This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Trypsin is a naturally occurring proteolytic enzyme found in the digestive tract of mammals. Used clinically in combination with bromelain and rutosides in the treatment of some inflammatory conditions.

Generic Name
Trypsin
DrugBank Accession Number
DB11237
Background

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate 1. This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.

Type
Small Molecule
Groups
Approved, Vet approved
Synonyms
  • Tripsina
  • Trypsin

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetylcysteineThe therapeutic efficacy of Acetylcysteine can be decreased when used in combination with Trypsin.
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Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
KIMOSETrypsin (1 mg) + Bromelains (50 mg)Tablet, sugar coatedOralบริษัท นิวไลฟ์ฟาร์ม่า จำกัด จำกัด1998-01-272019-10-21Thailand flag
Traumazym - FilmtablettenTrypsin (1440 FIP units) + Bromelains (450 FIP units) + Rutoside trihydrate (100 mg)Tablet, film coatedOralMucos Pharma Gmb H & Co.Kg2001-08-02Not applicableAustria flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
GranulexTrypsin (0.12 mg/1g) + Balsam of Peru (87 mg/1g) + Castor oil (788 mg/1g)SprayTopicalMylan Institutional1967-03-012018-05-31US flag
OptaseTrypsin (0.012 g/100g) + Balsam of Peru (8.69 g/100g) + Castor oil (78.77 g/100g)GelTopicalOnset Dermatologics, LLC2006-04-012011-12-31US flag
Trypsin ComplexTrypsin (0.0036 mg/1g) + Balsam of Peru (87.0 mg/1g) + Castor oil (788.0 mg/1g)OintmentTopicalBreckenridge Pharmaceutical, Inc.2009-10-212011-06-30US flag
VasolexTrypsin (90 [USP'U]/1g) + Balsam of Peru (87 mg/1g) + Castor oil (788 mg/1g)OintmentTopicalStratus Pharmacuticals2007-02-072015-04-09US flag
XenadermTrypsin (90 [USP'U]/1g) + Balsam of Peru (87.0 mg/1g) + Castor oil (788.0 mg/1g)OintmentTopicalHealthpoint2002-03-012015-03-02US flag

Categories

ATC Codes
B06AA07 — TrypsinD03BA01 — TrypsinM09AB52 — Trypsin, combinations
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
GV54A213NN
CAS number
9002-07-7
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Di Cera E: Serine proteases. IUBMB Life. 2009 May;61(5):510-5. doi: 10.1002/iub.186. [Article]
  2. BASG Product Information: Phlogenzym (bromelain/trypsin/rutoside) film-coated tablets for oral use [Link]
PubChem Substance
347911160
RxNav
10890
Wikipedia
Trypsin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingTreatmentSepsis / Septic Shock1
4SuspendedTreatmentPancreatitis1
4Unknown StatusTreatmentCongenital Heart Disease (CHD)1
2CompletedTreatmentWound site1
2TerminatedTreatmentPressure Ulcers / Spinal Cord Injuries (SCI)1
2Unknown StatusTreatmentRespiratory Distress Syndrome, Acute (ARDS)1
2WithdrawnTreatmentPartial Thickness Wounds1
1CompletedNot AvailableHealthy Subjects (HS)2
Not AvailableUnknown StatusNot AvailableAdverse Reaction to Drug1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SprayTopical
Tablet, sugar coatedOral
GelTopical
Tablet, film coatedOral
OintmentTopical
Tablet, delayed releaseOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 03, 2015 16:51 / Updated at April 30, 2021 13:08