Trypsin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Trypsin
Accession Number
DB11237
Description

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate 1. This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.

Type
Small Molecule
Groups
Approved, Vet approved
Synonyms
  • Tripsina

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
GranulexTrypsin (0.12 mg/1g) + Balsam of Peru (87 mg/1g) + Castor oil (788 mg/1g)SprayTopicalMylan Institutional1967-03-012018-05-31US flag
OptaseTrypsin (0.012 g/100g) + Balsam of Peru (8.69 g/100g) + Castor oil (78.77 g/100g)GelTopicalOnset Dermatologics, LLC2006-04-012011-12-31US flag
Trypsin ComplexTrypsin (0.0036 mg/1g) + Balsam of Peru (87.0 mg/1g) + Castor oil (788.0 mg/1g)OintmentTopicalBreckenridge Pharmaceutical, Inc.2009-10-212011-06-30US flag
VasolexTrypsin (90 [USP'U]/1g) + Balsam of Peru (87 mg/1g) + Castor oil (788 mg/1g)OintmentTopicalStratus Pharmacuticals2007-02-072015-04-09US flag
XenadermTrypsin (90 [USP'U]/1g) + Balsam of Peru (87.0 mg/1g) + Castor oil (788.0 mg/1g)OintmentTopicalHealthpoint2002-03-012015-03-02US flag

Categories

ATC Codes
B06AA07 — TrypsinD03BA01 — TrypsinM09AB52 — Trypsin, combinations
Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
GV54A213NN
CAS number
9002-07-7
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Di Cera E: Serine proteases. IUBMB Life. 2009 May;61(5):510-5. doi: 10.1002/iub.186. [PubMed:19180666]
PubChem Substance
347911160
RxNav
10890
Wikipedia
Trypsin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingTreatmentSepsis / Shock, Septic1
4SuspendedTreatmentPancreatitis1
4Unknown StatusTreatmentCongenital Heart Disease (CHD)1
2CompletedTreatmentWounds1
2TerminatedTreatmentPressure Ulcers / Spinal Cord Injuries (SCI)1
2Unknown StatusTreatmentAcute Respiratory Distress Syndrome (ARDS)1
2WithdrawnTreatmentPartial Thickness Wounds1
1CompletedNot AvailableHealthy Volunteers2
Not AvailableUnknown StatusNot AvailableAdverse Reaction to Drug1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SprayTopical
GelTopical
OintmentTopical
Tablet, delayed releaseOral270 FIP units
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 09:51 / Updated on June 12, 2020 10:53

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