Aluminum zirconium octachlorohydrex gly

Identification

Summary

Aluminum zirconium octachlorohydrex gly is an antiperspirant used to reduce sweating.

Generic Name
Aluminum zirconium octachlorohydrex gly
DrugBank Accession Number
DB11200
Background

Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent 8, 9. It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants 11.

Interestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms 2.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 263.74
Monoisotopic: 261.89768
Chemical Formula
C2H8AlClNO4Zr
Synonyms
  • Aluminium zirconium octachlorohydrex gly
  • Aluminium zirconium octachlorohydrex glycine complex
  • Aluminum zirconium octachlorohydrex gly
  • Aluminum zirconium octachlorohydrex glycine complex

Pharmacology

Indication

Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, and indicated for use in hyperhidrosis 12.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Reduces perspiration and body odor 8.

Mechanism of action

Aluminium salts in antiperspirants, such as chlorohydrates, form insoluble plugs within sweat ducts to temporarily prevent sweat reaching the surface of the skin 14, 5, 6, 8.

TargetActionsOrganism
ASweat ducts
antagonist
Humans
Absorption

A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminum-26 was performed. After repeated exposure for 6 days to aluminum chlorohydrate 21 % (about 13 mg of aluminium) to each axilla under occlusive dressing in two volunteers (one man and a woman), on skin previously tape stripped twice, blood and urine samples were obtained. Aluminium was detected in the blood 6 hours after the primary application and remained detectable for 15 days therafter. The results of this study estimate that the proportion of aluminium is absorbed averaged 0.012%. The shortcomings of this study are that it was not done in accordance with good practice (GCP) and it was performed using only 2 volunteers 7.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

The EU has published a statement of caution that antiperspirant should not be applied to damaged or irritated skin, yet it is common to shave the underarm area before applying antiperspirant 14.

The possible health risks of aluminum containing antiperspirant use are not well studied. Although it has been suggested that deodorant and/or antiperspirant use is associated with incidence or age of breast cancer diagnosis 3, a causal relationship between aluminium product use and breast cancer has not been established 2, 4.

The oral toxicity of aluminium compounds for which data are available (bromide, nitrate, chloride and sulfate) is moderate to low, with LD50 values in the range of 162 to 750 mg Al/kg in rats, and from 164 to 980 mg Al/kg in mice, depending on the type of aluminium compound studied 14.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Aluminum cationionic3XHB1D032B22537-23-1REDXJYDRNCIFBQ-UHFFFAOYSA-N
Chloride ionionicQ32ZN4869816887-00-6VEXZGXHMUGYJMC-UHFFFAOYSA-M
AluminiumunknownCPD4NFA9037429-90-5XAGFODPZIPBFFR-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
24 Hour High Performance AntiperspirantStick18.6 mL/100mLTopicalAramis Inc.1984-04-01Not applicableUS flag
5 DayLiquid20 g/100mLTopicalNumark Brands, Inc1937-04-10Not applicableUS flag
Active Antiperspirant and Deodorant for MenCream17.8 g/100gTopicalHarrison Specialty Co., Inc.2011-04-092014-03-10US flag
Adidas 24H Anti Perspirant Deep Energy 2.8Stick12.6 g/79gTopicalCoty Canada Inc.2012-10-01Not applicableUS flag
Adidas 24H Anti Perspirant Dynamic Pulse 2.8Stick12.6 g/79gTopicalCoty Canada Inc.2012-10-01Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DELTA RON 2019 AMENITY With Colgate Cavity ProtectionAluminum zirconium octachlorohydrex gly (15.2 g/100g) + Sodium fluorophosphate (7.6 mg/1g)KitDental; TopicalBuzz Export Services Pty., Ltd.2019-04-01Not applicableUS flag
Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAINAluminum zirconium octachlorohydrex gly (8 mg/1) + Aluminum sesquichlorohydrate (1 mg/1)LiquidTopicalLaboratorios Genesse Sl2016-11-192017-12-31US flag
Lactovit DEODORANT ROLL-ON MEN INVISIBLEAluminum zirconium octachlorohydrex gly (5.28 mg/1) + Aluminum sesquichlorohydrate (0.8 mg/1)LiquidTopicalLaboratorios Genesse Sl2017-04-062017-12-31US flag
Ron 2Aluminum zirconium octachlorohydrex gly (15.2 g/100g) + Sodium fluorophosphate (7.6 mg/1g)KitDental; TopicalBuzz Export Services Pty., Ltd.2015-03-30Not applicableUS flag
Secret Fresh For You Luxe LavenderAluminum zirconium octachlorohydrex gly (18 g/100g) + Aluminum zirconium octachlorohydrex gly (19.2 g/100g)KitTopicalThe Procter & Gamble Manufacturing Company2019-05-012023-03-01US flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
P9D3YP29MY
CAS number
174514-58-0
InChI Key
WYANSMZYIOPJFV-UHFFFAOYSA-L
InChI
InChI=1S/C2H5NO2.Al.ClH.2H2O.Zr/c3-1-2(4)5;;;;;/h1,3H2,(H,4,5);;1H;2*1H2;/q;+3;;;;+4/p-2
IUPAC Name
zirconium(4+) aluminium(3+) 2-aminoacetate dihydrate chloride
SMILES
O.O.[Al+3].[Cl-].[Zr+4].NCC([O-])=O

