Tandamine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Tandamine
- DrugBank Accession Number
- DB09192
- Background
Tandamine was researched in 1970s as an antidepressant but was never commercialized. Tandamine is an analog of pirandamine and it acts as a selective serotonin reuptake inhibitor (SSRI).
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 302.48
Monoisotopic: 302.181670019 - Chemical Formula
- C18H26N2S
- Synonyms
- Tandamine
- External IDs
- AY-23,946
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Indoles and derivatives
- Sub Class
- N-alkylindoles
- Direct Parent
- N-alkylindoles
- Alternative Parents
- 3-alkylindoles / Aralkylamines / Substituted pyrroles / Benzenoids / Heteroaromatic compounds / Trialkylamines / Dialkylthioethers / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- 3-alkylindole / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Dialkylthioether / Heteroaromatic compound / Hydrocarbon derivative / Indole
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 6L5FH5A43E
- CAS number
- 42408-80-0
- InChI Key
- BRPOADLGOFPKKJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H26N2S/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4/h6-9H,5,10-13H2,1-4H3
- IUPAC Name
- (2-{9-ethyl-1-methyl-1H,3H,4H,9H-thiopyrano[3,4-b]indol-1-yl}ethyl)dimethylamine
- SMILES
- CCN1C2=CC=CC=C2C2=C1C(C)(CCN(C)C)SCC2
References
- General References
- Lippmann W, Pugsley TA: The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities. Biochem Pharmacol. 1976 May 15;25(10):1179-86. [Article]
- Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D: Clinical pharmacological studies of tandamine, a potential antidepressive drug. Psychopharmacology (Berl). 1977 Mar 23;52(1):73-7. [Article]
- Pugsley TA, Lippmann W: Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities. Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):239-47. [Article]
- Pugsley T, Lippmann W: Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities. Psychopharmacology (Berl). 1976 May 5;47(1):33-41. [Article]
- Lippmann W, Seethaler K: Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat. Life Sci. 1977 Apr 15;20(8):1393-400. [Article]
- External Links
- PubChem Compound
- 39187
- PubChem Substance
- 310265100
- ChemSpider
- 35851
- ChEMBL
- CHEMBL2110652
- Wikipedia
- Tandamine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0173 mg/mL ALOGPS logP 4.74 ALOGPS logP 3.59 Chemaxon logS -4.2 ALOGPS pKa (Strongest Basic) 9.27 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 8.17 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 94.81 m3·mol-1 Chemaxon Polarizability 35.73 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0abi-4290000000-46682194968108912d5b Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-0019000000-a60e0d67dc49a263c0d5 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-0009000000-b29ee232c571f461deec Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-2279000000-52f2a959547e247789f9 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0zfr-6089000000-f6b6d091be7b76bbe7a3 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0900-0290000000-0552d1d9375935ed10de Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0fl3-3950000000-1b590ce533f0b654900e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 165.79529 predictedDeepCCS 1.0 (2019) [M+H]+ 168.15329 predictedDeepCCS 1.0 (2019) [M+Na]+ 174.24644 predictedDeepCCS 1.0 (2019)
Drug created at October 16, 2015 19:54 / Updated at February 21, 2021 18:52