Selenious acid

Identification

Summary

Selenious acid is an ingredient found in supplements, vitamins, parenteral nutrition, and dandruff shampoo.

Brand Names

Multitrace-5, Multrys

Generic Name

Selenious acid

DrugBank Accession Number

DB11127

Background

Selenious acid is the acid form of sodium selenite, a form of selenium ⁸.

Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties. Selenium is a component of glutathione peroxidase enzyme, which protects cell components from oxidative damage due to peroxides produced during cellular metabolism ¹³.

Selenium (Se) has been demonstrated to prevent cancer in numerous animal models when administered selenium at levels exceeding the nutritional requirements. One study showed efficacy in the prevention of malignancy while utilizing a selenium supplement in humans. The reports from such studies have heightened the interest in additional human selenium supplementation studies to validate the results in larger populations ¹⁵.

Interestingly, selenium is being studied as a potential therapy in the prevention or management of atherosclerosis ¹⁸.

Type

Small Molecule

Groups

Approved, Investigational

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Selenious acid (DB11127)

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Weight

Average: 128.97
Monoisotopic: 129.916915758

Chemical Formula

H₂O₃Se

Synonyms

• selenige Säure
• Selenious acid
• Selenous acid

External IDs

• UN 3283
• UN-3283

Pharmacology

Indication

Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of selenious acid in TPN formulas helps to maintain plasma selenium levels and also to maintain endogenous stores to prevent deficiency ¹⁹.

Selenium compounds, such as selenium sulfide, are used topically in anti-dandruff shampoos and in cases of seborrhea ¹³.

For the purpose of brevity, selenite will the focus of discussion, and more information about selenium can be obtained at Selenium.

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Associated Conditions

• Selenium Deficiency

Associated Therapies

• Parenteral Nutrition
• Selenium Supplementation

Contraindications & Blackbox Warnings

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Pharmacodynamics

Selenium is a component glutathione peroxidase, which protects cells from oxidative damage caused by peroxidases produced during cellular metabolism ⁸.

Selenium is needed to maintain the circulatory system. It also keeps the heart muscle and skin tissue healthy. It may also help in the prevention of cancer due to its stimulation of antioxidant activity and protection of cell membranes ¹³, ³.

Selenious acid preserves vitamin E, which improves the cell's antioxidant defense, and plays an important role in the structure of teeth ⁸.

Prolonged TPN (total parenteral nutrition) support in humans has resulted in selenium deficiency symptoms which include muscle pain and tenderness. The symptoms have been reported to respond to supplementation of TPN solutions with selenium Selenium, ¹⁹.

Pediatric conditions, Keshan disease, and Kwashiorkor have been associated with low dietary intake of selenium. The conditions are endemic to geographical areas marked by low selenium content in the soil. Dietary supplementation with selenium salts has been reported to reduce the incidence of the conditions among affected children ¹⁹.

Mechanism of action

Sodium selenite likely has the same mechanism of action as Selenium.

The most important physiological role of sodium selenite is associated with its presence as an active component of many enzymes and proteins, in addition to its antioxidative role. Selenium has been shown to activate anticancer agents, prevent heart and vascular diseases, exhibit anti-proliferative and anti-inflammatory properties, and to stimulate the immune system ²².

Its anticancer properties may be explained by the oxidation of free sulfhydryl groups. Tumor cells express free sulfhydryl groups (–SH) on the surface of their cell membranes and contribute to uncontrolled cell division. Only those compounds that can oxidize these groups to disulfides (S–S) may inhibit this process. Some organic forms of selenium, including selenocysteine, methylseleninic acid, and Se-methylselenocysteine have been established to be antioxidants. However, their anticancer mechanism is still not well understood ²².

Selenious acid, during an in vitro study, was found to stimulate hemoglobin synthesis in three different malignant erythroleukemia cell lines (MEL) ⁸. It has also been shown to increase the release of interleukin 2 in a dose-dependent manner ⁶. Interleukin-2 is made by a type of T lymphocyte (white blood cell). It increases the growth and activity of other T-lymphocytes and B-lymphocytes and this contributes to the development of the immune system ⁶.

Absorption

The absorption of selenite following oral administration approximately 40-70% of an oral dose, based on studies done in humans ²⁰.

Selenoprotein P, the plasma form of selenium, contains at least 40% of the total selenium in plasma ²⁵. Deletion of the gene for selenoprotein P in mouse models alters the distribution of selenium in body tissues suggesting that selenoprotein P is necessary for selenium transport ⁴.

