Identification
- Summary
Xenon-133 is an inhaled radionuclide used to measure lung function and organ blood flow.
- Generic Name
- Xenon-133
- DrugBank Accession Number
- DB09315
- Background
Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Xenon-133 (DB09315)
- Weight
- Average: 132.9059
Monoisotopic: 132.90590566 - Chemical Formula
- Xe
- Synonyms
- Xenon (133 xe)
- Xenon (133Xe)
- Xenon (133Xe) gas
- Xenon Xe 133
- Xenon XE-133
- Xenon, Xe-133
Pharmacology
- Indication
Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes and freely exchanges between blood and tissue. It tends to concentrate more in body fat than in blood, plasma, water or protein solutions.
- Mechanism of action
Xenon-133 is used for the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. In the concentrations used for diagnostic purposes it is physiologically inactive.
- Absorption
Inhaled Xenon Xe 133 Gas will enter the alveolar wall and enter the pulmonary venous circulation via the capillaries.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Most of the Xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.
- Half-life
Half Life 5.245 days
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Xenon Gas 10 mCi/1 Respiratory (inhalation) Lantheus Medical Imaging, Inc. 1974-10-10 Not applicable US 
Xenon Gas 40 mCi/1 Respiratory (inhalation) Bristol-Myers Squibb 2007-12-20 2007-12-20 US Xenon Gas 30 mCi/1 Respiratory (inhalation) Bristol-Myers Squibb 2007-12-20 2007-12-20 US Xenon Gas 100 mCi/1 Respiratory (inhalation) Bristol-Myers Squibb 2007-12-20 2007-12-20 US Xenon Gas 20 mCi/1 Respiratory (inhalation) Lantheus Medical Imaging, Inc. 1974-10-10 Not applicable US
Categories
- ATC Codes
- V09EX03 — Xenon (133xe) gas
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Homogeneous noble gases
- Sub Class
- Not Available
- Direct Parent
- Homogeneous noble gases
- Alternative Parents
- Not Available
- Substituents
- Homogeneous noble gas
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- X3P9A5HNYF
- CAS number
- 14932-42-4
- InChI Key
- FHNFHKCVQCLJFQ-NJFSPNSNSA-N
- InChI
- InChI=1S/Xe/i1+2
- IUPAC Name
- (¹³³Xe)xenon
- SMILES
- [133Xe]
References
- General References
- FDA label [Link]
- External Links
- PubChem Compound
- 66376
- PubChem Substance
- 310265200
- ChemSpider
- 59751
- 259282
- ChEMBL
- CHEMBL1200685
- Wikipedia
- Isotopes_of_xenon
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Terminated Diagnostic Pulmonary Embolism 1 3 Terminated Other Lung Structure Determination 1 1, 2 Recruiting Diagnostic Chronic Obstructive Pulmonary Disease (COPD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gas Respiratory (inhalation) 10 mCi/1 Gas Respiratory (inhalation) 100 mCi/1 Gas Respiratory (inhalation) 20 mCi/1 Gas Respiratory (inhalation) 30 mCi/1 Gas Respiratory (inhalation) 40 mCi/1 Gas Respiratory (inhalation) 50 mCi/1 Gas Respiratory (inhalation) 10 mCi/1mL Gas Respiratory (inhalation) 5 mCi/1mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 16, 2015 23:06 / Updated at June 12, 2020 17:42