Panthenol

Identification

Summary

Panthenol is an ingredient used in skin, hair care, and nutritional products but is not an approved medication.

Generic Name
Panthenol
DrugBank Accession Number
DB11204
Background

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol). While pantothenic acid is optically active, only the dextrorotatory form (Dexpanthenol) is biologically active.

Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium 1.

Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 2.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 205.254
Monoisotopic: 205.131408096
Chemical Formula
C9H19NO4
Synonyms
  • DL-panthenol
  • DL-Pantothenol
  • Pantenol
  • Panthenol
  • Panthenolum

Pharmacology

Indication

Panthenol (containing a racemic mixture of dexpanthenol and levopanthenol) is not currently available in any FDA-approved products and therefore does not have an indication.

Please see Dexpanthenol for FDA-approved uses of the dextrorotatory form of Panthenol.

Pharmacology
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Associated Conditions
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Contraindications
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Pharmacodynamics

Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.

Mechanism of action

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium 1.

Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 2.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Hover over products below to view reaction partners

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
AAPE Hair AmpouleLiquid0.03 g/6mLTopicalProstemics Co., Ltd.2019-08-01Not applicableUS flag
AAPE Hair AmpouleLiquid0.5 g/100mLTopicalProstemics Co., Ltd.2021-05-01Not applicableUS flag
Ahc Hydra B5 SootherLiquid0.5 g/50mLTopicalCarver Korea Co.,Ltd.2017-05-122018-12-01US flag
Ahc Hydra B5 Soother (red)Liquid0.5 g/50mLTopicalCarver Korea Co.,Ltd.2017-05-122018-12-01US flag
Ahc Premium Hydra Soother Cellulose MaskPatch0.081 g/27mLTopicalCarver Korea Co.,Ltd.2017-05-182018-12-01US flag
BABOR Baborganic Calm and RelaxCream0.04875 g/50mLTopicalBabor Cosmetics America, Corp.2008-11-012017-02-12US flag
BABOR BODY LINE THERMAL Firming BodyLotion1.5 g/200mLTopicalBabor Cosmetics America, Corp.2006-04-152017-02-12US flag
Babor Body Line Thermal Smooth Effect BodyLotion1.8 mL/200mLTopicalBabor Cosmetics America, Corp.2010-04-102017-02-16US flag
BABOR CLEANSING Mild CleanserLiquid0.75 mL/200mLTopicalBabor Cosmetics America, Corp.2004-04-152017-02-15US flag
BABOR HSR Lifting Decollete MaskGel1.5 mL/100mLTopicalBabor Cosmetics America, Corp.2009-11-012017-02-16US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
24 Alopecia ReliefshampooPanthenol (0.2 g/100mL) + Levomenthol (0.3 g/100mL) + Salicylic acid (0.25 g/100mL)ShampooTopicalDERMA CENTRIC INC2020-08-08Not applicableUS flag
574H Cell CarePanthenol (1.5 g/300mL) + Biotin (0.18 g/300mL) + Nicotinamide (0.9 g/300mL) + Pyrithione zinc (3.0 g/300mL)ShampooTopicalCelino Inc.2020-06-01Not applicableUS flag
Add More HairPanthenol (0.5 g/100mL) + Pyrithione zinc (0.28 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2018-06-092018-09-05US flag
Add More HairPanthenol (0.5 g/100mL) + Pyrithione zinc (0.29 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2017-03-012018-09-04US flag
Adeks - DpsPanthenol (3 mg / mL) + Ascorbic acid (45 mg / mL) + Beta carotene (1 mg / mL) + Biotin (15 mcg / mL) + Cyanocobalamin (4 mcg / mL) + Nicotinamide (6 mg / mL) + Phylloquinone (0.1 mg / mL) + Pyridoxine hydrochloride (0.6 mg / mL) + Riboflavin (0.6 mg / mL) + Thiamine (0.5 mg / mL) + Vitamin A palmitate (1500 unit / mL) + Vitamin D (400 unit / mL) + Vitamin E (40 unit / mL) + Zinc (5 mg / mL)Solution / dropsOralAxcan Pharma1995-12-312007-10-01Canada flag
Ahc Radiance Gommage PeelingPanthenol (1 g/100mL) + Allantoin (1 g/100mL)GelTopicalCarver Korea Co.,Ltd.2017-05-102018-12-01US flag
All New TSPanthenol (0.5 g/100mL) + Nicotinamide (0.3 g/100mL)ShampooTopicalTalmocom Co., Ltd2016-07-012018-05-01US flag
Atomy Hair TreatmentPanthenol (0.40 mg/200mL) + Levomenthol (0.60 mg/200mL) + Salicylic acid (0.38 mg/200mL)LiquidTopicalAtomy Co., Ltd.2015-02-012017-12-01US flag
BABOR Baborganic Age Preventing Body CreamPanthenol (1.8 mg/200mL) + Glycerin (2 mg/200mL)CreamTopicalBabor Cosmetics America, Corp.2008-11-012017-02-12US flag
BANACOS Centellamide Cica PeptidecreamPanthenol (1.5 g/100mL) + Dimethicone (1 g/100mL) + Glycerin (0.1159 g/100mL)CreamTopicalCleoslab Co., Ltd2020-07-16Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
24 Alopecia ReliefshampooPanthenol (0.2 g/100mL) + Levomenthol (0.3 g/100mL) + Salicylic acid (0.25 g/100mL)ShampooTopicalDERMA CENTRIC INC2020-08-08Not applicableUS flag
574H Cell CarePanthenol (1.5 g/300mL) + Biotin (0.18 g/300mL) + Nicotinamide (0.9 g/300mL) + Pyrithione zinc (3.0 g/300mL)ShampooTopicalCelino Inc.2020-06-01Not applicableUS flag
AAPE Hair AmpoulePanthenol (0.03 g/6mL)LiquidTopicalProstemics Co., Ltd.2019-08-01Not applicableUS flag
AAPE Hair AmpoulePanthenol (0.5 g/100mL)LiquidTopicalProstemics Co., Ltd.2021-05-01Not applicableUS flag
Add More HairPanthenol (0.5 g/100mL) + Pyrithione zinc (0.28 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2018-06-092018-09-05US flag
Add More HairPanthenol (0.5 g/100mL) + Pyrithione zinc (0.29 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2017-03-012018-09-04US flag
Ahc Hydra B5 SootherPanthenol (0.5 g/50mL)LiquidTopicalCarver Korea Co.,Ltd.2017-05-122018-12-01US flag
Ahc Hydra B5 Soother (red)Panthenol (0.5 g/50mL)LiquidTopicalCarver Korea Co.,Ltd.2017-05-122018-12-01US flag
Ahc Premium Hydra Soother Cellulose MaskPanthenol (0.081 g/27mL)PatchTopicalCarver Korea Co.,Ltd.2017-05-182018-12-01US flag
Ahc Radiance Gommage PeelingPanthenol (1 g/100mL) + Allantoin (1 g/100mL)GelTopicalCarver Korea Co.,Ltd.2017-05-102018-12-01US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
WV9CM0O67Z
CAS number
16485-10-2
InChI Key
SNPLKNRPJHDVJA-UHFFFAOYSA-N
InChI
InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)
IUPAC Name
2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
SMILES
CC(C)(CO)C(O)C(=O)NCCCO