Volume of distribution

Following oral intake and absorption, selenium from sodium selenite is found in the highest concentrations in the liver and kidneys of humans and animals ²⁰.

In one study, tissue samples taken at autopsy from 46 healthy individuals killed in accidents and from 75 corpses of victims of various diseases to analyze selenium levels and distribution ⁴. The per-weight-unit basis of selenium levels ng/gm in wet in tissues decreased in the following order: kidney (469) > liver > spleen > pancreas > heart > brain > lung > bone > skeletal muscle. The highest proportion of body selenium was found in skeletal muscles (27.5%) ⁴, ²⁴. Significantly less selenium was measured in bones (16%) and blood (10%). In the tissues of cancer corpses, the selenium levels were lower than levels in the control group. The lowest selenium concentrations were measured in alcoholic livers ⁴.

Protein binding

Not Available

Metabolism

Absorbed selenium, from both inorganic sources such as selenite and organic sources including selenomethionine, is metabolized to hydrogen selenide, and subsequently incorporated into essential selenoproteins ²⁰.

In vivo, selenium compounds are generally metabolized to reduced states. For example, quadrivalent selenium (Se+4) in selenite often undergoes reduction to Se−2, metabolized firstly to H2Se and, finally, being methylated to various excretory forms. Selenious acid to oxidize sulfurous acid: H2SeO3 + 2H2SO3 → Se0 + 2H2SO4 + H2O ¹⁰.

Se may also produce reactive oxygen species and, thereby, exert cancer-selective cytotoxicity. Selenodiglutathione (SDG) is a primary Se metabolite conjugated to two glutathione (GSH) moieties. Selenodiglutathione increases intracellular selenium accumulation and is significantly more toxic than selenous acid (H2SeO3). ².

The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium ¹⁰.

Hover over products below to view reaction partners

• Selenious acid
  • Selenodiglutathione
    • Hydrogen Selenide
  • Hydrogen Selenide
    • Selenophosphate
    • Selenocysteine
      • Se-methylselenocysteine selenoxide
        • Methyl selenic acid
      • Methyl-selenol
    • Methyl-selenol
      • Dimethyl selenide
        • Trimethylselenonium

Route of elimination

Selenium is eliminated mainly in the urine. However, significant endogenous losses through the feces can also occur ²³. The rate of excretion varies with the chemical form of selenium used in supplementation and the route of administration. Other minor routes of elimination are lungs and skin ¹⁹.

Analysis of 72-hour urine sampling from a study of 48 Norwegian women given a 200 μg supplement of selenium in the form of selenite indicated approximately 50% absorption of selenite ²⁰.

Half-life

30 days in beagle dogs ⁸.

Clearance

Not Available

Adverse Effects

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Toxicity

The toxicity of selenium has been consistently well documented. However, some early studies reported that selenium may be a carcinogen. Nelson et al. (1943) showed that rats fed diets containing Se as seleniferous wheat developed hepatic tumors and low-grade carcinomas in 11 out 53 study animals ¹¹.

Selenium at high doses (15-30 mcg/egg) has been reported to have significant adverse embryological effects on developing chickens. There currently no adequate and well-controlled studies in pregnant women. Selenious acid injections should be used during pregnancy only when the potential benefits justify the potential risk to the growing fetus ²⁰.

The presence of selenium in the placenta and the umbilical cord blood has been reported in humans ²⁰.

Overdosage symptoms with selenious acid include:

Acute Brick red–color gastric mucosa, cerebral edema, coma, death, fulminating peripheral vascular collapse, garlic or sour breath odor, gastrointestinal disturbance, hemolysis, hypersalivation, internal vascular congestion, liver necrosis, muscle spasms, pulmonary edema, and restlessness ²⁰.

Chronic Dental defects, dermatitis, garlic odor of breath and/or sweat, gastrointestinal disorders, hair loss, mental depression, metallic taste, nervousness, nausea, vomiting, weak nails ²⁰.

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Abacavir	Abacavir may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Aceclofenac	Aceclofenac may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acetaminophen	Acetaminophen may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acetazolamide	Acetazolamide may increase the excretion rate of Selenious acid which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Aclidinium	Aclidinium may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acrivastine	Acrivastine may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Selenious acid which could result in a higher serum level.

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Food Interactions

No interactions found.

