Follitropin is a form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism. Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits.
- Mechanism
- Curator reviewed
Follitropin is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
- Primary indication
- In women having been diagnosed with primary ovarian failure, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility.Curator reviewed · 7 structured indications
- Formula / weight
- C975H1513N267O304S26 · 22672.9 Da
- First approval
- Canada, 1997 · United States, 1997 · European Union, 2016
- Also known as
- Follicle stimulating hormone · Follitrophin alfa · Follitrophin alpha · Follitrophin beta · Follitropin alfa
- Code names
- FE 999049
- Brand names
Resolves to
What you can answer from here — as of July 17, 2026
Which drugs share a target with Follitropin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account