References

General References
  1. Proksch E, de Bony R, Trapp S, Boudon S: Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080/09546634.2017.1325310. Epub 2017 May 14. [Article]
  2. Biro K, Thaci D, Ochsendorf FR, Kaufmann R, Boehncke WH: Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 2003 Aug;49(2):80-4. [Article]
Human Metabolome Database
HMDB0004231
KEGG Drug
D03726
ChemSpider
4516
RxNav
1044977
ChEBI
27373
ChEMBL
CHEMBL1371937
Wikipedia
Panthenol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAllergic Disorder of Respiratory System / Cold / Flu caused by Influenza1
3CompletedTreatmentDiabetic Foot Ulcers (DFUs)1
3TerminatedTreatmentDiabetic Foot Ulcers (DFUs)1
Not AvailableNot Yet RecruitingTreatmentSolar Elastosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical0.03 g/6mL
Solution / dropsOral
LiquidTopical0.5 g/50mL
PatchTopical0.081 g/27mL
GelTopical
CreamTopical
CreamTopical0.04875 g/50mL
LotionTopical1.5 g/200mL
LotionTopical1.8 mL/200mL
LiquidTopical0.75 mL/200mL
GelTopical1.5 mL/100mL
CreamTopical0.4875 mL/50mL
CreamTopical1.5 mL/200mL
LiquidTopical0.075 mL/10mL
SprayTopical0.5 g/50mL
LiquidTopical0.45 g/30mL
LotionTopical0.09 g/12mL
ElixirTopical
LiquidTopical0.003 g/5mL
LotionTopical0.375 g/50mL
LiquidTopical0.375 1/50mL
Injection, solutionIntramuscular; Intravenous
LiquidTopical0.002 mg/1mL
ShampooTopical
LotionTopical
LiquidTransdermal
LiquidTopical
GelTopical0.01 mL/100mL
LiquidTopical0.018 mL/2mL
KitTopical
CreamTopical0.47 g/479.39g
LiquidTopical3.75 g/750mL
ShampooTopical0.02 mL/1mL
LiquidTopical0.002 mL/1mL
LiquidIntravenous
SprayTopical
SolutionIntravenous
SyrupOral
LiquidTopical0.50 g/50mL
Powder
PatchTopical
SolutionTopical
CreamTopical0.45 mL/50mL
CreamTopical1.8 mL/200mL
LiquidTopical0.3 g/30mL
LotionTopical15 mg/1mL
ShampooTopical1.2 mg/240mL
LiquidTopical0.5 mg/100mL
ShampooTopical0.002 mL/1mL
ShampooTopical0.95 g/958.50g
GelTopical0.95 g/958.50g
EmulsionTopical
LiquidTopical0.5 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility121.0 mg/mLALOGPS
logP-1ALOGPS
logP-1.7ChemAxon
logS-0.23ALOGPS
pKa (Strongest Acidic)12.69ChemAxon
pKa (Strongest Basic)-2.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area89.79 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity51.88 m3·mol-1ChemAxon
Polarizability22.15 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 16:51 / Updated on May 14, 2021 01:06