Manganese gluconate
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Overview
- Description
- An ingredient found in supplements and vitamins.
- Description
- An ingredient found in supplements and vitamins.
- DrugBank ID
- DB11141
- Type
- Small Molecule
- Clinical Trials
- Phase 0
- 0
- Phase 1
- 0
- Phase 2
- 0
- Phase 3
- 0
- Phase 4
- 0
Identification
- Summary
Manganese gluconate is an ingredient found in a variety of supplements and vitamins.
- Generic Name
- Manganese gluconate
- DrugBank Accession Number
- DB11141
- Background
Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. Manganese gluconate is a direct ingredient in food substances as a nutrient supplement. In pharmaceutical preparations it is used as a Manganese cation supplement.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 445.232
Monoisotopic: 445.038999 - Chemical Formula
- C12H22MnO14
- Synonyms
- Manganese D-gluconate
- Manganese gluconate anhydrous
- Manganese(II) gluconate
Pharmacology
- Indication
Manganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of Manganese cation [FDA Label].
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to prevent Trace element deficiency Combination Product in combination with: Sodium fluoride (DB09325), Copper gluconate (DB11246), Zinc gluconate (DB11248), Sodium molybdate (DB14496), Ferrous gluconate (DB14488), Selenious acid (DB11127), Chromic chloride (DB09129), Potassium Iodide (DB06715) •••••••••••• ••••••••• ••••••••••• Used in combination to treat Trace element deficiency Combination Product in combination with: Sodium fluoride (DB09325), Copper gluconate (DB11246), Zinc gluconate (DB11248), Ferrous gluconate (DB14488), Selenious acid (DB11127), Chromic chloride (DB09129), Sodium molybdate (DB14496), Potassium Iodide (DB06715) •••••••••••• ••••••••• ••••••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Manganese gluconate is a salt which dissociates in body fluids to form manganese and gluconic acid. Its pharmacological effects are due to the normal role of Manganese cation in the body.
- Mechanism of action
Acts as a Manganese cation supplement. See Manganese cation for information on its role in the body.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Manganese cation ionic H6EP7W5457 16397-91-4 WAEMQWOKJMHJLA-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Manganese (gluconate) 10 Mg Tablets Tablet 10 mg Oral General Nutrition Canada Inc. 1997-04-18 2006-08-03 Canada Manganese Caps 10mg Capsule 10 mg / cap Oral Twin Laboratories Inc. 1995-12-31 1999-11-10 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ADDEL JUNIOR Konzentrat zur Herstellung einer Infusionslösung Manganese gluconate (4.052 μg/ml) + Copper gluconate (142.8 μg/ml) + Potassium Iodide (1.308 μg/ml) + Sodium selenite (4.381 μg/ml) + Zinc gluconate (697 μg/ml) Injection, solution, concentrate Intravenous Laboratoire Aguettant 2017-05-17 Not applicable Austria ANTIOXIDANT FORMULA 45 FILM TABLET Manganese gluconate (1 mg) + Ascorbic acid (333 mg) + Beta carotene (5000 IU) + Copper gluconate (0.3 mg) + Selenium (0.033 mg) + Vitamin E (133 IU) + Zinc gluconate (5 mg) Tablet, film coated Oral FERROSAN SAĞLIK ÜRÜN VE HİZMETLERİ A.Ş. 1996-07-16 Not applicable Turkey Cal-mag Plus K, Mn and Zn Caplets Manganese gluconate (2.5 mg / tab) + Calcium carbonate (175 mg / tab) + Magnesium oxide (87.5 mg / tab) + Potassium gluconate (5 mg / tab) + Zinc oxide (2.5 mg / tab) Tablet Oral Health Wise Nutrition Inc. 1994-12-31 1999-08-13 Canada Children's Chew Multi & Min Tab Manganese gluconate (.5 mg / tab) + Ascorbic acid (30 mg / tab) + Beta carotene (1250 unit / tab) + Biotin (75 mcg / tab) + Calcium carbonate (100 mg / tab) + Choline bitartrate (5 mg / tab) + Copper gluconate (1 mg / tab) + Cyanocobalamin (5 mcg / tab) + DL-alpha tocopheryl acetate (15 unit / tab) + Ferrous gluconate (2.5 mg / tab) + Iodine (.075 mg / tab) + Magnesium oxide (25 mg / tab) + Nicotinamide (10 mg / tab) + Calcium pantothenate (6.25 mg / tab) + Potassium chloride (.5 mg / tab) + Potassium chloride (5 mg / tab) + Pyridoxine hydrochloride (1.25 mg / tab) + Riboflavin (1.25 mg / tab) + Thiamine hydrochloride (1.25 mg / tab) + Vitamin A palmitate (1250 unit / tab) + Vitamin D (200 unit / tab) + Zinc gluconate (1.25 mg / tab) Tablet Oral Natrol, Inc. 1995-12-31 2001-07-30 Canada Chromease Tab Manganese gluconate (5 mg) + Chromium (15 mcg) + Magnesium oxide (50 mg) + Thiamine hydrochloride (10 mg) + Zinc gluconate (7.5 mg) Tablet Oral Anabolic Laboratories Inc. 1981-12-31 2004-03-15 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bacmin Manganese gluconate (5 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet, coated Oral Marnel Pharmaceuticals, Llc 2000-04-01 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7G09WJ8QIR
- CAS number
- 6485-39-8
- InChI Key
- OXHQNTSSPHKCPB-IYEMJOQQSA-L
- InChI
- InChI=1S/2C6H12O7.Mn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
- IUPAC Name
- manganese(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
- SMILES
- [Mn++].[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O.[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O
References
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Active Not Recruiting Not Available COVID-19, Long Haul / Long Haul COVID / Post-Acute COVID-19 / Post-acute COVID-19 (PACS), or "Long COVID" Syndrome 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral Tablet, coated Oral Tablet Oral Liquid Oral Tablet Oral 10 mg Capsule Oral 10 mg / cap Solution, concentrate Intravenous Tablet, extended release Oral Injection, solution, concentrate Intravenous Capsule Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 36.3 mg/mL ALOGPS logP -2 ALOGPS logP -3.4 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 3.39 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 141.28 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 49.11 m3·mol-1 Chemaxon Polarizability 16.62 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53