Manganese gluconate

Identification

Summary

Manganese gluconate is an ingredient found in a variety of supplements and vitamins.

Generic Name
Manganese gluconate
DrugBank Accession Number
DB11141
Background

Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. Manganese gluconate is a direct ingredient in food substances as a nutrient supplement. In pharmaceutical preparations it is used as a Manganese supplement.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 445.232
Monoisotopic: 445.038999
Chemical Formula
C12H22MnO14
Synonyms
  • Manganese D-gluconate
  • Manganese gluconate anhydrous
  • Manganese(II) gluconate

Pharmacology

Indication

Manganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of Manganese [FDA Label].

Pharmacology
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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Manganese gluconate is a salt which dissociates in body fluids to form manganese and gluconic acid. Its pharmacological effects are due to the normal role of Manganese in the body.

Mechanism of action

Acts as a Manganese supplement. See Manganese for information on its role in the body.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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Active Moieties
NameKindUNIICASInChI Key
ManganeseionicH6EP7W54577439-96-5WAEMQWOKJMHJLA-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ANTIOXIDANT FORMULA 45 FILM TABLETManganese gluconate (1 mg) + Ascorbic acid (333 mg) + Beta carotene (5000 IU) + Copper gluconate (0.3 mg) + Selenium (0.033 mg) + Vitamin E (133 IU) + Zinc gluconate (5 mg)Tablet, film coatedOralFERROSAN SAĞLIK ÜRÜN VE HİZMETLERİ A.Ş.2020-08-14Not applicableTurkey flag
GLUCOGUARDManganese gluconate (0.75 mg) + Ascorbic acid (82.5 mg) + Biotin (50 mcg) + Chromium (200 mcg) + D-alpha-Tocopherol acetate (24.3 IU) + Inositol (5 mg) + Magnesium oxide (12.5 mg) + Pantothenic acid (1.8 mg) + Taurine (25 mg) + Vanadium (5 mcg) + Vitamin A (100 IU)TabletOralVIVA LIFE SCIENCE SDN. BHD.2020-09-08Not applicableMalaysia flag
Gynedyn TabManganese gluconate (200 mg / tab) + Ascorbic acid (100 mg / tab) + Fish liver oil (1000 unit / tab) + Potassium (.15 mg / tab) + Pyridoxine hydrochloride (20 mg / tab) + Riboflavin (10 mg / tab) + Thiamine hydrochloride (10 mg / tab) + alpha-Tocopherol succinate (50 unit / tab)TabletOralNutri Dyn Products Ltd.1976-12-311999-07-19Canada flag
SENSITRACE®Manganese gluconate (445.69 mcg) + Chromic chloride (30.45 mcg) + Copper gluconate (2142.4 mcg) + Ferrous gluconate (7988.2 mcg) + Potassium Iodide (170.06 mcg) + Sodium selenite (153.32 mcg) + Sodium fluoride (2099.5 mcg) + Sodium molybdate (42.93 mcg) + Zinc gluconate (69700 mcg)Solution, concentrateIntravenousLABORATORIO AGUETTANT2018-08-13Not applicableColombia flag
Zymain TabManganese gluconate (18 mg) + Calcium ascorbate (100 mg) + Manganese sulfate (56 mg) + Zinc (10 mg)TabletOralAnabolic Laboratories Inc.1985-12-312004-03-15Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BacminManganese gluconate (5 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)Tablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7G09WJ8QIR
CAS number
6485-39-8
InChI Key
OXHQNTSSPHKCPB-IYEMJOQQSA-L
InChI
InChI=1S/2C6H12O7.Mn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
IUPAC Name
manganese(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
SMILES
[Mn++].[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O.[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O

References

General References
Not Available
PubChem Substance
347911132
ChemSpider
21514
RxNav
52403
FDA label
Download (124 KB)
MSDS
Download (50.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solution, concentrateIntravenous
Tablet, film coatedOral
Tablet, coatedOral
TabletOral
Solution, concentrateIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility36.3 mg/mLALOGPS
logP-2ALOGPS
logP-3.4ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)3.39ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area141.28 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity49.11 m3·mol-1ChemAxon
Polarizability16.62 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 16:51 / Updated on June 12, 2020 16:53