Dipotassium phosphate

Identification

Name
Dipotassium phosphate
Accession Number
DB09414
Description

Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 174.1759
Monoisotopic: 173.888658754
Chemical Formula
HK2O4P
Synonyms
  • Di-potassium hydrogen phosphate
  • Dibasic potassium phosphate
  • Dipotassium acid phosphate
  • Dipotassium hydrogen monophosphate
  • Dipotassium hydrogen orthophosphate
  • Dipotassium hydrogen phosphate
  • Dipotassium monophosphate
  • Kali phosphoricum
  • Phosphoric acid, dipotassium salt
  • Phosphoric acid, potassium salt (1:2)
  • Potassium phosphate dibasic
  • Potassium phosphate, dibasic
  • Potassium phosphate,dibasic
  • Secondary potassium phosphate
External IDs
  • 231-834-5
  • E-340(II)
  • INS no.340(II)
  • INS-340(II)

Pharmacology

Pharmacology
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Indication

Dipotassium phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures as an additive. It is used in non-dairy creamers to prevent coagulation. Dipotassium phosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

Mechanism of action

Once phosphate gains access to the body fluids and tissues, it exerts little pharmacological effect. If the ion is introduced into the intestine, the absorbed phosphate is rapidly excreted. If large amounts are given by this route, much of it may escape absorption. Because this property leads to a cathartic action, phosphate salts are employed as mild laxatives.

Absorption

Potassium salts are well absorbed from gastro intestinal tract. Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses.

Volume of distribution

Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity.

Protein binding

Phosphate is minimally protein bound, and highly concentrated in cells (intracellular concentrations are 100-fold higher than serum concentrations). Concentrations of phosphate in plasma are higher in children than in adults.

Metabolism

Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues.

Route of elimination

Potassium is excreted primarily by kidney.

Half-life

In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.

Clearance

Phosphates are rapidly cleared by dialysis.

Adverse Effects
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Toxicity

LD50 not available. Toxic effects in humans: Irritated skin, eye. Gastro intestinal irritation with nausea, vomiting, diarrhea, abdominal discomfort

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololDipotassium phosphate may increase the hyperkalemic activities of Acebutolol.
AceclofenacDipotassium phosphate may increase the hyperkalemic activities of Aceclofenac.
AcemetacinDipotassium phosphate may increase the hyperkalemic activities of Acemetacin.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Dipotassium phosphate.
Acetylsalicylic acidDipotassium phosphate may increase the hyperkalemic activities of Acetylsalicylic acid.
AclidiniumThe therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Aclidinium.
AlclofenacDipotassium phosphate may increase the hyperkalemic activities of Alclofenac.
AlfentanilThe therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Alfentanil.
AliskirenDipotassium phosphate may increase the hyperkalemic activities of Aliskiren.
AlloinThe risk or severity of adverse effects can be increased when Dipotassium phosphate is combined with Alloin.
Interactions
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Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Phosphate ionionicNK08V8K8HR14265-44-2NBIIXXVUZAFLBC-UHFFFAOYSA-K
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
2.5% Travasol Amino Acid Injection With Electrolytes In 10% DextroseDipotassium phosphate (130.5 mg) + Alanine (520 mg) + Arginine (290 mg) + Dextrose, unspecified form (10 g) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + Leucine (182.5 mg) + Lysine (145 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Phenylalanine (140 mg) + Proline (170 mg) + Serine (125 mg) + Sodium acetate (170 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (145 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose ClinimixDipotassium phosphate (130.5 mg) + Alanine (520 mg) + Arginine (260 mg) + Dextrose, unspecified form (10 g) + Glycine (520 mg) + Histidine (110 mg) + Isoleucine (120 mg) + L-Leucine hydrochloride (155 mg) + Lysine hydrochloride (145 mg) + Magnesium chloride (25.5 mg) + Methionine (145 mg) + Phenylalanine hydrochloride (155 mg) + Proline (105 mg) + Sodium acetate (170 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (115 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312015-08-05Canada flag
2.5%travasol Amino Acid InJ.W.eleC.W.25%dexDipotassium phosphate (130.5 mg) + Alanine (520 mg) + Arginine (290 mg) + Dextrose, unspecified form (25 g) + Glycine (260 mg) + Histidine (120 mg) + Isoleucine (150 mg) + Leucine (182.5 mg) + Lysine (145 mg) + Magnesium chloride (25.5 mg) + Methionine (100 mg) + Phenylalanine (140 mg) + Proline (170 mg) + Serine (125 mg) + Sodium acetate (170 mg) + Sodium chloride (29.3 mg) + Threonine (105 mg) + Tryptophan (45 mg) + Tyrosine (10 mg) + Valine (145 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada flag
2.75% Travas. Amino Acid InJ.W.elecw.25%dexDipotassium phosphate (261 mg) + Alanine (570 mg) + Arginine (316 mg) + Dextrose, unspecified form (25 g) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + Leucine (201 mg) + Lysine (159.5 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Phenylalanine (154 mg) + Proline (187 mg) + Serine (137.5 mg) + Sodium acetate (215.5 mg) + Sodium chloride (112 mg) + Threonine (115.5 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (159.5 mg)LiquidIntravenousClintec Nutrition Company1996-07-301998-08-13Canada flag
2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose QuickmixDipotassium phosphate (261 mg) + Alanine (570 mg) + Arginine (285 mg) + Dextrose, unspecified form (25 g) + Glycine (570 mg) + Histidine (120.5 mg) + Isoleucine (131.5 mg) + L-Leucine hydrochloride (170 mg) + Lysine hydrochloride (159 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Phenylalanine hydrochloride (170 mg) + Proline (115 mg) + Sodium acetate (215.5 mg) + Sodium chloride (112 mg) + Threonine (115 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (126 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-02-022007-08-02Canada flag
2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose QuickmixDipotassium phosphate (215.5 mg) + Alanine (570 mg) + Arginine (285 mg) + Dextrose, unspecified form (5 g) + Glycine (570 mg) + Histidine (120.5 mg) + Isoleucine (131.5 mg) + L-Leucine hydrochloride (170 mg) + Lysine hydrochloride (159 mg) + Magnesium chloride (51 mg) + Methionine (159 mg) + Phenylalanine hydrochloride (170 mg) + Proline (115 mg) + Sodium acetate (256 mg) + Sodium chloride (112 mg) + Threonine (115 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (126 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1993-12-312007-08-02Canada flag
2.75%travasol Amino Acid InJ.W.eleC.W.5%dex.Dipotassium phosphate (261 mg) + Alanine (570 mg) + Arginine (316 mg) + Dextrose, unspecified form (5 g) + Glycine (283 mg) + Histidine (132 mg) + Isoleucine (165 mg) + Leucine (201 mg) + Lysine (159.5 mg) + Magnesium chloride (51 mg) + Methionine (110 mg) + Phenylalanine (154 mg) + Proline (187 mg) + Serine (137.5 mg) + Sodium acetate (215 mg) + Sodium chloride (112 mg) + Threonine (115.5 mg) + Tryptophan (49.5 mg) + Tyrosine (11 mg) + Valine (159.5 mg)LiquidIntravenousClintec Nutrition Company1996-12-311999-08-10Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 10% DextroseDipotassium phosphate (261 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (10 g) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + Leucine (310 mg) + Lysine hydrochloride (246.5 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Serine (212.5 mg) + Sodium acetate (297 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312015-08-05Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 20% DextroseDipotassium phosphate (261 mg) + Alanine (880 mg) + Arginine (489 mg) + Dextrose, unspecified form (20 g) + Glycine (438 mg) + Histidine (204 mg) + Isoleucine (255 mg) + Leucine (310 mg) + Lysine hydrochloride (246.5 mg) + Magnesium chloride (51 mg) + Methionine (170 mg) + Phenylalanine (238 mg) + Proline (289 mg) + Serine (212.5 mg) + Sodium acetate (297 mg) + Sodium chloride (77 mg) + Threonine (178.5 mg) + Tryptophan (76.5 mg) + Tyrosine (17 mg) + Valine (246.5 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1996-12-312007-08-02Canada flag
