Butriptyline

DB09016ApprovedWithdrawnSmall molecule

Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.

Mechanism: Pharmacologically active on Sodium-dependent serotonin transporter, Histamine H1 receptor, and 5-hydroxytryptamine receptor 2A
Curator reviewed
Code names: AY 2014 · AY-62014

Resolves to

Compound

Clinical / RWD

Targets

What you can answer from here — as of August 30, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,580Drug interactionsStructured to mechanism, not free text

4Marketed productsAcross 1 country and 1 labeller

1ATC codeIncluding every combination product, plus 25 drug categories

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Butriptyline, and which of those have an active Phase 3 trial?

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