This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Borage oil
DrugBank Accession Number
DB11238
Background

Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurodermatitis as well as other inflammatory, cardiovascular and endocrine disorders, although its clinical efficacy and long-term effects are not fully elucidated yet. GLA, which accounts for approximately 24% of the oil, is converted to dihomo-γ-linolenic acid (DGLA) which acts as a precursor to anti-inflammatory mediators such as 1-series prostaglandins and the 3-series leukotrienes. Borage oil may be found in foods or in skin care products.

Type
Biotech
Groups
Approved, Investigational
Synonyms
  • Borago officinalis

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe therapeutic efficacy of Acetazolamide can be decreased when used in combination with Borage oil.
AmifampridineThe risk or severity of seizure can be increased when Borage oil is combined with Amifampridine.
AmobarbitalThe therapeutic efficacy of Amobarbital can be decreased when used in combination with Borage oil.
BrexanoloneThe therapeutic efficacy of Brexanolone can be decreased when used in combination with Borage oil.
BrivaracetamThe therapeutic efficacy of Brivaracetam can be decreased when used in combination with Borage oil.
BupropionThe risk or severity of seizure can be increased when Bupropion is combined with Borage oil.
ButalbitalThe therapeutic efficacy of Butalbital can be decreased when used in combination with Borage oil.
CannabidiolThe therapeutic efficacy of Cannabidiol can be decreased when used in combination with Borage oil.
CarbamazepineThe therapeutic efficacy of Carbamazepine can be decreased when used in combination with Borage oil.
CenobamateThe therapeutic efficacy of Cenobamate can be decreased when used in combination with Borage oil.
Interactions
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Food Interactions
No interactions found.

Products

Products2
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Borage Oil CapsulesBorage oil (500 mg) + Gamolenic acid (125 mg) + Linoleic acid (220 mg)CapsuleOralBioforce Canada Inc.1994-12-311999-10-14Canada flag
Cheon Shim Bo HwaBorage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1)CapsuleOralSaimdang Cosmetics Co., Ltd2011-04-06Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cheon Shim Bo HwaBorage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1)CapsuleOralSaimdang Cosmetics Co., Ltd2011-04-06Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
F8XAG1755S
CAS number
Not Available

References

General References
  1. Tocher DR, Bell JG, Farndale BM, Sargent JR: Effects of dietary gamma-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in delta5 fatty acyl desaturase. Prostaglandins Leukot Essent Fatty Acids. 1997 Aug;57(2):125-34. [Article]
  2. Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D: Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8. [Article]
  3. Chung S, Kong S, Seong K, Cho Y: Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J Nutr. 2002 Oct;132(10):3090-7. [Article]
  4. Foster RH, Hardy G, Alany RG: Borage oil in the treatment of atopic dermatitis. Nutrition. 2010 Jul-Aug;26(7-8):708-18. doi: 10.1016/j.nut.2009.10.014. [Article]
PubChem Substance
347911161
RxNav
68905
Wikipedia
Borage_seed_oil

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedBasic ScienceDiabetes / Syndrome, Metabolic1
1, 2CompletedTreatmentAsthma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
EmulsionOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at December 03, 2015 16:51 / Updated at April 01, 2021 12:32