Borage oil

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Borage oil
Accession Number
DB11238
Description

Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurodermatitis as well as other inflammatory, cardiovascular and endocrine disorders, although its clinical efficacy and long-term effects are not fully elucidated yet. GLA, which accounts for approximately 24% of the oil, is converted to dihomo-γ-linolenic acid (DGLA) which acts as a precursor to anti-inflammatory mediators such as 1-series prostaglandins and the 3-series leukotrienes. Borage oil may be found in foods or in skin care products.

Type
Small Molecule
Groups
Approved, Investigational
Synonyms
  • Borago officinalis

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe therapeutic efficacy of Acetazolamide can be decreased when used in combination with Borage oil.
AmifampridineThe risk or severity of seizure can be increased when Borage oil is combined with Amifampridine.
AmobarbitalThe therapeutic efficacy of Amobarbital can be decreased when used in combination with Borage oil.
BrexanoloneThe therapeutic efficacy of Brexanolone can be decreased when used in combination with Borage oil.
BrivaracetamThe therapeutic efficacy of Brivaracetam can be decreased when used in combination with Borage oil.
BupropionThe risk or severity of seizure can be increased when Bupropion is combined with Borage oil.
ButalbitalThe therapeutic efficacy of Butalbital can be decreased when used in combination with Borage oil.
CannabidiolThe therapeutic efficacy of Cannabidiol can be decreased when used in combination with Borage oil.
CarbamazepineThe therapeutic efficacy of Carbamazepine can be decreased when used in combination with Borage oil.
CenobamateThe therapeutic efficacy of Cenobamate can be decreased when used in combination with Borage oil.
Additional Data Available
  • Extended Description
    Extended Description
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  • Severity
    Severity
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  • Evidence Level
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  • Action
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Food Interactions
No interactions found.

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Borage Oil CapsulesBorage oil (500 mg) + Gamolenic acid (125 mg) + Linoleic acid (220 mg)CapsuleOralBioforce Canada Inc.1994-12-311999-10-14Canada flag
Cheon Shim Bo HwaBorage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1)CapsuleOralSaimdang Cosmetics Co., Ltd2011-04-06Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cheon Shim Bo HwaBorage oil (311 mg/1) + D-alpha-Tocopherol acetate (1 mg/1)CapsuleOralSaimdang Cosmetics Co., Ltd2011-04-06Not applicableUS flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
F8XAG1755S
CAS number
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Tocher DR, Bell JG, Farndale BM, Sargent JR: Effects of dietary gamma-linolenic acid-rich borage oil combined with marine fish oils on tissue phospholipid fatty acid composition and production of prostaglandins E and F of the 1-, 2- and 3-series in a marine fish deficient in delta5 fatty acyl desaturase. Prostaglandins Leukot Essent Fatty Acids. 1997 Aug;57(2):125-34. [PubMed:9250695]
  2. Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D: Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8. [PubMed:10233322]
  3. Chung S, Kong S, Seong K, Cho Y: Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. J Nutr. 2002 Oct;132(10):3090-7. [PubMed:12368400]
  4. Foster RH, Hardy G, Alany RG: Borage oil in the treatment of atopic dermatitis. Nutrition. 2010 Jul-Aug;26(7-8):708-18. doi: 10.1016/j.nut.2009.10.014. [PubMed:20579590]
PubChem Substance
347911161
RxNav
68905
Wikipedia
Borage_oil

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedBasic ScienceDiabetes / Metabolic Syndromes1
1, 2CompletedTreatmentAsthma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral300 mg
CapsuleOral
EmulsionOral4.4 g/15ml
CapsuleOral166 mg
CapsuleOral520 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 09:51 / Updated on June 12, 2020 10:53

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