Talniflumate, is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma . In addition, it is... In addition, it is used in inflammatory conditions such as rheumatoid arthritis.
- Mechanism
- Curator reviewed
Talniflumate is a strong and selective inhibitor of core mucin-synthesizing enzyme GCNT3 (core 2 b-1,6 N-acetylglucosaminyltransferase). Talniflumate decreases gene expression of GCNT3 and production of mucins in vivo and in vitro. Talniflumate improves response of pancreatic tumors to gefitinib (chemotherapy drug). Talniflumate is a strong calcium-activated chloride channel (CaCC) blocker.
- Primary indication
- Talnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis, and has also been studied for...Curator reviewed
- Formula / weight
- C21H13F3N2O4 · 414.34 g/mol (avg)
- Code names
- BA 7602-06
Resolves to
ANMLJLFWUCQGKZ-UHFFFAOYSA-NSMILESFC(F)(F)C1=CC(NC2=C(C=CC=N2)C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1What you can answer from here — as of March 06, 2025
Which drugs share a target with Talniflumate, and which of those have an active Phase 3 trial?
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