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Sodium selenite	HIW548RQ3W	10102-18-8	BVTBRVFYZUCAKH-UHFFFAOYSA-L
Sodium selenite pentahydrate	0WV4L961ZV	26970-82-1	TUANAMBRHOLYTH-UHFFFAOYSA-L

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Micro Se	Solution	40 mcg / mL	Intravenous	Sandoz Canada Incorporated	1993-12-31	Not applicable
Selenium	Injection, solution	65.4 ug/1mL	Intravenous	AMERICAN REGENT, INC.	1990-09-30	2021-03-31
Selepen	Solution	40 mcg / mL	Intravenous	Partners Health Care, Inc.	1997-01-16	2008-02-15
Selepen Inj 40mcg/ml USP	Liquid	40 mcg / mL	Intravenous	Lyphomed, Division Of Fujisawa Canada Inc.	1984-12-31	1997-01-30

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Formula-SE	Tablet	30 mcg / tab	Oral	Gesar Ag	1997-09-26	2001-07-02
Selenium Supplement	Capsule	30 mcg / cap	Oral	For Mor International Inc.	2000-03-25	2004-08-11

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
ADDAMEL INFUSION N	Sodium selenite pentahydrate (105 mcg) + Chromic chloride hexahydrate (53.3 mcg) + Cupric chloride dihydrate (3.4 mg) + Ferric chloride hexahydrate (5.4 mg) + Manganese chloride tetrahydrate (990 mcg) + Potassium Iodide (166 mcg) + Sodium fluoride (2.1 mg) + Sodium molybdate dihydrate (48.5 mcg) + Zinc chloride (13.6 mg)	Solution, concentrate	Intravenous	FRESENIUS KABI COLOMBIA S.A.S.	2006-11-10	2009-05-08
ADDAMEL N FOR INFUSION	Sodium selenite (6.9 mcg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (0.34 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (99 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1.36 mg/ml)	Injection	Intravenous	FRESENIUS KABI (SINGAPORE) PTE LTD	1992-01-31	Not applicable
ADDAVEN CONCENTRATE FOR SOLUTION FOR INFUSION	Sodium selenite (17.29 mcg/ml) + Chromic chloride hexahydrate (5.33 mcg/ml) + Cupric chloride dihydrate (102.3 mcg/ml) + Ferric chloride hexahydrate (540 mcg/ml) + Manganese chloride tetrahydrate (19.79 mcg/ml) + Potassium Iodide (16.6 mcg/ml) + Sodium fluoride (210 mcg/ml) + Sodium molybdate dihydrate (4.85 mcg/ml) + Zinc chloride (1050 mcg/ml)	Solution	Intravenous	FRESENIUS KABI (SINGAPORE) PTE LTD	2017-07-24	Not applicable
Addaven Konzentrat zur Herstellung einer Infusionslösung	Sodium selenite (17.3 μg/ml) + Chromic chloride hexahydrate (5.33 μg/ml) + Cupric chloride dihydrate (0.1 mg/ml) + Ferric chloride hexahydrate (0.54 mg/ml) + Manganese chloride tetrahydrate (19.8 μg/ml) + Potassium Iodide (16.6 μg/ml) + Sodium fluoride (0.21 mg/ml) + Sodium molybdate dihydrate (4.85 μg/ml) + Zinc chloride (1.05 mg/ml)	Injection, solution, concentrate	Intravenous	Fresenius Kabi Austria Gmb H	2015-03-02	Not applicable
ADDEL JUNIOR Konzentrat zur Herstellung einer Infusionslösung	Sodium selenite (4.381 μg/ml) + Copper gluconate (142.8 μg/ml) + Manganese gluconate (4.052 μg/ml) + Potassium Iodide (1.308 μg/ml) + Zinc gluconate (697 μg/ml)	Injection, solution, concentrate	Intravenous	Laboratoire Aguettant	2017-05-17	Not applicable
Addnutriv	Sodium selenite (79 mcg / 10 mL) + Chromic chloride (10 mcg / 10 mL) + Cupric Chloride (380 mcg / 10 mL) + Ferric chloride (1100 mcg / 10 mL) + Manganese chloride (55 mcg / 10 mL) + Potassium Iodide (130 mcg / 10 mL) + Sodium fluoride (950 mcg / 10 mL) + Sodium molybdate (19 mcg / 10 mL) + Zinc chloride (5000 mcg / 10 mL)	Solution	Intravenous	Fresenius Kabi	2020-12-01	Not applicable
Alkadrenergy Tablets	Sodium selenite (37.5 mcg) + Ascorbic acid (60 mg) + Beta carotene (2500 unit) + Biotin (150 mcg) + Calcium (50 mg) + Choline (100 mg) + Chromic chloride (5 mcg) + Cyanocobalamin (45 mcg) + Folic acid (0.2 mg) + Inositol (25 mg) + Iodine (0.1 mg) + Magnesium (50 mg) + Manganese (0.5 mg) + Molybdenum (3 mcg) + Nicotinamide (40 mg) + Pantothenic acid (15 mg) + Pyridoxine hydrochloride (6.25 mg) + Riboflavin (6.25 mg) + Thiamine (6.25 mg) + Zinc (9 mg) + alpha-Tocopherol acetate (15 unit)	Tablet	Oral	Morter Healthsystem	Not applicable	Not applicable
Avengers Vitamin and Mineral Supplement	Sodium selenite (25 mcg / tab) + Ascorbic acid (25 mg / tab) + Vitamin E (10 unit / tab) + Zinc gluconate (15 mg / tab)	Tablet	Oral	For Mor International Inc.	2000-03-25	2002-06-25
C. Vit-min Formula	Sodium selenite (200 mcg) + Ascorbic acid (100 mg) + Biotin (30 mcg) + Calcium (175 mg) + Cholecalciferol (400 unit) + Choline (30 mg) + Chromium (50 mcg) + Copper (5 mg) + Cyanocobalamin (100 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.600 mg) + Inositol (30 mg) + Magnesium (80 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (50 mg) + Calcium pantothenate (50 mg) + Potassium (40 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (50 mg) + Racemethionine (3 mg) + Riboflavin (50 mg) + Silicon (0.01 mg) + Thiamine (50 mg) + Vanadium (10 mcg) + Vitamin A (5000 unit) + Zinc (40 mg) + alpha-Tocopherol acetate (100 unit)	Tablet	Oral	Nutramed Laboratories Inc.	Not applicable	Not applicable
Children's Chewable Tab	Sodium selenite (2.6 mcg / tab) + Ascorbic acid (33.33 mg / tab) + Beta carotene (333.3 unit / tab) + Biotin (33 mcg / tab) + Chromic chloride (2.2 mcg / tab) + Cyanocobalamin (7.33 mcg / tab) + Folic acid (.1 mg / tab) + Magnesium (23.33 mg / tab) + Manganese sulfate (1.82 mg / tab) + Molybdenum (.7 mcg / tab) + Niacin (.33 mg / tab) + Nicotinamide (2.66 mg / tab) + Calcium pantothenate (5 mg / tab) + Potassium (9.44 mg / tab) + Potassium Iodide (.016 mg / tab) + Pyridoxine hydrochloride (1.66 mg / tab) + Racemethionine (2.66 mg / tab) + Riboflavin (1 mg / tab) + Thiamine mononitrate (1.66 mg / tab) + Vitamin A palmitate (333.3 unit / tab) + Zinc (.95 mg / tab) + alpha-Tocopherol succinate (15 unit / tab)	Tablet	Oral	Nf Formulas Inc.	1988-12-31	2000-06-21

