Manganese gluconate

Identification

Summary

Manganese gluconate is an ingredient found in a variety of supplements and vitamins.

Generic Name

Manganese gluconate

DrugBank Accession Number

DB11141

Background

Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. Manganese gluconate is a direct ingredient in food substances as a nutrient supplement. In pharmaceutical preparations it is used as a Manganese supplement.

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 445.232
Monoisotopic: 445.038999
Chemical Formula: C₁₂H₂₂MnO₁₄

Synonyms

Manganese D-gluconate
Manganese gluconate anhydrous
Manganese(II) gluconate

Pharmacology

Indication

Manganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of Manganese [FDA Label].

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Associated Conditions

Trace Element Deficiency

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Manganese gluconate is a salt which dissociates in body fluids to form manganese and gluconic acid. Its pharmacological effects are due to the normal role of Manganese in the body.

Mechanism of action

Acts as a Manganese supplement. See Manganese for information on its role in the body.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: No interactions found.

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Manganese	ionic	H6EP7W5457	7439-96-5	WAEMQWOKJMHJLA-UHFFFAOYSA-N

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Manganese (gluconate) 10 Mg Tablets	Tablet	10 mg	Oral	General Nutrition Canada Inc.	1997-04-18	2006-08-03
Manganese Caps 10mg	Capsule	10 mg / cap	Oral	Twin Laboratories Inc.	1995-12-31	1999-11-10

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
ADDEL JUNIOR Konzentrat zur Herstellung einer Infusionslösung	Manganese gluconate (4.052 μg/ml) + Copper gluconate (142.8 μg/ml) + Potassium Iodide (1.308 μg/ml) + Sodium selenite (4.381 μg/ml) + Zinc gluconate (697 μg/ml)	Injection, solution, concentrate	Intravenous	Laboratoire Aguettant	2017-05-17	Not applicable
ANTIOXIDANT FORMULA 45 FILM TABLET	Manganese gluconate (1 mg) + Ascorbic acid (333 mg) + Beta carotene (5000 IU) + Copper gluconate (0.3 mg) + Selenium (0.033 mg) + Vitamin E (133 IU) + Zinc gluconate (5 mg)	Tablet, film coated	Oral	FERROSAN SAĞLIK ÜRÜN VE HİZMETLERİ A.Ş.	2020-08-14	Not applicable
Cal-mag Plus K, Mn and Zn Caplets	Manganese gluconate (2.5 mg / tab) + Calcium carbonate (175 mg / tab) + Magnesium oxide (87.5 mg / tab) + Potassium gluconate (5 mg / tab) + Zinc oxide (2.5 mg / tab)	Tablet	Oral	Health Wise Nutrition Inc.	1994-12-31	1999-08-13
Children's Chew Multi & Min Tab	Manganese gluconate (.5 mg / tab) + Ascorbic acid (30 mg / tab) + Beta carotene (1250 unit / tab) + Biotin (75 mcg / tab) + Calcium carbonate (100 mg / tab) + Choline bitartrate (5 mg / tab) + Copper gluconate (1 mg / tab) + Cyanocobalamin (5 mcg / tab) + DL-alpha tocopheryl acetate (15 unit / tab) + Ferrous gluconate (2.5 mg / tab) + Iodine (.075 mg / tab) + Magnesium oxide (25 mg / tab) + Nicotinamide (10 mg / tab) + Calcium pantothenate (6.25 mg / tab) + Potassium chloride (.5 mg / tab) + Potassium chloride (5 mg / tab) + Pyridoxine hydrochloride (1.25 mg / tab) + Riboflavin (1.25 mg / tab) + Thiamine hydrochloride (1.25 mg / tab) + Vitamin A palmitate (1250 unit / tab) + Vitamin D (200 unit / tab) + Zinc gluconate (1.25 mg / tab)	Tablet	Oral	Natrol, Inc.	1995-12-31	2001-07-30
Chromease Tab	Manganese gluconate (5 mg) + Chromium (15 mcg) + Magnesium oxide (50 mg) + Thiamine hydrochloride (10 mg) + Zinc gluconate (7.5 mg)	Tablet	Oral	Anabolic Laboratories Inc.	1981-12-31	2004-03-15
E 400iu W Selenium 100mcg	Manganese gluconate (10 mg / tab) + Ascorbic acid (100 mg / tab) + Selenium (100 mcg / tab) + Vitamin E (400 unit / tab)	Tablet	Oral	Gahler Enterprises Ltd.	1987-12-31	2000-08-01
GLUCOGUARD	Manganese gluconate (0.75 mg) + Ascorbic acid (82.5 mg) + Biotin (50 mcg) + Chromium (200 mcg) + D-alpha-Tocopherol acetate (24.3 IU) + Inositol (5 mg) + Magnesium oxide (12.5 mg) + Pantothenic acid (1.8 mg) + Taurine (25 mg) + Vanadium (5 mcg) + Vitamin A (100 IU)	Tablet	Oral	VIVA LIFE SCIENCE SDN. BHD.	2020-09-08	Not applicable
Gtf-vitamin-minerals & Pancreatin Tab	Manganese gluconate (2 mg / tab) + Chromium (45 mcg / tab) + Niacin (5 mg / tab) + Pancrelipase amylase (10000 unit / tab) + Pancrelipase lipase (800 unit / tab) + Pancrelipase protease (10000 unit / tab) + Thiamine hydrochloride (100 mg / tab) + Zinc gluconate (10 mg / tab)	Tablet	Oral	Metagenics, Inc.	1989-12-31	1999-08-12
Gynedyn Tab	Manganese gluconate (200 mg / tab) + Ascorbic acid (100 mg / tab) + Fish liver oil (1000 unit / tab) + Potassium Iodide (.15 mg / tab) + Pyridoxine hydrochloride (20 mg / tab) + Riboflavin (10 mg / tab) + Thiamine hydrochloride (10 mg / tab) + alpha-Tocopherol succinate (50 unit / tab)	Tablet	Oral	Nutri Dyn Products Ltd.	1976-12-31	1999-07-19
Iron Plus Manganese, B12, Folic Acid & C	Manganese gluconate (2 mg) + Ascorbic acid (50 mg) + Cyanocobalamin (10 mcg) + Ferrous fumarate (60 mg) + Folic acid (.1 mg)	Tablet	Oral	Natural Factors Nutritional Products Ltd.	1988-12-31	2005-08-15

