Selenious acid

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Identification

Summary

Selenious acid is an ingredient found in supplements, vitamins, parenteral nutrition, and dandruff shampoo.

Brand Names

Multitrace-5, Multrys

Generic Name

Selenious acid

DrugBank Accession Number

DB11127

Background

Selenious acid is the acid form of sodium selenite, a form of selenium ⁸.

Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties. Selenium is a component of glutathione peroxidase enzyme, which protects cell components from oxidative damage due to peroxides produced during cellular metabolism ¹³.

Selenium (Se) has been demonstrated to prevent cancer in numerous animal models when administered selenium at levels exceeding the nutritional requirements. One study showed efficacy in the prevention of malignancy while utilizing a selenium supplement in humans. The reports from such studies have heightened the interest in additional human selenium supplementation studies to validate the results in larger populations ¹⁵.

Interestingly, selenium is being studied as a potential therapy in the prevention or management of atherosclerosis ¹⁸.

Type

Small Molecule

Groups

Approved, Investigational

Structure

Similar Structures

Weight: Average: 128.97
Monoisotopic: 129.916915758
Chemical Formula: H₂O₃Se

Synonyms

selenige Säure
Selenious acid
Selenous acid

External IDs

UN 3283
UN-3283

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Pharmacology

Indication

Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenious acid in TPN formulas helps to maintain plasma selenium levels and also to maintain endogenous stores to prevent deficiency ¹⁹.

Selenium compounds, such as selenium sulfide, are used topically in anti-dandruff shampoos and in cases of seborrhea ¹³.

For the purpose of brevity, selenite will the focus of discussion, and more information about selenium can be obtained at Selenium.

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Treatment of	Selenium deficiency		••• •••

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Selenium is a component glutathione peroxidase, which protects cells from oxidative damage caused by peroxidases produced during cellular metabolism ⁸.

Selenium is needed to maintain the circulatory system. It also keeps the heart muscle and skin tissue healthy. It may also help in the prevention of cancer due to its stimulation of antioxidant activity and protection of cell membranes ¹³, ³.

Selenious acid preserves vitamin E, which improves the cell's antioxidant defense, and plays an important role in the structure of teeth ⁸.

Prolonged TPN (total parenteral nutrition) support in humans has resulted in selenium deficiency symptoms which include muscle pain and tenderness. The symptoms have been reported to respond to supplementation of TPN solutions with selenium Selenium, ¹⁹.

Pediatric conditions, Keshan disease, and Kwashiorkor have been associated with low dietary intake of selenium. The conditions are endemic to geographical areas marked by low selenium content in the soil. Dietary supplementation with selenium salts has been reported to reduce the incidence of the conditions among affected children ¹⁹.

Mechanism of action

Sodium selenite likely has the same mechanism of action as Selenium.

The most important physiological role of sodium selenite is associated with its presence as an active component of many enzymes and proteins, in addition to its antioxidative role. Selenium has been shown to activate anticancer agents, prevent heart and vascular diseases, exhibit anti-proliferative and anti-inflammatory properties, and to stimulate the immune system ²².

Its anticancer properties may be explained by the oxidation of free sulfhydryl groups. Tumor cells express free sulfhydryl groups (–SH) on the surface of their cell membranes and contribute to uncontrolled cell division. Only those compounds that can oxidize these groups to disulfides (S–S) may inhibit this process. Some organic forms of selenium, including selenocysteine, methylseleninic acid, and Se-methylselenocysteine have been established to be antioxidants. However, their anticancer mechanism is still not well understood ²².

Selenious acid, during an in vitro study, was found to stimulate hemoglobin synthesis in three different malignant erythroleukemia cell lines (MEL) ⁸. It has also been shown to increase the release of interleukin 2 in a dose-dependent manner ⁶. Interleukin-2 is made by a type of T lymphocyte (white blood cell). It increases the growth and activity of other T-lymphocytes and B-lymphocytes and this contributes to the development of the immune system ⁶.

Absorption

The absorption of selenite following oral administration approximately 40-70% of an oral dose, based on studies done in humans ²⁰.