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Addamel N	Sodium selenite (3.2 ug/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Manganese chloride tetrahydrate (0.027 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)	Injection, solution	Intravenous	Fresenius Kabi USA, LLC	2013-05-07	2017-03-31
ADDAMEL N 20 AMPUL	Sodium selenite (69 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (3.4 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (990 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL)	Injection, solution	Intravenous	FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.	2020-08-14	Not applicable
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYON	Sodium selenite (173 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (1.02 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Manganese chloride (198 mcg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL)	Injection, solution	Intravenous	FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.	2020-08-14	Not applicable
Multitrace-5	Selenious acid (98 ug/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)	Injection, solution, concentrate	Intravenous	AMERICAN REGENT, INC.	1993-09-14	Not applicable
Multitrace-5	Selenious acid (98 ug/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)	Injection, solution, concentrate	Intravenous	AMERICAN REGENT, INC.	1993-12-17	Not applicable
Multitrace-5	Selenious acid (32.7 ug/1mL) + Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL) + Zinc sulfate heptahydrate (4.39 mg/1mL)	Injection, solution	Intravenous	AMERICAN REGENT, INC.	1994-02-17	Not applicable
Peditrace	Sodium selenite (2 ug/1mL) + Cupric chloride dihydrate (20 ug/1mL) + Manganese chloride tetrahydrate (1 ug/1mL) + Potassium Iodide (1 ug/1mL) + Sodium fluoride (57 ug/1mL) + Zinc chloride (250 ug/1mL)	Injection, solution	Intravenous	Fresenius Kabi USA, LLC	2013-05-09	2016-08-31
Selenium	Selenious acid (65.4 ug/1mL)	Injection, solution	Intravenous	AMERICAN REGENT, INC.	1990-09-30	2021-03-31
Tricare Prenatal 2-part Daily Prenatal Vitamin System	Sodium selenite (.0325 mg/1) + Ascorbic acid (30 mg/1) + Biotin (.150 mg/1) + Cholecalciferol (400 [iU]/1) + Chromium Cr-51 chloride (.060 mg/1) + Copper gluconate (1 mg/1) + Cyanocobalamin (.125 mg/1) + Doconexent (150 1/1) + Ferric pyrophosphate (4.5 mg/1) + Icosapent (37.5 1/1) + Levomefolic acid (1 mg/1) + Manganese citrate decahydrate (1 mg/1) + Nicotinamide (10 mg/1) + Omega-3 fatty acids (75 1/1) + Calcium pantothenate (5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (.85 mg/1) + Sodium molybdate (.0375 mg/1) + Thiamine mononitrate (1.25 mg/1) + Zinc (7 mg/1) + alpha-Tocopherol succinate (15 [iU]/1)	Kit	Oral	Medecor Pharma, Llc	2016-05-10	Not applicable

