Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names

FluMist Quadrivalent

Generic Name

Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen

DrugBank Accession Number

DB11036

Background

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.

There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.

Type

Biotech

Groups

Approved

Biologic Classification

Vaccines
Attenuated

Synonyms

influenza B virus B/Phuket/3073/2013 antigen

Pharmacology

Indication

Not Available

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Associated Conditions

Flu caused by Influenza

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

Products

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
FLUARIX TETRA	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (15 mcg) + Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated) (15 mcg) + Influenza A virus A/South Australia/34/2019 IVR-197 (H3N2) antigen (formaldehyde inactivated) (15 mcg) + Influenza B virus B/Washington/02/2019 recombinant hemagglutinin antigen (15 mcg)	Suspension	Intramuscular		2015-08-03	2019-06-12
Fluenz Tetra	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 FFU/0.2ml) + Influenza A virus A/Hawaii/66/2019 (H1N1) live (attenuated) antigen (10000000 FFU/0.2ml) + Influenza A virus A/Hong Kong/2671/2019 (H3N2) live (attenuated) antigen (10000000 FFU/0.2ml) + Influenza B virus B/Washington/02/2019 live (attenuated) antigen (10000000 FFU/0.2ml)			Astra Zeneca Ab	2021-02-09	Not applicable
Fluenz Tetra	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 FFU/0.2ml) + Influenza A virus A/Hawaii/66/2019 (H1N1) live (attenuated) antigen (10000000 FFU/0.2ml) + Influenza A virus A/Hong Kong/2671/2019 (H3N2) live (attenuated) antigen (10000000 FFU/0.2ml) + Influenza B virus B/Washington/02/2019 live (attenuated) antigen (10000000 FFU/0.2ml)			Astra Zeneca Ab	2021-02-09	Not applicable
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/New caledonia/71/2014 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Slovenia/2903/2015 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Brisbane/60/2008 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2017-08-25	2017-08-25
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Bolivia/559/2013 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Switzerland/9715293/2013 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Brisbane/60/2008 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2015-08-14	2016-06-30
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Norway/16606/2021 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Victoria/1/2020 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Austria/1359417/2021 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2022-08-08	2023-03-15
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Hawaii/66/2019 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Hong Kong/2671/2019 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Washington/02/2019 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2020-08-10	Not applicable
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Singapore/INFIMH-16-0019/2016 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Slovenia/2903/2015 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Colorado/06/2017 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2018-08-10	2020-06-30
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Tasmania/503/2020 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Victoria/1/2020 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Washington/02/2019 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2021-08-02	Not applicable
FluMist Quadrivalent	Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Kansas/14/2017 (H3N2) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza A virus A/Switzerland/3330/2017 (H1N1) live (attenuated) antigen (10000000 [FFU]/0.2mL) + Influenza B virus B/Colorado/06/2017 live (attenuated) antigen (10000000 [FFU]/0.2mL)	Spray	Nasal	MedImmune, LLC	2019-09-05	2020-06-30

Chemical Identifiers

UNII: 91E648A88W
CAS number: Not Available

References

General References

Not Available

External Links

RxNav: 1657228

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Treatment	Flu caused by Influenza	1
4	Completed	Health Services Research	Influenza, Human / Pneumonia	1
4	Completed	Prevention	Flu caused by Influenza / Healthy Subjects (HS)	1
4	Not Yet Recruiting	Prevention	Influenza, Human	1
3	Active Not Recruiting	Prevention	Seasonal Influenza	1
3	Completed	Prevention	Flu caused by Influenza	3
3	Completed	Prevention	Influenza, Human	1
3	Not Yet Recruiting	Prevention	Healthy Subjects (HS)	1
3	Recruiting	Prevention	Influenza immunization	1
3	Recruiting	Prevention	Seasonal Influenza	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection, suspension	Intramuscular
Spray	Nasal
Suspension	Intramuscular

Prices

Not Available

Patents

Not Available

Properties

State: Not Available
Experimental Properties: Not Available

Drug created at December 01, 2015 20:05 / Updated at June 12, 2020 16:53

Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen

Identification

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties