Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Prevnar 13, Prevnar 20, Vaxneuvance
Generic Name
Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen
DrugBank Accession Number
DB10286
Background

Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 4 individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). It is contained in the vaccine under the market name Prevnar that contains the saccharides for serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F for intramuscular injection. The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Conjugate
Synonyms
  • Streptococcus pneumoniae serotype 4 capsular antigen diphtheria CRM197 protein conjugate vaccine

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Prevention ofInvasive infection caused by streptococcus pneumoniae serotype 4••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
PREVENAR 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2014-07-08Not applicableItaly flag
PREVENAR 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2017-01-10Not applicableItaly flag
PREVENAR 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2017-01-10Not applicableItaly flag
PREVENAR 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2014-07-08Not applicableItaly flag
PREVENAR 13Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 µg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 µg)Injection, suspensionIntramuscularPfizer Europe Ma Eeig2017-01-10Not applicableItaly flag
Unapproved/Other Products

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
TGJ6YZC4W7
CAS number
Not Available

References

General References
Not Available
PubChem Substance
347910472
RxNav
798228

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
4CompletedPreventionAcute Lymphoblastic Leukemia (ALL)1somestatusstop reasonjust information to hide
4CompletedPreventionAsthma2somestatusstop reasonjust information to hide
4CompletedPreventionBone Marrow Transplant (BMT)1somestatusstop reasonjust information to hide
4CompletedPreventionHepatitis A Virus1somestatusstop reasonjust information to hide
4CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections / Invasive Pneumococcal Disease (IPD) / Meningitis / Pneumonia1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, suspensionIntramuscular
SuspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at December 01, 2015 20:03 / Updated at August 13, 2021 20:47