Categories

ATC Codes

A12CE02 — Sodium selenite

• A12CE — Selenium
• A12C — OTHER MINERAL SUPPLEMENTS
• A12 — MINERAL SUPPLEMENTS
• A — ALIMENTARY TRACT AND METABOLISM

Drug Categories

• Alimentary Tract and Metabolism
• Diet, Food, and Nutrition
• Drugs that are Mainly Renally Excreted
• Elements
• Food
• Micronutrients
• Mineral Supplements
• Minerals
• Physiological Phenomena
• Replacement Preparations
• Selenium Compounds
• Sodium Compounds
• Trace Elements

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of inorganic compounds known as non-metal selenites. These are inorganic non-metallic compounds containing a selenite as its largest oxoanion.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Other mixed metal/non-metal oxoanionic compounds

Sub Class

Non-metal selenites

Direct Parent

Non-metal selenites

Alternative Parents

Inorganic oxides

Substituents

Inorganic oxide / Non-metal selenite

Molecular Framework

Not Available

External Descriptors

selenium oxoacid (CHEBI:26642) / an anion (SELENITE)

Affected organisms

• Humans and other mammals

Chemical Identifiers

UNII

F6A27P4Q4R

CAS number

7783-00-8

InChI Key

MCAHWIHFGHIESP-UHFFFAOYSA-N

InChI

InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)

IUPAC Name

selenous acid

SMILES

O[Se](O)=O

References

General References

1. Burk RF, Hill KE: Regulation of Selenium Metabolism and Transport. Annu Rev Nutr. 2015;35:109-34. doi: 10.1146/annurev-nutr-071714-034250. Epub 2015 May 13. [Article]
2. Tobe T, Ueda K, Aoki A, Okamoto Y, Kojima N, Jinno H: Selenium uptake through cystine transporter mediated by glutathione conjugation. J Toxicol Sci. 2017;42(1):85-91. doi: 10.2131/jts.42.85. [Article]
3. Combs GF Jr, Noguchi T, Scott ML: Mechanisms of action of selenium and vitamin E in protection of biological membranes. Fed Proc. 1975 Oct;34(11):2090-5. [Article]
4. Zachara BA, Pawluk H, Bloch-Boguslawska E, Sliwka KM, Korenkiewicz J, Skok Z, Ryc K: Tissue level, distribution, and total body selenium content in healthy and diseased humans in Poland. Arch Environ Health. 2001 Sep-Oct;56(5):461-6. doi: 10.1080/00039890109604483. [Article]
5. Ganther HE: Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. [Article]
6. Zhuang T, Xu H, Hao S, Ren F, Chen X, Pan C, Huang K: Effects of selenium on proliferation, interleukin-2 production and selenoprotein mRNA expression of normal and dexamethasone-treated porcine splenocytes. Res Vet Sci. 2015 Feb;98:59-65. doi: 10.1016/j.rvsc.2014.11.019. Epub 2014 Dec 4. [Article]
7. Haratake M, Hongoh M, Ono M, Nakayama M: Thiol-dependent membrane transport of selenium through an integral protein of the red blood cell membrane. Inorg Chem. 2009 Aug 17;48(16):7805-11. doi: 10.1021/ic900988j. [Article]
8. Selenious Acid PubChem [Link]
9. Selenium (As selenious acid) [Link]
10. Selenium overview [Link]
11. EPA Label, Selenious Acid [Link]
12. High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study [Link]
13. Selenium, URMC Rochester encyclopedia [Link]
14. Absorption, distribution, and retention of inhaled selenious acid and selenium metal aerosols in Beagle dogs [Link]
15. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase [Link]
16. Distribution of Selenium in Plasma of French Women: Relation to Age and Selenium Status [Link]
17. Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk [Link]
18. Selenium in the prevention of atherosclerosis and its underlying mechanisms [Link]
19. Selenium Injection [Link]
20. Selenious acid as a source of selenium added for nutritional purposes to food supplements [Link]
21. Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study [Link]
22. Application of Sodium Selenite in the Prevention and Treatment of Cancers [Link]
23. Selenious Acid Injection [Link]
24. Selenium Overview [Link]
25. Selenoprotein P [Link]
26. FDA Approved Drug Products: Selenious Acid Injection for intravenous administration [Link]
27. AIFA Product Information: Selesyn (sodium selenite pentahydrate) oral solution [Link]