Selenoprotein P, the plasma form of selenium, contains at least 40% of the total selenium in plasma ²⁵. Deletion of the gene for selenoprotein P in mouse models alters the distribution of selenium in body tissues suggesting that selenoprotein P is necessary for selenium transport ⁴.

Volume of distribution

Following oral intake and absorption, selenium from sodium selenite is found in the highest concentrations in the liver and kidneys of humans and animals ²⁰.

In one study, tissue samples taken at autopsy from 46 healthy individuals killed in accidents and from 75 corpses of victims of various diseases to analyze selenium levels and distribution ⁴. The per-weight-unit basis of selenium levels ng/gm in wet in tissues decreased in the following order: kidney (469) > liver > spleen > pancreas > heart > brain > lung > bone > skeletal muscle. The highest proportion of body selenium was found in skeletal muscles (27.5%) ⁴, ²⁴. Significantly less selenium was measured in bones (16%) and blood (10%). In the tissues of cancer corpses, the selenium levels were lower than levels in the control group. The lowest selenium concentrations were measured in alcoholic livers ⁴.

Protein binding

Not Available

Metabolism

Absorbed selenium, from both inorganic sources such as selenite and organic sources including selenomethionine, is metabolized to hydrogen selenide, and subsequently incorporated into essential selenoproteins ²⁰.

In vivo, selenium compounds are generally metabolized to reduced states. For example, quadrivalent selenium (Se+4) in selenite often undergoes reduction to Se−2, metabolized firstly to H2Se and, finally, being methylated to various excretory forms. Selenious acid to oxidize sulfurous acid: H2SeO3 + 2H2SO3 → Se0 + 2H2SO4 + H2O ¹⁰.

Se may also produce reactive oxygen species and, thereby, exert cancer-selective cytotoxicity. Selenodiglutathione (SDG) is a primary Se metabolite conjugated to two glutathione (GSH) moieties. Selenodiglutathione increases intracellular selenium accumulation and is significantly more toxic than selenous acid (H2SeO3). ².

The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium ¹⁰.

Hover over products below to view reaction partners

Selenious acid
- Selenodiglutathione
  - Hydrogen Selenide
- Hydrogen Selenide

Route of elimination

Selenium is eliminated mainly in the urine. However, significant endogenous losses through the feces can also occur ²³. The rate of excretion varies with the chemical form of selenium used in supplementation and the route of administration. Other minor routes of elimination are lungs and skin ¹⁹.

Analysis of 72-hour urine sampling from a study of 48 Norwegian women given a 200 μg supplement of selenium in the form of selenite indicated approximately 50% absorption of selenite ²⁰.

Half-life

30 days in beagle dogs ⁸.

Clearance

Not Available

Adverse Effects

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Toxicity

The toxicity of selenium has been consistently well documented. However, some early studies reported that selenium may be a carcinogen. Nelson et al. (1943) showed that rats fed diets containing Se as seleniferous wheat developed hepatic tumors and low-grade carcinomas in 11 out 53 study animals ¹¹.

Selenium at high doses (15-30 mcg/egg) has been reported to have significant adverse embryological effects on developing chickens. There currently no adequate and well-controlled studies in pregnant women. Selenious acid injections should be used during pregnancy only when the potential benefits justify the potential risk to the growing fetus ²⁰.

The presence of selenium in the placenta and the umbilical cord blood has been reported in humans ²⁰.

Overdosage symptoms with selenious acid include:

Acute Brick red–color gastric mucosa, cerebral edema, coma, death, fulminating peripheral vascular collapse, garlic or sour breath odor, gastrointestinal disturbance, hemolysis, hypersalivation, internal vascular congestion, liver necrosis, muscle spasms, pulmonary edema, and restlessness ²⁰.

Chronic Dental defects, dermatitis, garlic odor of breath and/or sweat, gastrointestinal disorders, hair loss, mental depression, metallic taste, nervousness, nausea, vomiting, weak nails ²⁰.

