Ferrous bisglycinate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Irospan 24/6 Kit
Generic Name
Ferrous bisglycinate
DrugBank Accession Number
DB11210
Background

Ferrous bisglycinate is a chelate that is used as a source of dietary iron. Forming a ring structure when reacting with glycine, ferrous bisglycinate acts as both a chelate and a nutritionally functional 2. It is found in foods for food enrichment or in supplements for the treatment of iron deficiency or iron deficiency anemia.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 203.963
Monoisotopic: 203.983343
Chemical Formula
C4H8FeN2O4
Synonyms
Not Available

Pharmacology

Indication

Not Available

Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:
Machine Learning
Data Science
Drug Discovery
Accelerate your drug discovery research with our fully connected ADMET dataset
Learn more
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
With our commercial data, access important information on dangerous risks, contraindications, and adverse effects.
Learn more
Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
Reduce medical errors
and improve treatment outcomes with our comprehensive & structured data on drug adverse effects.
Learn more
Reduce medical errors & improve treatment outcomes with our adverse effects data
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Alendronic acidFerrous bisglycinate can cause a decrease in the absorption of Alendronic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
AlmasilateAlmasilate can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphateAluminium phosphate can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
AsenapineAsenapine can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium PhosphateFerrous bisglycinate can cause a decrease in the absorption of Calcium Phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium phosphate dihydrateFerrous bisglycinate can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
CarbidopaFerrous bisglycinate can cause a decrease in the absorption of Carbidopa resulting in a reduced serum concentration and potentially a decrease in efficacy.
CefdinirFerrous bisglycinate can cause a decrease in the absorption of Cefdinir resulting in a reduced serum concentration and potentially a decrease in efficacy.
CimetidineCimetidine can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Interactions
Improve patient outcomes
Build effective decision support tools with the industry’s most comprehensive drug-drug interaction checker.
Learn more
Food Interactions
No interactions found.

