Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Gastric intrinsic factor
- DrugBank Accession Number
- DB09349
- Background
Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. When vitamin B12 is provided in combination with intrinsic factor, intrinsic factor reduces protease degradation and increases absorption of Vitamin B12.
Intrinsic factor is not currently available in any FDA or Health Canada approved products. However, it is currently in the marketed (but unapproved) product Hematogen in combination with cyanocobalamin (synthetic Vitamin B12), ferrous fumarate, and ascorbic acid for the treatment of anemias responsive to oral iron therapy.
- Type
- Biotech
- Groups
- Approved, Experimental
- Biologic Classification
- Protein Based Therapies
Other protein based therapies - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Intrinsic factor
Pharmacology
- Indication
Intrinsic factor is not currently available in any FDA or Health Canada approved products. However, it is currently in the marketed (but unapproved) product Hematogen in combination with cyanocobalamin (synthetic Vitamin B12), ferrous fumarate, and ascorbic acid for the treatment of anemias responsive to oral iron therapy.
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. When vitamin B12 is provided in combination with intrinsic factor, intrinsic factor reduces protease degradation and increases absorption of Vitamin B12.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
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- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Biopar delta-FORTE Gastric intrinsic factor (50 mg/1) + Cobalamin (50 ug/1) + Cobamamide (50 ug/1) + Dihydrofolic Acid (1 mg/1) + Levoleucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1) Capsule Oral Jaymac Pharmaceuticals Llc 2024-06-01 Not applicable US 
Chromagen Gastric intrinsic factor (100 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (10 ug/1) + Ferrous asparto glycinate (25 mg/1) + Ferrous fumarate (50 mg/1) + Folic acid (250 ug/1) + Levomefolic acid (750 ug/1) + Zinc (12 mg/1) Capsule Oral Avion Pharmaceuticals, Llc 2017-01-10 Not applicable US EnLyte Extra-LN Gastric intrinsic factor (25 mg/1) + Cobamamide (25 ug/1) + Dihydrofolic Acid (1 mg/1) + Mecobalamin (25 ug/1) Capsule Oral Jaymac Pharmacueticals LLC 2019-12-16 Not applicable US Hematogen Gastric intrinsic factor (100 mg/1) + Ascorbic acid (250 mg/1) + Cyanocobalamin (10 ug/1) + Ferrous fumarate (66 mg/1) Capsule Oral Nnodum Pharmaceuticals 2007-05-10 Not applicable US 
Niferex Gastric intrinsic factor (100 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (25 ug/1) + Ferrous asparto glycinate (50 mg/1) + Folic acid (250 ug/1) + Iron Dextran (100 mg/1) + Levomefolic acid (750 ug/1) + Succinic acid (50 mg/1) + Zinc (15 mg/1) Tablet Oral Avion Pharmaceuticals, Llc 2017-01-10 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 70BT6OQT2Q
- CAS number
- Not Available
References
- General References
- Not Available
- External Links
- PubChem Substance
- 347910446
- 5920
- Wikipedia
- Intrinsic_factor
- FDA label
- Download (1.53 MB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data4 Recruiting Treatment Iron Deficiency Anemia of Pregnancy / Iron Storage Disease 1 somestatus stop reason just information to hide 4 Terminated Treatment Anemia 1 somestatus stop reason just information to hide 2 Completed Diagnostic Vitamin B12 Deficiency 1 somestatus stop reason just information to hide 1, 2 Unknown Status Treatment Postpartum Anemia 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Tablet Oral Tablet, chewable Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Drug created at November 27, 2015 23:06 / Updated at September 28, 2021 21:54