Cobamamide

DB11191ApprovedNutraceuticalSmall molecule

Cobamamide is an ingredient found in a variety of supplements and vitamins. Cobamamide is one of the active forms of vitamin B12 that is also known as adenosylcobalamin or dibencozide.

Mechanism: Pharmacologically active on Methylmalonyl-CoA mutase, mitochondrial
Curator reviewed
Formula / weight: C₇₂H₁₀₀CoN₁₈O₁₇P · 1579.5818 g/mol (avg)
First approval: Canada, 1991 · United States, 2015
Also known as: Adenosylcob(III)alamin · Adenosylcobalamin · Coenzyme B-12 · Coenzyme B12 · Vitamin B12 coenzyme
Code names: LM 176
Brand names: EnBrace HR
EnLyte

Resolves to

Compound

UNIIF0R1QK73KBCAS13870-90-1ChEMBLCHEMBL3833359ChEBI18408KEGGD00042

Clinical / RWD

RxNorm21373ATCB03BA04

Structure

InChIKeyZIHHMGTYZOSFRC-OUCXYWSSSA-LSMILES

[C@H]1(C[Co-3]2345[N+]6=C7C(C)=C8N2[C@]([H])([C@H](CC(=O)N)[C@]8(CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@@H]2[C@@H](CO)O[C@H](N8C=[N+]3C3=CC(C)=C(C)C=C83)[C@@H]2O)C)[C@@]2(C)[C@@](CC(=O)N)([C@H](CCC(=O)N)C(C(C)=C3[N+]4=C(C=C6C([C@@H]7CCC(=O)N)(C)C)[C@@H](CCC(=O)N)[C@@]3(CC(=O)N)C)=[N+]52)C)O[C@@H](N2C3=C(N=C2)C(=NC=N3)N)[C@H](O)[C@@H]1O

Targets

P22033MMUT

What you can answer from here — as of July 06, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3Structured indicationsCondition, population, route and combination as fields, not prose

29Marketed productsAcross 5 countries and 12 labellers

1ATC codeIncluding every combination product, plus 9 drug categories

15+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cobamamide, and which of those have an active Phase 3 trial?

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