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abacavir	Abacavir may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Aceclofenac	Aceclofenac may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acetaminophen	Acetaminophen may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acetazolamide	Acetazolamide may increase the excretion rate of Selenious acid which could result in a lower serum level and potentially a reduction in efficacy.

Food Interactions

No interactions found.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Sodium selenite	HIW548RQ3W	10102-18-8	BVTBRVFYZUCAKH-UHFFFAOYSA-L
Sodium selenite pentahydrate	0WV4L961ZV	26970-82-1	TUANAMBRHOLYTH-UHFFFAOYSA-L

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Micro Se	Solution	40 mcg / mL	Intravenous	Sandoz Canada Incorporated	1993-12-31	Not applicable
Selenium	Injection, solution	65.4 ug/1mL	Intravenous	AMERICAN REGENT, INC.	1990-09-30	2021-03-31
Selepen	Solution	40 mcg / mL	Intravenous	Partners Health Care, Inc.	1997-01-16	2008-02-15
Selepen Inj 40mcg/ml USP	Liquid	40 mcg / mL	Intravenous	Lyphomed, Division Of Fujisawa Canada Inc.	1984-12-31	1997-01-30

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Formula-SE	Tablet	30 mcg / tab	Oral	Gesar Ag	1997-09-26	2001-07-02
Selenium Supplement	Capsule	30 mcg / cap	Oral	For Mor International Inc.	2000-03-25	2004-08-11

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
ADDAMEL INFUSION N	Sodium selenite pentahydrate (105 mcg) + Chromic chloride hexahydrate (53.3 mcg) + Cupric chloride dihydrate (3.4 mg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Potassium Iodide (166 mcg) + Sodium fluoride (2.1 mg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg)	Solution, concentrate	Intravenous	FRESENIUS KABI COLOMBIA S.A.S.	2006-11-10	2009-05-08
ADDAMEL N	Sodium selenite (17.3 mcg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (0.1 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (19.8 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1.05 mg/ml)	Injection, solution, concentrate	Intravenous	Fresenius Kabi Italia S.R.L.	2014-07-08	2020-05-12
ADDAMEL N	Sodium selenite (6.9 mcg/mL) + Chromic chloride (5.33 mcg/mL) + Cupric Chloride (0.34 mg/mL) + Ferric chloride (0.54 mg/mL) + Manganese chloride (0.099 mg/mL) + Potassium Iodide (16.6 mcg/mL) + Sodium fluoride (0.21 mg/mL) + Sodium molybdate (4.85 mcg/mL) + Zinc chloride (1.36 mg/mL)	Injection, solution, concentrate	Intravenous	FRESENIUS KABI MALAYSIA SDN. BHD	2020-09-08	2024-02-24
ADDAMEL N FOR INFUSION	Sodium selenite (6.9 mcg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (0.34 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (99 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1.36 mg/ml)	Injection	Intravenous	FRESENIUS KABI (SINGAPORE) PTE LTD	1992-01-31	Not applicable
ADDAVEN CONCENTRATE FOR SOLUTION FOR INFUSION	Sodium selenite (17.29 mcg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (102.3 mcg/ml) + Ferric chloride hexahydrate (540 mcg/ml) + Manganese chloride tetrahydrate (19.79 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium fluoride (210 mcg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1050 mcg/ml)	Solution	Intravenous	FRESENIUS KABI (SINGAPORE) PTE LTD	2017-07-24	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Addamel N	Sodium selenite (3.2 ug/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Manganese chloride tetrahydrate (0.027 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)	Injection, solution	Intravenous	Fresenius Kabi USA, LLC	2013-05-07	2017-03-31
ADDAMEL N 20 AMPUL	Sodium selenite (69 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (3.4 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (990 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL)	Injection, solution	Intravenous	FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.	2019-04-30	Not applicable
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYON	Sodium selenite (173 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (1.02 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (198 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL)	Injection, solution	Intravenous	FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.	2016-09-06	Not applicable
Multitrace-5	Selenious acid (32.7 ug/1mL) + Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL) + Zinc sulfate heptahydrate (4.39 mg/1mL)	Injection, solution	Intravenous	AMERICAN REGENT, INC.	1994-02-17	Not applicable
Multitrace-5	Selenious acid (98 ug/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)	Injection, solution, concentrate	Intravenous	AMERICAN REGENT, INC.	1993-09-14	Not applicable

