Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Penbraya, Trumenba
Generic Name
Neisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen
DrugBank Accession Number
DB10284
Background

Neisseria meningitidis serogroup B recombinant lp2086 a05 protein variant antigen is a sterile vaccine for intramuscular injection indicated for the active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B. It is contained in the suspension of Trumenba, which is a vaccine is composed of two recombinant lipidated factor H binding protein (fHBP) variants from N. meningitidis serogroup B, one from fHBP subfamily A and one from subfamily B (A05 and B01, respectively).

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Conjugate
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Prevention ofInfection caused by neisseria meningitidis serogroup b•••••••••••••••••••••• ••••••••••
Used in combination to preventInfection caused by neisseria meningitidis serogroup bCombination Product in combination with: Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen (DB10285)•••••••••••••••••••••• ••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
PenbrayaNeisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen (0.06 mg/0.5mL) + Neisseria meningitidis group A capsular polysaccharide tetanus toxoid conjugate antigen (5 ug/0.5mL) + Neisseria meningitidis group C capsular polysaccharide tetanus toxoid conjugate antigen (5 ug/0.5mL) + Neisseria meningitidis group W-135 capsular polysaccharide tetanus toxoid conjugate antigen (5 ug/0.5mL) + Neisseria meningitidis group Y capsular polysaccharide tetanus toxoid conjugate antigen (5 ug/0.5mL) + Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen (0.06 mg/0.5mL)Injection, powder, lyophilized, for suspension; Kit; SuspensionIntramuscularPfizer Laboratories Div Pfizer Inc2023-11-27Not applicableUS flag
TRUMENBANeisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen (60 mcg/0.5mL) + Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen (60 mcg/0.5mL)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2018-02-01Not applicableItaly flag
TrumenbaNeisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen (60 mcg/0.5ml) + Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen (60 mcg/0.5ml)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2021-02-12Not applicableEU flag
TrumenbaNeisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen (60 mcg/0.5ml) + Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen (60 mcg/0.5ml)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2021-02-12Not applicableEU flag
TrumenbaNeisseria meningitidis serogroup B recombinant LP2086 A05 protein variant antigen (60 ug/0.5mL) + Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen (60 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings LLC2014-11-05Not applicableUS flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
583WCD0IZI
CAS number
Not Available

References

General References
Not Available
PubChem Substance
347910470
RxNav
1593127

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedOtherMeningococcal Infections1
4CompletedPreventionMeningococcal Vaccines1
3CompletedPreventionMeningococcal Immunisation (Healthy Volunteers)1
3CompletedPreventionMeningococcal Vaccines1
3RecruitingPreventionSplenectomy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for suspension; kit; suspensionIntramuscular
Injection, suspensionIntramuscular
SuspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at December 01, 2015 20:03 / Updated at June 12, 2020 16:52