External Links

Human Metabolome Database

HMDB0011119

PubChem Compound

1091

PubChem Substance

347827908

ChemSpider

1060

RxNav

36344

ChEBI

26642

ChEMBL

CHEMBL2009089

Wikipedia

Selenous_acid

MSDS

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Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Treatment	Acute Abdomen / Critically Ill Patients / Selenium Deficiency / Sepsis / Trace Element Deficiency	1
4	Completed	Treatment	Peripartum Cardiomyopathy	1
4	Not Yet Recruiting	Treatment	Manganese Safety in Adults	1
4	Not Yet Recruiting	Treatment	Manganese Safety in Pediatric Patients	1
3	Active Not Recruiting	Prevention	Chemotherapy Induced Peripheral Neuropathy (CIPN) / Fallopian Tube Cancer / Ovarian Cancer / Primary Peritoneal Carcinoma / Recurrent Ovarian Carcinoma	1
3	Active Not Recruiting	Treatment	Cardiovascular Disease (CVD)	1
3	Completed	Treatment	Arsenic Exposure / Arsenic Poisoning / Arsenic Toxicity / Arsenical Cancers / Arsenical Keratosis / Arsenical Melanosis / Arsenicosis	1
3	Completed	Treatment	Left Ventricular Dysfunction	1
3	Completed	Treatment	Septic Shock / Severe Sepsis	1
2	Completed	Treatment	Breast Neoplasms / Lymphedema	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection	Intravenous	5.33 mcg/ml
Injection, solution	Intravenous drip
Solution	Intravenous	5.33 mcg/ml
Capsule	Oral
Tablet	Oral
Tablet, film coated
Tablet	Oral	30 mcg / tab
Liquid	Oral
Solution	Intravenous
Liquid	Intravenous
Solution	Intravenous	40 mcg / mL
Injection, solution	Intravenous
Injection, solution, concentrate	Intravenous
Solution	Intravenous	0.053 mg/10ml
Injection, solution, concentrate	Intravenous; Parenteral
Injection, solution, concentrate	Parenteral
Solution, concentrate	Intravenous
Injection	Intravenous
Tablet	Oral
Injection, solution, concentrate	Intravenous
Injection, solution	Intravenous	100 Mikrogramm/2ml
Solution	Oral
Injection, solution	Intravenous	50 Mikrogramm/ml
Injection, solution	Intravenous	65.4 ug/1mL
Capsule	Oral	30 mcg / cap
Liquid	Intravenous	40 mcg / mL
Injection, solution	Parenteral
Kit	Oral
Tablet, chewable	Oral
Powder	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	70	MSDS
boiling point (°C)	684.9	MSDS
water solubility	soluble	MSDS
pKa	2.46	MSDS

Predicted Properties

Property	Value	Source
logP	-1.3	Chemaxon
pKa (Strongest Acidic)	1.2	Chemaxon
Physiological Charge	-2	Chemaxon
Hydrogen Acceptor Count	4	Chemaxon
Hydrogen Donor Count	2	Chemaxon
Polar Surface Area	57.53 Å2	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	19.69 m3·mol-1	Chemaxon
Polarizability	5.84 Å3	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

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Drug created at December 03, 2015 16:51 / Updated at December 01, 2023 08:05