Iotrolan
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Iotrolan
- DrugBank Accession Number
- DB09487
- Background
Nonionic, isotonic contrast medium designed for intrathecal use.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 1626.242
Monoisotopic: 1625.72933 - Chemical Formula
- C37H48I6N6O18
- Synonyms
- Iotrolan
- Iotrolanum
- Iotrolum
- External IDs
- DL 3-117
- DL-3117
- ZK 39 482
- ZK-39-482
- ZK-39482
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Iotrovist / Isovist / Osmovist / Osmovist 190 / Osmovist 240
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Osmovist 240 - Liq Int 513mg/ml Solution 240 mg / mL Intrathecal Bayer 1996-11-08 2009-08-06 Canada Osmovist 300 - Liq Int 641mg/ml Solution 300 mg / mL Intrathecal Bayer 1996-11-08 2009-08-06 Canada
Categories
- ATC Codes
- V08AB06 — Iotrolan
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 16FL47B687
- CAS number
- 79770-24-4
- InChI Key
- XUHXFSYUBXNTHU-UHFFFAOYSA-N
- InChI
- InChI=1S/C37H48I6N6O18/c1-48(32-28(40)22(34(64)44-12(4-50)16(58)8-54)26(38)23(29(32)41)35(65)45-13(5-51)17(59)9-55)20(62)3-21(63)49(2)33-30(42)24(36(66)46-14(6-52)18(60)10-56)27(39)25(31(33)43)37(67)47-15(7-53)19(61)11-57/h12-19,50-61H,3-11H2,1-2H3,(H,44,64)(H,45,65)(H,46,66)(H,47,67)
- IUPAC Name
- 2,4,6-triiodo-5-{N-methyl-2-[methyl({2,4,6-triiodo-3,5-bis[(1,3,4-trihydroxybutan-2-yl)carbamoyl]phenyl})carbamoyl]acetamido}-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
- SMILES
- CN(C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I
References
- General References
- Not Available
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intrathecal 240 mg / mL Solution Intrathecal 300 mg / mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.539 mg/mL ALOGPS logP -3.3 ALOGPS logP -3.7 Chemaxon logS -3.5 ALOGPS pKa (Strongest Acidic) 11.5 Chemaxon pKa (Strongest Basic) -3.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 18 Chemaxon Hydrogen Donor Count 16 Chemaxon Polar Surface Area 399.78 Å2 Chemaxon Rotatable Bond Count 24 Chemaxon Refractivity 290.72 m3·mol-1 Chemaxon Polarizability 116.79 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 344.2083 predictedDeepCCS 1.0 (2019) [M+H]+ 346.10373 predictedDeepCCS 1.0 (2019) [M+Na]+ 351.88168 predictedDeepCCS 1.0 (2019)
Drug created at November 30, 2015 19:10 / Updated at February 21, 2021 18:52