Identification
- Summary
Manganese gluconate is an ingredient found in a variety of supplements and vitamins.
- Generic Name
- Manganese gluconate
- DrugBank Accession Number
- DB11141
- Background
Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. Manganese gluconate is a direct ingredient in food substances as a nutrient supplement. In pharmaceutical preparations it is used as a Manganese supplement.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Manganese gluconate (DB11141)
- Weight
- Average: 445.232
Monoisotopic: 445.038999 - Chemical Formula
- C12H22MnO14
- Synonyms
- Manganese D-gluconate
- Manganese gluconate anhydrous
- Manganese(II) gluconate
Pharmacology
- Indication
Manganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of Manganese [FDA Label].
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- Associated Therapies
- Contraindications & Blackbox Warnings
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Manganese gluconate is a salt which dissociates in body fluids to form manganese and gluconic acid. Its pharmacological effects are due to the normal role of Manganese in the body.
- Mechanism of action
Acts as a Manganese supplement. See Manganese for information on its role in the body.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Manganese ionic H6EP7W5457 7439-96-5 WAEMQWOKJMHJLA-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Manganese (gluconate) 10 Mg Tablets Tablet 10 mg Oral General Nutrition Canada Inc. 1997-04-18 2006-08-03 Canada 
Manganese Caps 10mg Capsule 10 mg / cap Oral Twin Laboratories Inc. 1995-12-31 1999-11-10 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ADDEL JUNIOR Konzentrat zur Herstellung einer Infusionslösung Manganese gluconate (4.052 μg/ml) + Copper gluconate (142.8 μg/ml) + Potassium Iodide (1.308 μg/ml) + Sodium selenite (4.381 μg/ml) + Zinc gluconate (697 μg/ml) Injection, solution, concentrate Intravenous Laboratoire Aguettant 2017-05-17 Not applicable Austria 
ANTIOXIDANT FORMULA 45 FILM TABLET Manganese gluconate (1 mg) + Ascorbic acid (333 mg) + Beta carotene (5000 IU) + Copper gluconate (0.3 mg) + Selenium (0.033 mg) + Vitamin E (133 IU) + Zinc gluconate (5 mg) Tablet, film coated Oral FERROSAN SAĞLIK ÜRÜN VE HİZMETLERİ A.Ş. 2020-08-14 Not applicable Turkey 
Cal-mag Plus K, Mn and Zn Caplets Manganese gluconate (2.5 mg / tab) + Calcium carbonate (175 mg / tab) + Magnesium oxide (87.5 mg / tab) + Potassium gluconate (5 mg / tab) + Zinc oxide (2.5 mg / tab) Tablet Oral Health Wise Nutrition Inc. 1994-12-31 1999-08-13 Canada Children's Chew Multi & Min Tab Manganese gluconate (.5 mg / tab) + Ascorbic acid (30 mg / tab) + Beta carotene (1250 unit / tab) + Biotin (75 mcg / tab) + Calcium carbonate (100 mg / tab) + Choline bitartrate (5 mg / tab) + Copper gluconate (1 mg / tab) + Cyanocobalamin (5 mcg / tab) + DL-alpha tocopheryl acetate (15 unit / tab) + Ferrous gluconate (2.5 mg / tab) + Iodine (.075 mg / tab) + Magnesium oxide (25 mg / tab) + Nicotinamide (10 mg / tab) + Calcium pantothenate (6.25 mg / tab) + Potassium chloride (.5 mg / tab) + Potassium chloride (5 mg / tab) + Pyridoxine hydrochloride (1.25 mg / tab) + Riboflavin (1.25 mg / tab) + Thiamine hydrochloride (1.25 mg / tab) + Vitamin A palmitate (1250 unit / tab) + Vitamin D (200 unit / tab) + Zinc gluconate (1.25 mg / tab) Tablet Oral Natrol, Inc. 1995-12-31 2001-07-30 Canada Chromease Tab Manganese gluconate (5 mg) + Chromium (15 mcg) + Magnesium oxide (50 mg) + Thiamine hydrochloride (10 mg) + Zinc gluconate (7.5 mg) Tablet Oral Anabolic Laboratories Inc. 1981-12-31 2004-03-15 Canada E 400iu W Selenium 100mcg Manganese gluconate (10 mg / tab) + Ascorbic acid (100 mg / tab) + Selenium (100 mcg / tab) + Vitamin E (400 unit / tab) Tablet Oral Gahler Enterprises Ltd. 1987-12-31 2000-08-01 Canada GLUCOGUARD Manganese gluconate (0.75 mg) + Ascorbic acid (82.5 mg) + Biotin (50 mcg) + Chromium (200 mcg) + D-alpha-Tocopherol acetate (24.3 IU) + Inositol (5 mg) + Magnesium oxide (12.5 mg) + Pantothenic acid (1.8 mg) + Taurine (25 mg) + Vanadium (5 mcg) + Vitamin A (100 IU) Tablet Oral VIVA LIFE SCIENCE SDN. BHD. 2020-09-08 Not applicable Malaysia 
Gtf-vitamin-minerals & Pancreatin Tab Manganese gluconate (2 mg / tab) + Chromium (45 mcg / tab) + Niacin (5 mg / tab) + Pancrelipase amylase (10000 unit / tab) + Pancrelipase lipase (800 unit / tab) + Pancrelipase protease (10000 unit / tab) + Thiamine hydrochloride (100 mg / tab) + Zinc gluconate (10 mg / tab) Tablet Oral Metagenics, Inc. 1989-12-31 1999-08-12 Canada Gynedyn Tab Manganese gluconate (200 mg / tab) + Ascorbic acid (100 mg / tab) + Fish liver oil (1000 unit / tab) + Potassium Iodide (.15 mg / tab) + Pyridoxine hydrochloride (20 mg / tab) + Riboflavin (10 mg / tab) + Thiamine hydrochloride (10 mg / tab) + alpha-Tocopherol succinate (50 unit / tab) Tablet Oral Nutri Dyn Products Ltd. 1976-12-31 1999-07-19 Canada Iron Plus Manganese, B12, Folic Acid & C Manganese gluconate (2 mg) + Ascorbic acid (50 mg) + Cyanocobalamin (10 mcg) + Ferrous fumarate (60 mg) + Folic acid (.1 mg) Tablet Oral Natural Factors Nutritional Products Ltd. 1988-12-31 2005-08-15 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bacmin Manganese gluconate (5 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1) Tablet, coated Oral Marnel Pharmaceuticals, Llc 2000-04-01 Not applicable US 
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7G09WJ8QIR
- CAS number
- 6485-39-8
- InChI Key
- OXHQNTSSPHKCPB-IYEMJOQQSA-L
- InChI
- InChI=1S/2C6H12O7.Mn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
- IUPAC Name
- manganese(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
- SMILES
- [Mn++].[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O.[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O
References
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral Tablet, coated Oral Tablet Oral Liquid Oral Tablet Oral 10 mg Capsule Oral 10 mg / cap Solution, concentrate Intravenous Tablet, extended release Oral Injection, solution, concentrate Intravenous Capsule Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 36.3 mg/mL ALOGPS logP -2 ALOGPS logP -3.4 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 3.39 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 141.28 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 49.11 m3·mol-1 Chemaxon Polarizability 16.62 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53