Chemical Identifiers

UNII: F6A27P4Q4R
CAS number: 7783-00-8
InChI Key: MCAHWIHFGHIESP-UHFFFAOYSA-N
InChI: InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)
IUPAC Name: selenous acid
SMILES: O[Se](O)=O

References

General References

Burk RF, Hill KE: Regulation of Selenium Metabolism and Transport. Annu Rev Nutr. 2015;35:109-34. doi: 10.1146/annurev-nutr-071714-034250. Epub 2015 May 13. [Article]
Tobe T, Ueda K, Aoki A, Okamoto Y, Kojima N, Jinno H: Selenium uptake through cystine transporter mediated by glutathione conjugation. J Toxicol Sci. 2017;42(1):85-91. doi: 10.2131/jts.42.85. [Article]
Combs GF Jr, Noguchi T, Scott ML: Mechanisms of action of selenium and vitamin E in protection of biological membranes. Fed Proc. 1975 Oct;34(11):2090-5. [Article]
Zachara BA, Pawluk H, Bloch-Boguslawska E, Sliwka KM, Korenkiewicz J, Skok Z, Ryc K: Tissue level, distribution, and total body selenium content in healthy and diseased humans in Poland. Arch Environ Health. 2001 Sep-Oct;56(5):461-6. doi: 10.1080/00039890109604483. [Article]
Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [Article]
Zhuang T, Xu H, Hao S, Ren F, Chen X, Pan C, Huang K: Effects of selenium on proliferation, interleukin-2 production and selenoprotein mRNA expression of normal and dexamethasone-treated porcine splenocytes. Res Vet Sci. 2015 Feb;98:59-65. doi: 10.1016/j.rvsc.2014.11.019. Epub 2014 Dec 4. [Article]
Haratake M, Hongoh M, Ono M, Nakayama M: Thiol-dependent membrane transport of selenium through an integral protein of the red blood cell membrane. Inorg Chem. 2009 Aug 17;48(16):7805-11. doi: 10.1021/ic900988j. [Article]
Selenious Acid PubChem [Link]
Selenium (As selenious acid) [Link]
Selenium overview [Link]
EPA Label, Selenious Acid [Link]
High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study [Link]
Selenium, URMC Rochester encyclopedia [Link]
Absorption, distribution, and retention of inhaled selenious acid and selenium metal aerosols in Beagle dogs [Link]
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase [Link]
Distribution of Selenium in Plasma of French Women: Relation to Age and Selenium Status [Link]
Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk [Link]
Selenium in the prevention of atherosclerosis and its underlying mechanisms [Link]
Selenium Injection [Link]
Selenious acid as a source of selenium added for nutritional purposes to food supplements [Link]
Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study [Link]
Application of Sodium Selenite in the Prevention and Treatment of Cancers [Link]
Selenious Acid Injection [Link]
Selenium Overview [Link]
Selenoprotein P [Link]
FDA Approved Drug Products: Selenious Acid Injection for intravenous administration [Link]
AIFA Product Information: Selesyn (sodium selenite pentahydrate) oral solution [Link]

External Links

Human Metabolome Database: HMDB0011119
PubChem Compound: 1091
PubChem Substance: 347827908
ChemSpider: 1060
RxNav: 36344
ChEBI: 26642
ChEMBL: CHEMBL2009089
Wikipedia: Selenous_acid

MSDS

Download (132 KB)

Clinical Trials

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Phase	Status	Purpose	Conditions	Count	Start Date	Why Stopped	100+ additional columns
Unlock 175K+ rows when you subscribe.View sample data
Not Available	Completed	Not Available	Severe Sepsis	1	somestatus	stop reason	just information to hide
4	Completed	Treatment	Acute Abdomen / Critically Ill Patients / Selenium Deficiency / Sepsis / Trace Element Deficiency	1	somestatus	stop reason	just information to hide
4	Completed	Treatment	Peripartum Cardiomyopathy	1	somestatus	stop reason	just information to hide
4	Not Yet Recruiting	Treatment	Manganese Safety in Adults	1	somestatus	stop reason	just information to hide
4	Not Yet Recruiting	Treatment	Manganese Safety in Pediatric Patients	1	somestatus	stop reason	just information to hide

