Tandamine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Tandamine
DrugBank Accession Number
DB09192
Background

Tandamine was researched in 1970s as an antidepressant but was never commercialized. Tandamine is an analog of pirandamine and it acts as a selective serotonin reuptake inhibitor (SSRI).

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 302.48
Monoisotopic: 302.181670019
Chemical Formula
C18H26N2S
Synonyms
  • Tandamine
External IDs
  • AY-23,946

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Indoles and derivatives
Sub Class
N-alkylindoles
Direct Parent
N-alkylindoles
Alternative Parents
3-alkylindoles / Aralkylamines / Substituted pyrroles / Benzenoids / Heteroaromatic compounds / Trialkylamines / Dialkylthioethers / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
3-alkylindole / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Dialkylthioether / Heteroaromatic compound / Hydrocarbon derivative / Indole
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
6L5FH5A43E
CAS number
42408-80-0
InChI Key
BRPOADLGOFPKKJ-UHFFFAOYSA-N
InChI
InChI=1S/C18H26N2S/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4/h6-9H,5,10-13H2,1-4H3
IUPAC Name
(2-{9-ethyl-1-methyl-1H,3H,4H,9H-thiopyrano[3,4-b]indol-1-yl}ethyl)dimethylamine
SMILES
CCN1C2=CC=CC=C2C2=C1C(C)(CCN(C)C)SCC2

References

General References
  1. Lippmann W, Pugsley TA: The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities. Biochem Pharmacol. 1976 May 15;25(10):1179-86. [Article]
  2. Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D: Clinical pharmacological studies of tandamine, a potential antidepressive drug. Psychopharmacology (Berl). 1977 Mar 23;52(1):73-7. [Article]
  3. Pugsley TA, Lippmann W: Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities. Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):239-47. [Article]
  4. Pugsley T, Lippmann W: Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities. Psychopharmacology (Berl). 1976 May 5;47(1):33-41. [Article]
  5. Lippmann W, Seethaler K: Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat. Life Sci. 1977 Apr 15;20(8):1393-400. [Article]
PubChem Compound
39187
PubChem Substance
310265100
ChemSpider
35851
ChEMBL
CHEMBL2110652
Wikipedia
Tandamine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0173 mg/mLALOGPS
logP4.74ALOGPS
logP3.59Chemaxon
logS-4.2ALOGPS
pKa (Strongest Basic)9.27Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area8.17 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity94.81 m3·mol-1Chemaxon
Polarizability35.73 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0abi-4290000000-46682194968108912d5b
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0019000000-a60e0d67dc49a263c0d5
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0009000000-b29ee232c571f461deec
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-2279000000-52f2a959547e247789f9
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0zfr-6089000000-f6b6d091be7b76bbe7a3
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0900-0290000000-0552d1d9375935ed10de
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0fl3-3950000000-1b590ce533f0b654900e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-165.79529
predicted
DeepCCS 1.0 (2019)
[M+H]+168.15329
predicted
DeepCCS 1.0 (2019)
[M+Na]+174.24644
predicted
DeepCCS 1.0 (2019)

Drug created at October 16, 2015 19:54 / Updated at February 21, 2021 18:52