Identification

Summary

Xenon-133 is an inhaled radionuclide used to measure lung function and organ blood flow.

Generic Name
Xenon-133
DrugBank Accession Number
DB09315
Background

Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 132.9059
Monoisotopic: 132.90590566
Chemical Formula
Xe
Synonyms
  • Xenon (133 xe)
  • Xenon (133Xe)
  • Xenon (133Xe) gas
  • Xenon Xe 133
  • Xenon XE-133
  • Xenon, Xe-133

Pharmacology

Indication

Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes and freely exchanges between blood and tissue. It tends to concentrate more in body fat than in blood, plasma, water or protein solutions.

Mechanism of action

Xenon-133 is used for the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. In the concentrations used for diagnostic purposes it is physiologically inactive.

Absorption

Inhaled Xenon Xe 133 Gas will enter the alveolar wall and enter the pulmonary venous circulation via the capillaries.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Most of the Xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.

Half-life

Half Life 5.245 days

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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dosage, form, labeller, route of administration, and marketing period.
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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
XenonGas100 mCi/1Respiratory (inhalation)Bristol-Myers Squibb2007-12-202007-12-20US flag
XenonGas30 mCi/1Respiratory (inhalation)Bristol-Myers Squibb2007-12-202007-12-20US flag
XenonGas20 mCi/1Respiratory (inhalation)Lantheus Medical Imaging, Inc.1974-10-10Not applicableUS flag
XenonGas50 mCi/1Respiratory (inhalation)Bristol-Myers Squibb2007-12-202007-12-20US flag
XenonGas10 mCi/1Respiratory (inhalation)Lantheus Medical Imaging, Inc.1974-10-10Not applicableUS flag
XenonGas40 mCi/1Respiratory (inhalation)Bristol-Myers Squibb2007-12-202007-12-20US flag
Xenon, Xe-133Gas10 mCi/1mLRespiratory (inhalation)Curium US LLC2016-03-30Not applicableUS flag
Xenon, Xe-133Gas10 mCi/1mLRespiratory (inhalation)Mallinckrodt1982-03-092010-09-01US flag
Xenon, Xe-133Gas5 mCi/1mLRespiratory (inhalation)Curium US LLC2016-03-30Not applicableUS flag
Xenon, Xe-133Gas5 mCi/1mLRespiratory (inhalation)Mallinckrodt1982-03-092010-09-01US flag

Categories

ATC Codes
V09EX03 — Xenon (133xe) gas
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous noble gases
Sub Class
Not Available
Direct Parent
Homogeneous noble gases
Alternative Parents
Not Available
Substituents
Homogeneous noble gas
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
X3P9A5HNYF
CAS number
14932-42-4
InChI Key
FHNFHKCVQCLJFQ-NJFSPNSNSA-N
InChI
InChI=1S/Xe/i1+2
IUPAC Name
(¹³³Xe)xenon
SMILES
[133Xe]

References

General References
  1. FDA label [Link]
PubChem Compound
66376
PubChem Substance
310265200
ChemSpider
59751
RxNav
259282
ChEMBL
CHEMBL1200685
Wikipedia
Isotopes_of_xenon

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedDiagnosticPulmonary Embolism1
3TerminatedOtherLung Structure Determination1
1, 2RecruitingDiagnosticChronic Obstructive Pulmonary Disease (COPD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GasRespiratory (inhalation)10 mCi/1
GasRespiratory (inhalation)100 mCi/1
GasRespiratory (inhalation)20 mCi/1
GasRespiratory (inhalation)30 mCi/1
GasRespiratory (inhalation)40 mCi/1
GasRespiratory (inhalation)50 mCi/1
GasRespiratory (inhalation)10 mCi/1mL
GasRespiratory (inhalation)5 mCi/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at November 16, 2015 23:06 / Updated at June 12, 2020 17:42