717-0 · NSC 73742
Resolves to
XSXCZNVKFKNLPR-SDQBBNPISA-NSMILESCN1CC(O)C2=C\C(=N\NC(N)=O)C(=O)C=C12What you can answer from here — as of July 03, 2026
Which other approved drugs treat the same conditions as Carbazochrome, and which companies have late-stage candidates in those indications?
Create a free account or log in to explore the full data card.
Create Account