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Bacmin	Manganese gluconate (5 mg/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (50 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Tablet, coated	Oral	Marnel Pharmaceuticals, Llc	2000-04-01	Not applicable

Chemical Identifiers

UNII: 7G09WJ8QIR
CAS number: 6485-39-8
InChI Key: OXHQNTSSPHKCPB-IYEMJOQQSA-L
InChI: InChI=1S/2C6H12O7.Mn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
IUPAC Name: manganese(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
SMILES: [Mn++].[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O.[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C([O-])=O

References

General References

Not Available

External Links

PubChem Substance: 347911132
ChemSpider: 21514
RxNav: 52403

FDA label

Download (124 KB)

MSDS

Download (50.2 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, film coated	Oral
Tablet, coated	Oral
Tablet	Oral
Liquid	Oral
Tablet	Oral	10 mg
Capsule	Oral	10 mg / cap
Solution, concentrate	Intravenous
Tablet, extended release	Oral
Injection, solution, concentrate	Intravenous
Capsule	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	36.3 mg/mL	ALOGPS
logP	-2	ALOGPS
logP	-3.4	Chemaxon
logS	-1.1	ALOGPS
pKa (Strongest Acidic)	3.39	Chemaxon
pKa (Strongest Basic)	-3	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	7	Chemaxon
Hydrogen Donor Count	5	Chemaxon
Polar Surface Area	141.28 Å²	Chemaxon
Rotatable Bond Count	10	Chemaxon
Refractivity	49.11 m³·mol^-1	Chemaxon
Polarizability	16.62 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53

Manganese gluconate

Identification

Structure for Manganese gluconate (DB11141)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra