This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Iotrolan
DrugBank Accession Number
DB09487
Background

Nonionic, isotonic contrast medium designed for intrathecal use.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 1626.242
Monoisotopic: 1625.72933
Chemical Formula
C37H48I6N6O18
Synonyms
  • Iotrolan
  • Iotrolanum
  • Iotrolum
External IDs
  • DL 3-117
  • DL-3117
  • ZK 39 482
  • ZK-39-482
  • ZK-39482

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Iotrovist / Isovist / Osmovist / Osmovist 190 / Osmovist 240
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Osmovist 240 - Liq Int 513mg/mlSolution240 mg / mLIntrathecalBayer1996-11-082009-08-06Canada flag
Osmovist 300 - Liq Int 641mg/mlSolution300 mg / mLIntrathecalBayer1996-11-082009-08-06Canada flag

Categories

ATC Codes
V08AB06 — Iotrolan
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
16FL47B687
CAS number
79770-24-4
InChI Key
XUHXFSYUBXNTHU-UHFFFAOYSA-N
InChI
InChI=1S/C37H48I6N6O18/c1-48(32-28(40)22(34(64)44-12(4-50)16(58)8-54)26(38)23(29(32)41)35(65)45-13(5-51)17(59)9-55)20(62)3-21(63)49(2)33-30(42)24(36(66)46-14(6-52)18(60)10-56)27(39)25(31(33)43)37(67)47-15(7-53)19(61)11-57/h12-19,50-61H,3-11H2,1-2H3,(H,44,64)(H,45,65)(H,46,66)(H,47,67)
IUPAC Name
2,4,6-triiodo-5-{N-methyl-2-[methyl({2,4,6-triiodo-3,5-bis[(1,3,4-trihydroxybutan-2-yl)carbamoyl]phenyl})carbamoyl]acetamido}-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
SMILES
CN(C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I

References

General References
Not Available
KEGG Drug
D01714
ChemSpider
3607
RxNav
51474
ChEBI
31715
ChEMBL
CHEMBL1200555
Wikipedia
Iotrolan

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntrathecal240 mg / mL
SolutionIntrathecal300 mg / mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.539 mg/mLALOGPS
logP-3.3ALOGPS
logP-3.7ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)11.5ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count18ChemAxon
Hydrogen Donor Count16ChemAxon
Polar Surface Area399.78 Å2ChemAxon
Rotatable Bond Count24ChemAxon
Refractivity290.72 m3·mol-1ChemAxon
Polarizability116.79 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at November 30, 2015 19:10 / Updated at February 21, 2021 18:52