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection	Intravenous	5.33 mcg/ml
Injection, solution	Intravenous drip
Solution	Intravenous	5.33 mcg/ml
Capsule	Oral
Tablet	Oral
Tablet, film coated
Tablet	Oral	30 mcg / tab
Liquid	Oral
Solution	Intravenous
Liquid	Intravenous
Solution	Intravenous	40 mcg / mL
Injection, solution	Intravenous
Injection, solution, concentrate	Intravenous
Solution	Intravenous	0.053 mg/10ml
Injection, solution, concentrate	Intravenous; Parenteral
Injection, solution, concentrate	Parenteral
Solution, concentrate	Intravenous
Injection	Intravenous
Tablet	Oral
Injection, solution, concentrate	Intravenous	10 Mikrogramm/ml
Injection, solution	Intravenous	100 Mikrogramm/2ml
Solution	Oral	100 Mikrogramm/2ml
Injection, solution	Intravenous	50 Mikrogramm/ml
Solution	Oral	500 Mikrogramm/10ml
Injection, solution	Intravenous	65.4 ug/1mL
Capsule	Oral	30 mcg / cap
Liquid	Intravenous	40 mcg / mL
Injection, solution	Parenteral
Kit	Oral
Tablet, chewable	Oral
Powder	Oral

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US11786548	No	2021-07-01	2041-07-01
US11975022	No	2021-07-01	2041-07-01
US11998565	No	2021-07-01	2041-07-01

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	70	MSDS
boiling point (°C)	684.9	MSDS
water solubility	soluble	MSDS
pKa	2.46	MSDS

Predicted Properties

Property	Value	Source
logP	-1.3	Chemaxon
pKa (Strongest Acidic)	1.2	Chemaxon
Physiological Charge	-2	Chemaxon
Hydrogen Acceptor Count	4	Chemaxon
Hydrogen Donor Count	2	Chemaxon
Polar Surface Area	57.53 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	19.69 m³·mol^-1	Chemaxon
Polarizability	5.84 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-001i-0900000000-5e6f6f001b6231ea63b1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-004i-0900000000-616e9f94feac061714a5
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-01q9-0900000000-03e729ba5722b8625b72
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-004i-0900000000-616e9f94feac061714a5
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-03di-0900000000-7aaf9290e6348096595e
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-004i-0900000000-616e9f94feac061714a5

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	121.17459	predicted	DeepCCS 1.0 (2019)
[M+H]+	123.32353	predicted	DeepCCS 1.0 (2019)
[M+Na]+	131.54457	predicted	DeepCCS 1.0 (2019)

Enzymes

Details1. Glutathione peroxidase 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Activator

General Function: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402)
Specific Function: glutathione peroxidase activity
Gene Name: GPX1
Uniprot ID: P07203
Uniprot Name: Glutathione peroxidase 1
Molecular Weight: 22087.94 Da

References

High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study [Link]

Details2. Thioredoxin reductase 1, cytoplasmic

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437)
Specific Function: FAD binding
Gene Name: TXNRD1
Uniprot ID: Q16881
Uniprot Name: Thioredoxin reductase 1, cytoplasmic
Molecular Weight: 70905.58 Da

References

Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [Article]

Transporters

Details1. Selenoprotein P

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Transporter

General Function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis
Specific Function: selenium binding
Gene Name: SELENOP
Uniprot ID: P49908
Uniprot Name: Selenoprotein P
Molecular Weight: 43173.37 Da

References

Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk [Link]

Drug created at December 03, 2015 16:51 / Updated at October 03, 2024 04:54

Selenious acid

Identification

Structure for Selenious acid (DB11127)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Clinical Trial & Rare Diseases Add-on Data Package

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Enzymes

References

References

Transporters

References