4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose QuickmixDipotassium phosphate (261 mg) + Alanine (880 mg) + Arginine (440 mg) + Dextrose, unspecified form (20 g) + Glycine (880 mg) + Histidine (186 mg) + Isoleucine (203 mg) + L-Leucine hydrochloride (263 mg) + Lysine hydrochloride (246 mg) + Magnesium chloride (51 mg) + Methionine (246 mg) + Phenylalanine hydrochloride (263 mg) + Proline (178 mg) + Sodium acetate (297 mg) + Sodium chloride (77 mg) + Threonine (178 mg) + Tryptophan (76 mg) + Tyrosine (17 mg) + Valine (195 mg)SolutionIntravenousBaxter Corporation Clintec Nutrition Division1995-12-312007-08-02Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BIOFLEKS IZOLEKS-M %5 DEKS 250 ML SOLUSYON SETSIZDipotassium phosphate (0.13 g/100ml) + D-glucose monohydrate (5 g/100ml) + Potassium chloride (0.15 g/100ml) + Sodium acetate (0.28 g/100ml) + Sodium chloride (0.091 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-M %5 DEKSTROZ BIOSEL SOL (PVC TORBA) 1000 ML SETLIDipotassium phosphate (0.13 g/100ml) + D-glucose monohydrate (5 g/100ml) + Potassium chloride (0.15 g/100ml) + Sodium acetate (0.28 g/100ml) + Sodium chloride (0.091 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-M %5 DEKSTROZ BIOSEL SOL 250 ML SETLIDipotassium phosphate (0.13 g/100ml) + D-glucose monohydrate (5 g/100ml) + Potassium chloride (0.15 g/100ml) + Sodium acetate (0.28 g/100ml) + Sodium chloride (0.091 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-M %5 DEKSTROZ BIOSEL SOL 500 ML SETLIDipotassium phosphate (0.13 g/100ml) + D-glucose monohydrate (5 g/100ml) + Potassium chloride (0.15 g/100ml) + Sodium acetate (0.28 g/100ml) + Sodium chloride (0.091 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-M %5DEKS 1000 ML SOLUSYON (PVC TORBA) SETSIZDipotassium phosphate (0.13 g/100ml) + D-glucose monohydrate (5 g/100ml) + Potassium chloride (0.15 g/100ml) + Sodium acetate (0.28 g/100ml) + Sodium chloride (0.091 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-M %5DEKS 500 ML SOLUSYON SETSIZDipotassium phosphate (0.13 g/100ml) + D-glucose monohydrate (5 g/100ml) + Potassium chloride (0.15 g/100ml) + Sodium acetate (0.28 g/100ml) + Sodium chloride (0.091 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-P %5 DEKSTROZ SOL 250 ML SETLIDipotassium phosphate (0.026 g/100ml) + D-glucose monohydrate (5 g/100ml) + Sodium lactate (0.26 g/100ml) + Magnesium chloride hexahydrate (0.031 g/100ml) + Potassium chloride (0.13 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-P %5 DEKSTROZ SOL 500 ML SETLIDipotassium phosphate (0.026 g/100ml) + D-glucose monohydrate (5 g/100ml) + Sodium lactate (0.26 g/100ml) + Magnesium chloride hexahydrate (0.031 g/100ml) + Potassium chloride (0.13 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-S PH 7.4 SOL (PVC TORBA) 500 ML SETLIDipotassium phosphate (0.012 g/100ml) + Sodium gluconate (0.5 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Monopotassium phosphate (0.00082 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
BIOFLEKS IZOLEKS-S PH7.4 500 ML SOLUSYON (PVC TORBA) SETSIZDipotassium phosphate (0.012 g/100ml) + Sodium gluconate (0.5 g/100ml) + Magnesium chloride hexahydrate (0.03 g/100ml) + Monopotassium phosphate (0.00082 g/100ml) + Potassium chloride (0.037 g/100ml) + Sodium acetate trihydrate (0.37 g/100ml) + Sodium chloride (0.53 g/100ml)SolutionIntravenousOSEL İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal phosphates
Direct Parent
Alkali metal phosphates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkali metal phosphate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
organic molecular entity (CHEBI:32031)

Chemical Identifiers

UNII
CI71S98N1Z
CAS number
7758-11-4
InChI Key
ZPWVASYFFYYZEW-UHFFFAOYSA-L
InChI
InChI=1S/2K.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
IUPAC Name
dipotassium hydrogen phosphate
SMILES
[K+].[K+].OP([O-])([O-])=O

References

General References
  1. Pubchem [Link]
  2. Toxnet [Link]
  3. MSDS [Link]
KEGG Compound
C13197
PubChem Compound
24450
PubChem Substance
347827847
ChemSpider
22858
RxNav
55018
ChEBI
131527
ChEMBL
CHEMBL1200459
Wikipedia
Dipotassium_phosphate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3TerminatedTreatmentHyposalivation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntravenous
LiquidBuccal
SolutionIntravenous
SprayOral
Aerosol, sprayOral
LiquidIntravesical
PowderOral
Injection, solution, concentrateIntravenous
LiquidIntravenous
AerosolOral
InjectionIntravenous
Powder, for solutionOral
SolutionIntravenous87.1 mg/1ml
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US10632150No2019-04-192039-04-19US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area83.42 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity12.41 m3·mol-1ChemAxon
Polarizability5.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created on November 30, 2015 19:10 / Updated on June 12, 2020 16:52