Dexchlorpheniramine maleate is a first generation antihistamine used to treat allergic and vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema. Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine.
- Mechanism
- Curator reviewed
Competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. Dexchlorpheniramine is the predominant active isomer of chlorpheniramine and is approximately twice as active as the racemic compound.
- Primary indication
- Dexchlorpheniramine can be used in the treatment of perennial and seasonal allergic rhinitis, vasomotor rhiniti, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic...Curator reviewed · 8 structured indications
- Formula / weight
- C20H23ClN2O4 · 390.86 g/mol (avg)
- First approval
- Canada, 1958 · United States, 1984
- Brand names
Resolves to
DBAKFASWICGISY-DASCVMRKSA-NSMILESOC(=O)\C=C/C(O)=O.CN(C)CC[C@@H](C1=CC=C(Cl)C=C1)C1=CC=CC=N1What you can answer from here — as of September 12, 2026
Which drugs share a target with Dexchlorpheniramine maleate, and which of those have an active Phase 3 trial?
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