Solithromycin

DB09308InvestigationalSmall molecule

Solithromycin is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia (CAP) and other infections.

Mechanism: Pharmacologically active on Bacterial 50S ribosomal protein
Curator reviewed
Primary indication: Investigated for the treatment of community-acquired pneumonia (CAP).Curator reviewed
Formula / weight: C₄₃H₆₅FN₆O₁₀ · 845.0088 g/mol (avg)
Code names: CEM-101 · OP-1068

Resolves to

Compound

UNII9U1ETH79CKCAS760981-83-7ChEMBLCHEMBL1232510PubChem25242512

Clinical / RWD

ATCJ01FA16

Structure

InChIKeyIXXFZUPTQVDPPK-ZAWHAJPISA-NSMILES

[H][C@]12N(CCCCN3C=C(N=N3)C3=CC(N)=CC=C3)C(=O)O[C@]1(C)[C@@]([H])(CC)OC(=O)[C@@](C)(F)C(=O)[C@]([H])(C)[C@@]([H])(O[C@]1([H])O[C@]([H])(C)C[C@]([H])(N(C)C)[C@@]1([H])O)[C@@](C)(C[C@@]([H])(C)C(=O)[C@]2([H])C)OC

Transporters

P08183ABCB1

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

317Drug interactionsStructured to mechanism, not free text

9Clinical trialsPhase, status and sponsor resolved per trial

1ATC codeIncluding every combination product, plus 23 drug categories

14+ReferencesStructured and connected to the statements they support

Which companies are running trials of Solithromycin, in which indications and phases, and which of those programs are still active?

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