Products

Products
Comprehensive & structured drug product info
From application numbers to product codes, connect different identifiers through our commercial datasets.
Learn more
Easily connect various identifiers back to our datasets
Learn more
Product Ingredients
IngredientUNIICASInChI Key
Ferrous bisglycinate hydrochlorideIW3QLZ8MRC67972-33-2JTLXXRNVKWTJHD-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
IronunknownE1UOL152H77439-89-6XEEYBQQBJWHFJM-UHFFFAOYSA-N
Ferrous cationionicGW89581OWR15438-31-0CWYNVVGOOAEACU-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
TUGALFerrous bisglycinate (19 mg) + Ascorbic acid (42 mg) + Calcium carbonate (120 mg) + Cholecalciferol (440 IU) + Cobaltous sulfate heptahydrate (50 mcg) + Cupric sulfate (1 mg) + Cyanocobalamin (1.15 IU) + Doconexent (300 mg) + Folic acid (1 mg) + Icosapent (25 mg) + Magnesium sulfate (14 mg) + Manganese (1 mg) + Nicotinamide (8.189 mg) + Pantothenic acid (17.5 mg) + Potassium sulfate (8 mg) + Pyridoxine hydrochloride (1.05 mg) + Riboflavin (2.2 mg) + Sodium fluoride (90 mcg) + Sodium molybdate (51 mcg) + Thiamine mononitrate (2.5 mg) + Vitamin A palmitate (5610 IU) + Vitamin E (10.5 IU) + Zinc oxide (0.2 mg)Capsule, liquid filledOralPROCAPS S.A.2017-09-28Not applicableColombia flag
VINATAL DHA CAPSULA DE GELATINA BLANDAFerrous bisglycinate (19 mg) + Ascorbic acid (42 mg) + Calcium carbonate (120 mg) + Cholecalciferol (440 IU) + Cobaltous sulfate heptahydrate (50 mcg) + Cupric sulfate pentahydrate (1 mg) + Cyanocobalamin (1.15 mcg) + Doconexent (300 mg) + Fish oil (25 mg) + Folic acid (1 mg) + Magnesium sulfate (14 mg) + Manganese (1 mg) + Nicotinamide (8.189 mg) + Calcium pantothenate (17.5 mg) + Potassium sulfate (8 mg) + Pyridoxine hydrochloride (1.05 mg) + Riboflavin (2.2 mg) + Sodium fluoride (90 mcg) + Sodium molybdate dihydrate (51 mcg) + Thiamine mononitrate (2.5 mg) + Vitamin A palmitate (5610 IU) + Vitamin E (10.5 IU) + Zinc oxide (0.2 mg)Capsule, liquid filledOralPROCAPS S.A.2018-05-24Not applicableColombia flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
FeRivaFerrous bisglycinate (75 mg/1) + Ascorbic acid (175 mg/1) + Biotin (300 ug/1) + Cyanocobalamin (120 ug/1) + Folic acid (1 mg/1)CapsuleOralAvion Pharmaceuticals, Llc2012-11-262014-11-30US flag
FeRiva FAFerrous bisglycinate (36.7 mg/1) + Ascorbic acid (175 mg/1) + Biotin (300 ug/1) + Cupric oxide (1.5 mg/1) + Cyanocobalamin (12 ug/1) + Docusate sodium (50 mg/1) + Ferrous asparto glycinate (36.7 mg/1) + Ferrous fumarate (36.7 mg/1) + Folic acid (1 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2015-01-01Not applicableUS flag
FeRivaFAFerrous bisglycinate (110 mg/1) + Ascorbic acid (175 mg/1) + Biotin (300 ug/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (12 ug/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-01-022015-12-31US flag
Folet DHAFerrous bisglycinate (38 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2700 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (18 [iU]/1) + Doconexent (350 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (40 mg/1) + Riboflavin (3.4 mg/1) + Selenium (65 ug/1) + Thiamine hydrochloride (3 mg/1) + Zinc glycinate (10 mg/1)OralPronova Corporation2014-08-282017-03-15US flag
healthy mamaBE WELL ROUNDED BE WELL ROUNDEDFerrous bisglycinate (28 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (4000 [iU]/1) + Biotin (30 ug/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Folic acid (800 ug/1) + Magnesium oxide (30 mg/1) + Mecobalamin (8 ug/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2.6 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.8 mg/1) + Zinc oxide (25 mg/1)Tablet, film coatedOralMATERNAL SCIENCE, LLC2013-07-09Not applicableUS flag
Irospan 24/6Ferrous bisglycinate (65 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)OralWOMENS CHOICE PHARMACEUTICALS LLC2011-04-15Not applicableUS flag
NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPAFerrous bisglycinate (32 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + Doconexent (230 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Tocopherylquinone (30 [iU]/1) + Vitamin E (2 [iU]/1) + Zinc oxide (10 mg/1)KitOralWOMENS CHOICE PHARMACEUTICALS LLC2011-02-01Not applicableUS flag
NESTABS Prenatal Multi-vitamin/Mineral SupplementFerrous bisglycinate (32 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)Tablet, film coatedOralWOMENS CHOICE PHARMACEUTICALS LLC2011-02-01Not applicableUS flag
Nutri-Tab OBFerrous bisglycinate (32 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Folic acid (1000 ug/1) + Calcium formate (155 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)TabletOralWh Nutritionals, Llc2012-05-032014-10-31US flag
Nutri-Tab OB plus DHAFerrous bisglycinate (32 mg/1) + Calcium carbonate (45 mg/1) + Cholecalciferol (450 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (10 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (230 mg/1) + Folic acid (1000 ug/1) + Calcium formate (155 mg/1) + Icosapent (30 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (100 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Sodium ascorbate (120 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (10 mg/1)TabletOralWh Nutritionals, Llc2012-05-032014-10-31US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acids
Alternative Parents
Carboxylic acid salts / Amino acids / Organic transition metal salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Aliphatic acyclic compound / Alpha-amino acid / Amine / Amino acid / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic nitrogen compound
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
SFW1D987QV
CAS number
20150-34-9
InChI Key
GIPOFCXYHMWROH-UHFFFAOYSA-L
InChI
InChI=1S/2C2H5NO2.Fe/c2*3-1-2(4)5;/h2*1,3H2,(H,4,5);/q;;+2/p-2
IUPAC Name
lambda2-iron(2+) ion bis(2-aminoacetate)
SMILES
[Fe++].NCC([O-])=O.NCC([O-])=O

References

General References
  1. Milman N, Jonsson L, Dyre P, Pedersen PL, Larsen LG: Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial. J Perinat Med. 2014 Mar;42(2):197-206. doi: 10.1515/jpm-2013-0153. [Article]
  2. Ashmead SD: The chemistry of ferrous bis-glycinate chelate. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):7-12. [Article]
PubChem Compound
9837124
PubChem Substance
347827942
ChemSpider
8012845
RxNav
1102188

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAnemia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
Capsule, gelatin coatedOral
Tablet, film coatedOral
KitOral
TabletOral
Tablet, coatedOral
Capsule, liquid filledOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility211.0 mg/mLALOGPS
logP-1.5ALOGPS
logP-3.4ChemAxon
logS0.02ALOGPS
pKa (Strongest Acidic)2.31ChemAxon
pKa (Strongest Basic)9.24ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area66.15 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity26.84 m3·mol-1ChemAxon
Polarizability6.25 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 16:51 / Updated on July 01, 2020 02:41