Thyroid, porcine is a naturally-occurring peptide hormone used for the replacement therapy for hypothyroidism of any etiology, treatment for euthyroid goiters, and management of thyroid cancers. Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.
- Mechanism
- Curator reviewed · 5 references
T3 binding to the thyroid hormone receptor (TR), changes the conformation of the TR, allowing it to bind to the retinoid X receptor (RXR) and form a coactivator complex. The coactivator complex has histone acetyltransferase activity, which activates genes. In the absence of T3, TR and RXR form a corepressor complex with histone deacetylase activity, which represses genes. The macroscopic effects of thyroid hormones is an increase in the metabolic rate. T4 has similar but weaker activity to T3.
- Primary indication
- Thyroid extract is indicated for replacement therapy in decreased or absent thyroid function.Curator reviewed · 1 structured indication
- First approval
- Canada, 2020
- Also known as
- Pig thyroid · Porcine thyroid · Sus scrofa thyroid · Thyroid (pork) · Thyroid extract, porcine
Resolves to
What you can answer from here — as of April 02, 2025
Which drugs share a target with Thyroid, porcine, and which of those have an active Phase 3 trial?
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