References

General References
  1. Reynolds K, Darrigrand A, Roberts D, Knapik J, Pollard J, Duplantis K, Jones B: Effects of an antiperspirant with emollients on foot-sweat accumulation and blister formation while walking in the heat. J Am Acad Dermatol. 1995 Oct;33(4):626-30. [Article]
  2. Urban J, Fergus DJ, Savage AM, Ehlers M, Menninger HL, Dunn RR, Horvath JE: The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ. 2016 Feb 2;4:e1605. doi: 10.7717/peerj.1605. eCollection 2016. [Article]
  3. Darbre PD: Aluminium, antiperspirants and breast cancer. J Inorg Biochem. 2005 Sep;99(9):1912-9. doi: 10.1016/j.jinorgbio.2005.06.001. [Article]
  4. Allam MF: Breast Cancer and Deodorants/Antiperspirants: a Systematic Review. Cent Eur J Public Health. 2016 Sep;24(3):245-247. doi: 10.21101/cejph.a4475. [Article]
  5. ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [Link]
  6. Aluminum zirconium pentachlorohydrex Gly [Link]
  7. Product Assessment Against Criteria: Antiperspirants [Link]
  8. LABEL: SECRET COOL WATERLILY CLEAR- aluminum zirconium octachlorohydrex gly gel [Link]
  9. SECRET ACTIVE COOL INVISIBLE- aluminum zirconium tetrachlorohydrex gly stick [Link]
  10. Household Product Database, NIH [Link]
  11. FDA CFR - Code of Federal Regulations Title 21, PART 350: ANTIPERSPIRANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE [Link]
  12. Health Canada Document : Chemical Substance - Aluminum zirconium octachlorohydrex glycine [Link]
  13. Breast Cancer Organization, UK [Link]
  14. Scientific Committee on Consumer Safety SCCS [File]
  15. ZIRKONAL® L435G [File]
PubChem Substance
347911153
ChemSpider
32698594
RxNav
1306096

