Ensulizole is an ingredient used in sunscreens to absorb UVB radiation. Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths.
- Mechanism
- Curator reviewed · 3 references
Ensulizole strongly absorbs UV-B wavelengths. It offers protection against UV-B-induced cyclobutane pyrimidine dimers. Based on the findings in vitro and in cellulo, ensulizole induces damage on the DNA, causes DNA strand breaks and photosensitizes the formation of oxidized guanines via type I and II photosensitization mechanisms following UV-A or UV-B irradiation. Ensulizole is capable of generating reactive oxygen species, including singlet oxygen upon photoexcitation.
- Primary indication
- Indicated to be used as an UV-B-absorbing molecule in sunscreen formulations.Curator reviewed
- Formula / weight
- C13H10N2O3S · 274.29 g/mol (avg)
- First approval
- Canada, 1998
- Also known as
- phenylbenzimidazole sulfonic acid
- Brand names
Resolves to
UVCJGUGAGLDPAA-UHFFFAOYSA-NSMILESOS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C1=CC=CC=C1What you can answer from here — as of May 03, 2025
Which companies are running trials of Ensulizole, in which indications and phases, and which of those programs are still active?
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