This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Chromium Cr-51
- DrugBank Accession Number
- DB11140
- Background
Chromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,1,2 and in hematology to determine red blood cell volume or mass, study the red blood cell survival time and evaluate blood loss.3,4
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Chromium Cr-51 (DB11140)
- Weight
- Average: 50.9448
Monoisotopic: 50.944771767 - Chemical Formula
- Cr
- Synonyms
- Chromium (51 Cr)
- Chromium Cr 51
- Chromium-51
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
There is evidence that chromium binds to the globin moiety of hemoglobin.3
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Chromium Cr-51 has a physical half-life of 27.7 days.2
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Chromium Cr-51 chloride U4M5Y13FGM 16284-59-6 QSWDMMVNRMROPK-XDETZXHVSA-K Chromium Cr-51 edetate N3Y22O955Z 27849-89-4 YJZDPFHZDKVOTR-HCMAANCNSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Sodium Chromate 51 Solution 1 mCi/5mL Intravenous Anazao Health Corporation 2012-06-19 Not applicable US 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bacmin Chromium Cr-51 chloride (0.1 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Manganese gluconate (5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet, coated Oral Marnel Pharmaceuticals, Llc 2000-04-01 Not applicable US Sodium Chromate 51 Chromium Cr-51 (1 mCi/5mL) Solution Intravenous Anazao Health Corporation 2012-06-19 Not applicable US Tricare Prenatal 2-part Daily Prenatal Vitamin System Chromium Cr-51 chloride (.060 mg/1) + Ascorbic acid (30 mg/1) + Biotin (.150 mg/1) + Cholecalciferol (400 [iU]/1) + Copper gluconate (1 mg/1) + Cyanocobalamin (.125 mg/1) + Doconexent (150 1/1) + Ferric pyrophosphate (4.5 mg/1) + Icosapent (37.5 1/1) + Levomefolic acid (1 mg/1) + Manganese citrate decahydrate (1 mg/1) + Nicotinamide (10 mg/1) + Omega-3 fatty acids (75 1/1) + Calcium pantothenate (5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (.85 mg/1) + Sodium selenite (.0325 mg/1) + Sodium molybdate (.0375 mg/1) + Thiamine mononitrate (1.25 mg/1) + Zinc (7 mg/1) + alpha-Tocopherol succinate (15 [iU]/1) Kit Oral Medecor Pharma, Llc 2016-05-10 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous metal compounds
- Class
- Homogeneous transition metal compounds
- Sub Class
- Not Available
- Direct Parent
- Homogeneous transition metal compounds
- Alternative Parents
- Not Available
- Substituents
- Homogeneous transition metal
- Molecular Framework
- Not Available
- External Descriptors
- chromium atom (CHEBI:50076)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9QAU17N705
- CAS number
- 14392-02-0
- InChI Key
- VYZAMTAEIAYCRO-BJUDXGSMSA-N
- InChI
- InChI=1S/Cr/i1-1
- IUPAC Name
- (51Cr)chromium
- SMILES
- [51Cr]
References
- General References
- Dinet J, Le Cloirec J, Becker S, Salles A, Bohn P: [Discontinuation of Chromium-51 for clinical use: What are the possible alternatives for radiopharmacies and nuclear medicine departments?] Ann Pharm Fr. 2020 Jul;78(4):335-342. doi: 10.1016/j.pharma.2020.01.006. Epub 2020 Jan 23. [Article]
- Authors unspecified: Chromium Cr 51 Edetate . [Article]
- Peters AM, Osman S, Reavy HJ, Chambers B, Deenmamode M, Lewis SM: Erythrocyte radiolabelling: in vitro comparison of chromium, technetium, and indium in undamaged and heat damaged cells. J Clin Pathol. 1986 Jul;39(7):717-21. doi: 10.1136/jcp.39.7.717. [Article]
- Drugs.com Sodium Chromate CR 51 product label [Link]
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral Injection Intravenous 3.7 MBq/ml Solution Intravenous 1 mCi/5mL Kit Oral Tablet, chewable Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0 mg/mL ALOGPS logP -1.3 ALOGPS logP -0.16 Chemaxon logS 1.08 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at December 03, 2015 16:51 / Updated at September 05, 2022 12:50