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Unknown StatusTreatmentGastritis, Gastric Ulcer, and Duodenal Ulcer1
3CompletedTreatmentMalaria1
2CompletedTreatmentCystic Fibrosis (CF)1
2Not Yet RecruitingTreatmentCell Carcinoma1
1CompletedTreatmentLeukemias1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
StickTopical18.6 mL/100mL
LiquidTopical20 g/100mL
StickTopical12.6 g/79g
StickTopical14.2 g/79g
StickTopical18 mg/100g
StickTopical16 g/57g
StickTopical10.24 g/64g
StickTopical11.39 g/64g
LiquidTopical15 g/100mL
StickTopical6.02 g/70g
StickTopical186 mg/1mL
GelTopical20 g/100g
StickTopical17.8 g/100g
GelTopical10.08 g/63g
Aerosol, sprayTopical16 g/100g
StickTopical70 g/100g
StickTopical10.146 g/57g
CreamTopical17 g/100g
GelTopical16.15 g/85g
AerosolTopical19 g/100g
LiquidTopical.2 g/1mL
SolutionTopical0.3 g/100mL
GelTopical0.3 mL/100mL
SolutionTopical0.3 g/100g
StickTopical7.8 g/100g
LotionTopical16 g/100g
LotionTopical.165 g/1g
LiquidTopical18 mg/1mL
StickTopical18.6 g/100g
StickTopical11.65 g/64g
StickTopical20 g/48g
StickTopical18.5 g/100g
StickTopical10 g/100g
StickTopical19.2 g/100g
StickTopical15.2 g/100g
StickTopical182 mg/1g
StickTopical19.0 g/100g
StickTopical20 g/100g
PasteTopical150 mg/1g
Kit; pasteTopical150 mg/1g
StickTopical154 mg/1mL
StickTopical11.4 g/100g
StickTopical14.8 g/100g
StickTopical12.9 g/100g
StickTopical0.204 g/1.36g
StickTopical14.6 g/73g
LiquidTopical16.3 mL/96.1mL
StickTopical15.4 g/73g
LiquidTopical16.3 g/96.1mL
GelTopical; Transmucosal16.4 g/100g
LiquidTopical16.3 g/16.3g
StickTopical13.94 g/85g
LiquidTopical16.3 g/96mL
LiquidTopical16.3 g/100mL
LiquidTopical16 g/96.1mL
GelTopical16.4 g/100g
StickTopical9.6 g/48g
StickTopical17 g/85g
StickTopical195.4 mg/1mL
StickTopical199 mg/1mL
StickTopical200 mg/1mL
StickTopical13.47 g/76.5g
GelTopical8.75 g/50g
GelTopical0.2 g/1g
StickTopical0.2 g/1g
GelTopical16 %
LotionTopical15 mL/100mL
CreamTopical20 g/100mL
LotionTopical14.39 g/100mL
StickTopical160 mg/100g
StickTopical200 mg/100g
GelTopical18 g/57g
LotionTopical15 g/100g
CreamTopical100 mg/1mL
LiquidTopical
LiquidTopical110 mg/1mL
CreamTopical99 mg/1mL
StickTopical200 mg/1g
StickCutaneous250 mg/1g
StickTopical151 mg/1g
StickTopical15.4 g/100g
StickTopical170 mg/1g
StickTopical154 mg/1g
StickTopical159 mg/1g
LiquidTopical0.20 g/1mL
StickTopical156 mg/1g
CreamTopical80 mg/1mL
CreamTopical17.8 g/100g
StickTopical0.15 g/1g
StickTopical15 g/100g
StickTopical18 g/100g
KitTopical18 g/100g
StickTopical0.16 g/1g
StickTopical17 g/100g
CreamTopical19 g/100g
StickTopical25 g/100g
StickTopical17.5 g/100g
StickTopical13.49 g/71g
StickTopical10.83 1/57g
StickTopical1.2 g/75g
LiquidTopical0.2 g/1mL
StickTopical14.062 g/79g
StickTopical2.0944 g/11.9g
StickTopical14 g/100g
StickTopical16.4 g/100g
StickTopical48 g/48g
StickTopical10.318 g/73.7g
StickTopical7.14 g/51g
GelTopical13.94 1/85g
StickTopical14.00 g/73g
GelTopical18.5 g/113g
StickTopical4.902 g/57g
StickTopical17.3 g/100g
KitDental; Topical
StickTopical22 g/100g
StickTopical12.8 g/64g
GelTopical15 g/100g
CreamTopical20 g/100g
StickTopical.028 g/1g
GelTopical0.16 g/1g
StickTopical13.87 g/73g
KitTopical
GelTopical17 g/100g
GelTopical16 g/100g
StickTopical0.19 g/1g
StickTopical0.192 g/1g
StickTopical0.18 g/1g
StickTopical10.83 g/57g
StickTopical19 g/57g
CreamTopical18.6 g/100g
StickTopical18.6 g/100mL
StickTopical13. g/73g
StickTopical13 g/65g
StickTopical85 g/85g
StickTopical164 mg/1g
StickTopical153 mg/1g
StickTopical161 mg/1g
StickTopical172 mg/1g
StickTopical158 mg/1g
StickTopical100 mg/1g
StickTopical160 mg/1g
StickTopical14.4 g/75g
StickTopical18.2 g/100g
StickTopical19 g/100g
StickTopical16 g/100g
StickTopical152 mg/1g
StickTopical0.17 g/1g
StickTopical18.4 g/100g
GelTopical19 g/100g
LiquidTopical21 g/100mL
SolutionTopical20 g/100g
StickCutaneous17.8 1/1
StickCutaneous16.0 1/1
StickTopical0.20 g/1g
CreamTopical0.20 g/1g
StickTopical180 mg/1g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility11.9 mg/mLALOGPS
logP0.36ALOGPS
logP-3.4Chemaxon
logS-1.2ALOGPS
pKa (Strongest Acidic)2.31Chemaxon
pKa (Strongest Basic)9.24Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area66.15 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity26.84 m3·mol-1Chemaxon
Polarizability6.25 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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1. Sweat ducts
Kind
Group
Organism
Humans
Pharmacological action
Yes
Actions
Antagonist
References
  1. LABEL: SECRET COOL WATERLILY CLEAR- aluminum zirconium octachlorohydrex gly gel [Link]
  2. Health Canada Document : Chemical Substance - Aluminum zirconium octachlorohydrex glycine [Link]
  3. Scientific Committee on Consumer Safety SCCS [File]

Drug created at December 03, 2015 16:51 / Updated at September 28, 2021 21:54