Hydrogen fluoride

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Hydrogen fluoride is a compound used in dentistry to prevent dental caries.

Brand Names
Oral-B Minute-foam, Perfect Choice One Minute
Generic Name
Hydrogen fluoride
DrugBank Accession Number
DB11072
Background

Hydrogen fluoride (Hydrofluoric acid) is a weak acid that is a precursor to almost all fluorine compounds, including pharmaceuticals such as Fluoxetine (Prozac). It is used as a chemical reagent in several industrial processes such as oil refinery. It is also used as etchant, cleaning agent, and a reagent to dissolve oxides and silicates.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 20.0063
Monoisotopic: 20.006228237
Chemical Formula
FH
Synonyms
  • fluorure d'hydrogène
  • Fluorwasserstoff
  • Hydrofluoric acid
  • Hydrogen fluoride, anhydrous
  • Hydrogenfluorid

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
  • Take separate from meals. Avoid eating or drinking for at least 30 minutes after applying hydrogen fluoride oral dental gel.

Products

Products
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Active Moieties
NameKindUNIICASInChI Key
Fluoride ionionicQ80VPU408O16984-48-8KRHYYFGTRYWZRS-UHFFFAOYSA-M
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Henry Schein Topical Fluoride CreamCream0.62 %OralAbj Custom Packaging1997-08-192001-09-27Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Acidulated Phosphate Fluoride Oral SolutionHydrogen fluoride (.017 %) + Sodium fluoride (.65 %)SolutionDentalPdt Image Inc. Dba Pro Dentec Canada1995-12-311999-07-30Canada flag
All Solutions Acidulated Phosphate Fluoride FoamHydrogen fluoride (0.06 %) + Sodium fluoride (2.59 %)SolutionDentalDentsply Professional2006-04-062008-06-20Canada flag
Butler Protect One Minute Apf Fluoride GelHydrogen fluoride (0.17 %) + Phosphoric acid (1.31 %) + Sodium fluoride (1.23 %)GelTopicalJohn O. Butler Company2004-03-102009-07-09Canada flag
Henry Schein Minute Topical Fluoride GelHydrogen fluoride (0.5 %) + Phosphoric acid (1.1 %) + Sodium fluoride (1.7 %)GelDentalAbj Custom PackagingNot applicableNot applicableCanada flag
Henry Schein Minute Topical Foam FluorideHydrogen fluoride (0.5 %) + Sodium fluoride (1.69 %)AerosolDentalAbj Custom PackagingNot applicableNot applicableCanada flag
Pascal PuffHydrogen fluoride (0.75 %) + Phosphoric acid (1 %) + Sodium fluoride (1.95 %)LiquidTopicalPascal International Corporation1999-05-272000-06-13Canada flag
Pdf Gel 1.24%Hydrogen fluoride (3.5 mg / mL) + Sodium fluoride (1.24 %)GelTopicalLab Bmg Inc.1980-12-311998-08-10Canada flag
Perfect Choice 0.717% Root and Dentin DesensHydrogen fluoride (.14 %) + Sodium fluoride (1.09 %) + Stannous fluoride (.4 %)LiquidDentalChallenge Products Inc.1996-08-282001-07-27Canada flag
Pro-dentx Comfort Dentin DesensitizerHydrogen fluoride (0.045 %) + Sodium fluoride (1.31 %) + Stannous fluoride (0.41 %)LiquidDental; OralPdt Image Inc. Dba Pro Dentec Canada1997-05-122007-10-23Canada flag
Thixotropic Acidulated Phos. Fluor. Top. GelHydrogen fluoride (0.065 %) + Sodium fluoride (2.59 %)GelDentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312003-06-27Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Alpha-ProHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalDental Technologies, Inc.2013-04-01Not applicableUS flag
Alpha-ProHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalDental Technologies, Inc.2013-04-01Not applicableUS flag
Denti-Care Topical Fluoride Foam Bubble GumHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2011-02-09Not applicableUS flag
Denti-Care Topical Fluoride Foam GrapeHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2003-05-01Not applicableUS flag
Denti-Care Topical Fluoride Foam OrangeHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2003-05-01Not applicableUS flag
Denti-Care Topical Fluoride Foam RaspberryHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2011-02-09Not applicableUS flag
Denti-Care Topical Sodium Fluoride StrawberryHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2003-05-01Not applicableUS flag
Oral-B Minute-Foam Orang-A-TangyHydrogen fluoride (2.3 mg/1g) + Sodium fluoride (10 mg/1g)AerosolDentalOral-B Laboratories2000-05-04Not applicableUS flag
Perfect ChoiceHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalYoung Dental Manufacturing Co 1, Llc.2006-08-31Not applicableUS flag
Perfect ChoiceHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalYoung Dental Manufacturing Co 1, Llc.2018-12-22Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as halogen hydrides. These are inorganic compounds in which the heaviest atom bonded to a hydrogen atom is a halogen.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Halogen organides
Sub Class
Halogen hydrides
Direct Parent
Halogen hydrides
Alternative Parents
Inorganic hydrides
Substituents
Halogen hydride / Inorganic hydride
Molecular Framework
Not Available
External Descriptors
hydrogen halide, mononuclear parent hydride (CHEBI:29228)
Affected organisms
Not Available

Chemical Identifiers

UNII
RGL5YE86CZ
CAS number
7664-39-3
InChI Key
KRHYYFGTRYWZRS-UHFFFAOYSA-N
InChI
InChI=1S/FH/h1H
IUPAC Name
hydrogen fluoride
SMILES
F

References

General References
Not Available
KEGG Compound
C16487
PubChem Compound
14917
PubChem Substance
347827885
ChemSpider
14214
RxNav
5496
ChEBI
29228
ChEMBL
CHEMBL1232767
Wikipedia
Hydrofluoric_acid
AHFS Codes
  • 34:00.00 — Dental Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionDental
GelDental
Aerosol, foamDental
CreamOral0.62 %
AerosolDental
LiquidTopical
GelTopical
LiquidDental
DiscTopical
LiquidDental; Oral
Gel
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.15ChemAxon
pKa (Strongest Acidic)3.17ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity1.67 m3·mol-1ChemAxon
Polarizability0.79 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on December 03, 2015 16:51 / Updated on June 12, 2021 01:53