Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Prevnar 13, Prevnar 20, Vaxneuvance
Generic Name
Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen
DrugBank Accession Number
DB10287
Background

Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 6b individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). It is contained in the vaccine under the market name Prevnar that contains the saccharides for serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F for intramuscular injection. The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Conjugate
Synonyms
  • Streptococcus pneumoniae serotype 6B capsular antigen diphtheria CRM197 protein conjugate vaccine

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
PREVENAR 13/0,5 ML IM ENJEKSIYON ICIN SUS. ICEREN KUL.HAZIR ENJEKTORStreptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 μg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg)SuspensionIntramuscularPFİZER PFE İLAÇLARI A.Ş.2020-08-14Not applicableTurkey flag
PREVENAR 13/0,5 ML IM ENJEKSIYON ICIN SUS. ICEREN KUL.HAZIR ENJEKTOR, 10 ADETStreptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 μg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg)SuspensionIntramuscularPFİZER PFE İLAÇLARI A.Ş.2020-08-14Not applicableTurkey flag
PREVENAR 13/0,5 ML IM ENJEKSIYON ICIN SUS. ICEREN KUL.HAZIR ENJEKTOR, 50 ADETStreptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 μg) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 μg)SuspensionIntramuscularPFİZER İLAÇLARI LTD. ŞTİ.2020-08-14Not applicableTurkey flag
PrevnarStreptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings Llc, a Subsidiary of Pfizer Inc.2000-03-012011-02-28US flag
Prevnar 13Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings LLC2010-03-12Not applicableUS flag
Prevnar 13Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2010-03-12Not applicableUS flag
Prevnar 20Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 11A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 12F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 8 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings LLC2021-08-10Not applicableUS flag
VaxneuvanceStreptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4 ug/0.5mL) + Corynebacterium diphtheriae CRM197 protein (30 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2020-11-18Not applicableUS flag
เพรฟนาร์ 13Streptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2.2 ug/0.5mL)SuspensionIntramuscularบริษัท ไฟเซอร์ (ประเทศไทย) จำกัด2013-07-31Not applicableThailand flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
PREVENAR 0.5 ML ENJEKSIYON ICIN SUSPANSIYON ICEREN KULL.HAZ.ENJEKTOR, 1 ADETStreptococcus pneumoniae type 6B capsular polysaccharide diphtheria CRM197 protein conjugate antigen (4 μg) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 μg) + Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 μg) + Streptococcus pneumoniae type 19F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 μg) + Streptococcus pneumoniae type 23F capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 μg) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 μg) + Streptococcus pneumoniae type 9V capsular polysaccharide diphtheria CRM197 protein conjugate antigen (2 μg)SuspensionIntramuscularPFİZER İLAÇLARI LTD. ŞTİ.2020-08-14Not applicableTurkey flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4M543JVT7G
CAS number
Not Available

References

General References
Not Available
PubChem Substance
347910473
RxNav
798230

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionAcute Lymphoblastic Leukemia (ALL)1
4CompletedPreventionAsthma2
4CompletedPreventionBone Marrow Transplant (BMT)1
4CompletedPreventionHepatitis A Virus1
4CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections / Invasive Pneumococcal Disease (IPD) / Meningitis / Pneumonia1
4CompletedPreventionPneumococcal Infection / Pneumonia / Streptococcus Pneumoniae Infections1
4CompletedTreatmentPain1
4RecruitingTreatmentPrimary Immune Deficiency (PID)1
4Unknown StatusPreventionTransplanted1
3CompletedPreventionChronic Obstructive Pulmonary Disease (COPD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionIntramuscular
Injection, suspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on December 01, 2015 20:03 / Updated on August 13, 2021 20:47