Identification

Generic Name
Gastric intrinsic factor
DrugBank Accession Number
DB09349
Background

Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. When vitamin B12 is provided in combination with intrinsic factor, intrinsic factor reduces protease degradation and increases absorption of Vitamin B12.

Intrinsic factor is not currently available in any FDA or Health Canada approved products. However, it is currently in the marketed (but unapproved) product Hematogen in combination with cyanocobalamin (synthetic Vitamin B12), ferrous fumarate, and ascorbic acid for the treatment of anemias responsive to oral iron therapy.

Type
Biotech
Groups
Approved, Experimental
Biologic Classification
Protein Based Therapies
Other protein based therapies
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Intrinsic factor

Pharmacology

Indication

Intrinsic factor is not currently available in any FDA or Health Canada approved products. However, it is currently in the marketed (but unapproved) product Hematogen in combination with cyanocobalamin (synthetic Vitamin B12), ferrous fumarate, and ascorbic acid for the treatment of anemias responsive to oral iron therapy.

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action

Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. When vitamin B12 is provided in combination with intrinsic factor, intrinsic factor reduces protease degradation and increases absorption of Vitamin B12.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Images
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Biopar delta-FORTEGastric intrinsic factor (50 mg/1) + Cobalamin (50 ug/1) + Cobamamide (50 ug/1) + Dihydrofolic Acid (1 mg/1) + Levoleucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1)CapsuleOralJaymac Pharmacueticals LLC2020-09-01Not applicableUS flag
ChromagenGastric intrinsic factor (100 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (10 ug/1) + Ferrous asparto glycinate (25 mg/1) + Ferrous fumarate (50 mg/1) + Folic acid (250 ug/1) + Levomefolic acid (750 ug/1) + Zinc (12 mg/1)CapsuleOralAvion Pharmaceuticals, Llc2017-01-10Not applicableUS flag
EnLyte Extra-LNGastric intrinsic factor (25 mg/1) + Cobamamide (25 ug/1) + Dihydrofolic Acid (1 mg/1) + Mecobalamin (25 ug/1)CapsuleOralJaymac Pharmacueticals LLC2019-12-16Not applicableUS flag
HematogenGastric intrinsic factor (100 mg/1) + Ascorbic acid (250 mg/1) + Cyanocobalamin (10 ug/1) + Ferrous fumarate (66 mg/1)CapsuleOralNnodum Pharmaceuticals2007-05-10Not applicableUS flag63044 0631 19 nlmimage10 23409194
NiferexGastric intrinsic factor (100 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (25 ug/1) + Ferrous asparto glycinate (50 mg/1) + Folic acid (250 ug/1) + Iron Dextran (100 mg/1) + Levomefolic acid (750 ug/1) + Succinic acid (50 mg/1) + Zinc (15 mg/1)TabletOralAvion Pharmaceuticals, Llc2017-01-10Not applicableUS flag
PuralorGastric intrinsic factor (2.5 mg/1) + 1-(c14-c18 esteroyl)-2-docosahexanoyl-sn-glycero-3-phosphocholine (5 mg/1) + 1-(c14-c18 esteroyl)-2-docosahexanoyl-sn-glycero-3-phosphoethanolamine (2.5 mg/1) + Acetylcysteine amide (5 mg/1) + Ascorbic acid (25 mg/1) + Cholecalciferol (100 [iU]/1) + Citric acid (1.6 mg/1) + Cobamamide (2 mg/1) + Egg phospholipids (42.5 mg/1) + Folic acid (42.5 mg/1) + Magnesium L-threonate (2.5 mg/1) + Leucovorin (3 mg/1) + Levomefolic acid (0.4 mg/1) + Magnesium glycinate (1 mg/1) + Niacin (0.5 mg/1) + Pantethine (2.5 mg/1) + Papain (20 mg/1) + Riboflavin (0.5 mg/1) + Sodium citrate (0.8 mg/1) + Thiamine chloride (0.5 mg/1)Tablet, chewableOralCenturion Labs2014-01-012017-09-20US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
70BT6OQT2Q
CAS number
Not Available

References

General References
Not Available
PubChem Substance
347910446
RxNav
5920
Wikipedia
Intrinsic_factor
FDA label
Download (1.53 MB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4TerminatedTreatmentAnemia1
2CompletedDiagnosticVitamin B12 Deficiency1
1, 2Unknown StatusTreatmentPostpartum Anemia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
TabletOral
Tablet, chewableOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Drug created at November 27, 2015 23:06 / Updated at September 28, 2021 21:54